Placental site trophoblastic tumor (trophoblastic pseudotumor) of the uterus with metastases and fatal outcome

Gloor, E; Dialdas, J; Hürlimann, J.; Ribolzi, J; Barrelet, L

doi:10.1097/00000478-198307000-00011

Cited by 54 publications

(23 citation statements)

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“…In a recent review of cases, Lathrop et al reported a 20% fatality rate in patients with PSTT ~2). At least 17 cases of metastatic PSTT have been previously reported, with a high fatality rate (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Chemotherapy has had limited success in metastatic PSTT, although one complete and some partial re-Address for correspondence: Laurel A.…”

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confidence: 99%

Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor

King

Okagaki

Twiggs

1992

Int J Gynecol Cancer

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Placental site trophoblastic tumor (PSTT), a rare variant of gestational trophoblastic disease, was first described in 1976. PSTT is usually seen in young women, generally treated by hysterectomy, and is associated with a 20% fatality rate. The development of metastases secondary to PSTT is associated with an extremely poor prognosis. Metastatic PSTT has generally been resistant to chemotherapy although one complete and some partial responses have been noted previously. We report a case of a complete chemotherapeutic response in a patient with pulmonary metastases.

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confidence: 99%

Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor

King

Okagaki

Twiggs

1992

Int J Gynecol Cancer

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“…Because of extensive infiltration of the myometrium present in many of the cases, there is significant risk of perforation of the uterus following D&C. 1 In three of the reported cases, patients have presented with edema of the lower extremitiesand proteinuria. 11,13 Renal biopsies in these cases revealed a distinctive glomerular lesion characterized by the presence of occlusive eosinophilic deposits within the capillary lumina. These deposits are composed of IgM-and fibrin-related products.…”

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confidence: 88%

Placental Site Trophoblastic Tumor: Report of a Case with Review of Literature

et al. 1987

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“…PSTT has been diagnosed after term pregnancies, spontaneous abortions, or a prior hydatidiform mole [4,7,8,24].…”

Section: Discussionmentioning

confidence: 99%

“…The histologic appearence echoes the infiltration of the endometrium and myometrium of the placental site [13]. The clinical behaviour of PSTT is usually benign, but can be highly malignant [7]. And there are no reliable histologic, immunohistochemical, or DNA ploidy predictors of clinical outcome [5,11,13].…”

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confidence: 99%

Metastasizing placental site trophoblastic tumor: immunohistochemical and DNA analysis. 2 case reports and a review of the literature

Remadi

Lifschitz-Mercer

Ben-Hur

et al. 1997

Archives of Gynecology and Obstetrics

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Abstract. Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.

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Placental site trophoblastic tumor (trophoblastic pseudotumor) of the uterus with metastases and fatal outcome

Cited by 54 publications

References 0 publications

Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor

Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor

Placental Site Trophoblastic Tumor: Report of a Case with Review of Literature

Metastasizing placental site trophoblastic tumor: immunohistochemical and DNA analysis. 2 case reports and a review of the literature

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