Placental site trophoblastic tumor in a postmenopausal female—A case report

Nigam, Sonu; Singhal, Niti; Gupta, Sanjeev Kumar; Chhabra, Divye; Manaktala, Usha

doi:10.1016/j.ygyno.2004.01.045

Cited by 15 publications

(15 citation statements)

References 8 publications

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“…In contrast to moles occurring during the reproductive years, postmenopausal GTNs seems independent from gestation [1,3]. The development of GTN 30 years after menopause despite a history of pelvic radiotherapy in the previously reported case also supports this idea.…”

supporting

confidence: 71%

“…The development of GTN 30 years after menopause despite a history of pelvic radiotherapy in the previously reported case also supports this idea. The theory of GTNs dormant for long periods was proposed to explain their pathogenesis in postmenopausal women [1,3], but pathogenesis actually remains obscure. On the basis of the short postmenopausal period and presence of corpus luteum in the present case, the authors speculate that spontaneous ovulation followed by a defective fertilization might be another explanation for invasive mole development in postmenopausal women.…”

mentioning

confidence: 99%

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Invasive mole in a postmenopausal woman

Taşkın

Cengiz

Ortaç

2006

International Journal of Gynecology & Obstetrics

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supporting

confidence: 71%

mentioning

confidence: 99%

Invasive mole in a postmenopausal woman

Taşkın

Cengiz

Ortaç

2006

International Journal of Gynecology & Obstetrics

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“…In der Postmcnopausc dagegen treten diese Tumoren äusserst selten auf |4-7|. Die älteste in der Literatur mitgeteilte Patientin war 63-jäh-rig und seit 12 Jahren in der Postmenopause [7]. Betroffen von PSTT sind Patientinnen mit einer oder mehreren, durchschnittlich 2.2 vorangegangenen Schwangerschaften [3], meist mit Termingehurt (53-71%) [2,3>6j.…”

Section: Fallberichtunclassified

“…Dies legt die Vermutung nahe, dass der PSTT bei der letzten Schwangerschaft entstanden ist und es )ahre dauern kann bis zu dessen klinischen Manifestation [7].…”

Section: Fallberichtunclassified

Placental site trophoblastic tumor - Ein Fallbericht und Literaturübersicht

Kunz

Bannwart²

2008

Praxis

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A 32-year-old para 3 patient is presented having suffered from a silent uterine rupture on the occasion of her second and third Caesarean sections. After the third Caesarean section, there was light uterine bleeding whilst the patient breastfed for five months. Amenorrhoea then ensued due to oral contraception. Regular clinical and ultrasound checks revealed negative serum beta-HCG values and retrovesicular resistance, which increased in size after 18 months and became symptomatic. Because the patient's family was complete, abdominal hysterectomy without adnexectomy was performed. Histology revealed a placental site trophoblastic tumour (PSTT). This is a rare tumour with malignant potential, whose prognosis depends on the stage of the primary tumour, the period of time between the last pregnancy and onset of disease, the patient's age, and the rate of mitosis, and whose progress cannot be assessed using the WHO Prognostic Index Score for Gestational Trophoblastic Disease. In therapeutic terms, hysterectomy is recommended. Chemosensitivity is low and, due to the infrequency of the tumours, the most suitable chemotherapy scheme is unknown. In the case of metastasising or recurrent PSTT, the EP/EMA regime has proved to be most effective.

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“…These patients have persistent low levels of serum hCG (100-1000 mIU/mL). However, serum hCG levels as high as 108,000 mIU/mL have been reported in patients with PSTT [24]. The most frequent sites of metastases of malignant gestational trophoblastic neoplasia are the lungs, lower genital tract, brain, liver, kidney, and gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%