Placental protein expression of kisspeptin-1 (KISS1) and the kisspeptin-1 receptor (KISS1R) in pregnancy complicated by diabetes mellitus or preeclampsia

Kapustin, Roman V.; Дробинцева, А О; Alekseenkova, Elena N.; Onopriychuk, A R; Arzhanova, Olga N.; Polyakova, V. I.; Kvetnoy, Igor M.

doi:10.1007/s00404-019-05408-1

Cited by 28 publications

(29 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…al (ADAM12,GULP1,SERPINB2,CYP19A1,MUC15,SVEP1,GPC3,FBN2,DEPDC1B,ATG9B,EFHD1,KISS1,FAM13A,PKIB,S100A9,SCIN,OLAH,CCK), suggesting that the expression of these genes is highly divergent not only between human and rhesus but also between human and other species. Two of these genes, ADAM12 and KISS1, are associated with pre-eclampsia (Enquobahrie et al 2012;Kapustin et al 2020) supporting our finding that pre-eclampsia related genes are significantly over-represented in the human-upregulated placental gene set.…”

Section: Discussionsupporting

confidence: 86%

“…1F, Supplemental Table S5). Notably, placental markers associated with invasive EVTs (ADAM12, LGALS13, PAPPA2, PGF) (Hutter et al 2016;Knuth et al 2015;Athanassiades and Lala 1998), and pregnancy complications such as preterm birth and pre-eclampsia (ADAM12, HSD17B1, KISS1, LGALS13, PAPPA2, SIGLEC6, ERVW-1) (Enquobahrie et al 2012;Ishibashi et al 2012;Kapustin et al 2020;Sekizawa et al 2009;Nishizawa et al 2008;Kaartokallio et al 2015;Knerr et al 2002), were found to be upregulated in human compared to rhesus placental tissue (Fig. 1G).…”

Section: Comparison Of Placental Marker Expression Between Human and mentioning

confidence: 98%

See 1 more Smart Citation

Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation

Rosenkrantz

Gaffney

Roberts

et al. 2020

Preprint

View full text Add to dashboard Cite

Proper placentation, including trophoblast differentiation and function, is essential for the health and well-being of both the mother and baby throughout pregnancy. Placental abnormalities that occur during the early stages of development are thought to contribute to pre-eclampsia and other placenta-related pregnancy complications. However, relatively little is known about these stages in humans due to obvious ethical and technical limitations. Rhesus macaques are considered an ideal surrogate for studying human placentation, but the unclear translatability of known human placental markers and lack of accessible rhesus trophoblast cell lines can impede the use of this animal model. Here, we performed a cross-species transcriptomic comparison of human and rhesus placenta and determined that while the majority of known placental markers were similarly expressed, 952 differentially expressed genes (DEGs) were identified between the two species. Pathway enrichment analysis of the 447 human-upregulated DEGs, including ADAM12, ERVW-1, KISS1, LGALS13, PAPPA2, PGF, and SIGLEC6, revealed over-representation of functional terms associated with pre-eclampsia and other pregnancy disorders. Additionally, to enable in vitro functional studies of early placentation, we generated and thoroughly characterized two highly-pure first-trimester telomerase (TERT) immortalized rhesus trophoblast cell lines (iRP-D26 and iRP-D28A) that retained crucial features of isolated primary trophoblasts. Overall, our findings help elucidate the molecular translatability between human and rhesus placenta and reveal notable expression differences in human placental markers and genes associated with pregnancy complications that should be considered when using the rhesus animal model to study normal and pathological human placentation.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Comparison Of Placental Marker Expression Between Human and mentioning

confidence: 98%

Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation

Rosenkrantz

Gaffney

Roberts

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, hyperglycemia in pregnancy is known to be associated with adverse long-term health outcomes both for mother and offspring with 2–5 fold increased risk of congenital anomaly, stillbirth and neonatal death compared with the general maternity population [ 187 ]. Studies of impact of genetic variability in drug efficacy and adverse effects in pregnant women with T2D also would be of great interest.…”

Section: Discussionmentioning

confidence: 99%

Pharmacogenetics of Type 2 Diabetes—Progress and Prospects

Nasykhova

Tonyan

Михайлова

et al. 2020

IJMS

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion, which leads to impaired glucose utilization, dyslipidemia and hyperinsulinemia and progressive pancreatic beta cell dysfunction. The incidence of type 2 diabetes mellitus is increasing worldwide and nowadays T2D already became a global epidemic. The well-known interindividual variability of T2D drug actions such as biguanides, sulfonylureas/meglitinides, DPP-4 inhibitors/GLP1R agonists and SGLT-2 inhibitors may be caused, among other things, by genetic factors. Pharmacogenetic findings may aid in identifying new drug targets and obtaining in-depth knowledge of the causes of disease and its physiological processes, thereby, providing an opportunity to elaborate an algorithm for tailor or precision treatment. The aim of this article is to summarize recent progress and discoveries for T2D pharmacogenetics and to discuss the factors which limit the furthering accumulation of genetic variability knowledge in patient response to therapy that will allow improvement the personalized treatment of T2D.

show abstract

“…и соавт. исследовали экспрессию KISS1 и KISS1R при нормальной беременности, беременности при СД1, СД2, ГСД и беременности, осложненной ПЭ [58]. Самые высокие показатели экспрессии KISS1 были обнаружены в группах ПЭ (35,4%) и ГСД (33,2%).…”

Section: влияние сахарного диабета на формирование фетоплацентарного комплексаunclassified

Comparative morphofunctional analysis of the state of fetoplacental complex in diabetes mellitus (literature review)

Grigoryan

Absatarova

Михеев

et al. 2020

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

This article reviews the literature on placental morphofunctional changes in placenta of patients with type 1 and type 2 diabetes mellitus and gestational diabetes mellitus. The detailed analysis of features of pathogenesis of various abnormalities of the fetoplacental complex depending on the type of diabetes, its influence on the formation of the placental vascular bed. The analysis of mechanisms of development of placenta formation disorders, pathologies of placental vascular bed, the role of hyperglycemia and hyperinsulinemia in villous maturation, placental weight gain, perinatal outcomes. The discussed anomalies have a significant impact on the fetoplacental complex, acting as epigenetic factors, forming the environment for the fetus, which may later affect the health of the unborn child. They lead to adverse perinatal outcomes, including high infant morbidity and mortality. Literature search was performed in Russian (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English languages. The free access to the full text of the articles was in priority. The selection of sources was prioritized for the period from 2016 to 2020. However, due to the lack of knowledge of the chosen topic, the selection of sources was dated from 2001.

show abstract

Placental protein expression of kisspeptin-1 (KISS1) and the kisspeptin-1 receptor (KISS1R) in pregnancy complicated by diabetes mellitus or preeclampsia

Cited by 28 publications

References 27 publications

Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation

Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation

Pharmacogenetics of Type 2 Diabetes—Progress and Prospects

Comparative morphofunctional analysis of the state of fetoplacental complex in diabetes mellitus (literature review)

Contact Info

Product

Resources

About