Placental propofol transfer and fetal sedation during maternal general anaesthesia in early pregnancy

Jauniaux, Eric; Gulbis, Béatrice; Shannon, Claire; Maes, Veronique; Bromley, Lesley; Rodeck, Charles

doi:10.1016/s0140-6736(05)60265-6

Cited by 41 publications

(12 citation statements)

References 2 publications

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“…Methohexital sodium and propofol, the two most common anesthetic agents used for ECT [75], are drugs with short-acting effects, but they can cross the placental barrier [76,77]. Furthermore, blood levels of these drugs in the fetus and newborn are associated with maternal serum levels [78,79].…”

Section: Discussionmentioning

confidence: 99%

Electroconvulsive treatment during pregnancy: a systematic review

Pompili

Dominici

Giordano

et al. 2014

Expert Review of Neurotherapeutics

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Pharmacological treatment of severe psychiatric disorders during pregnancy is complicated by the potential harmful effects of treatment for the fetus. Electroconvulsive therapy (ECT) has been demonstrated to be effective for the treatment of several mental disorders. The aim of this study was to investigate the safety of ECT in the treatment of psychiatric disorders during pregnancy; to compare its efficacy with medication; and to identify the main indications for use in pregnancy. We performed a careful and systematic review of the literature on ECT and pregnancy was conducted. Almost all patients demonstrated total or at least partial remission of symptoms after ECT treatment. No deaths were reported in ECT-treated pregnant women. We conclude that ECT is probably currently under-used in many psychiatric settings because of its stigmatized perception by patients and by mental health professionals. ECT seems to be effective for treating major psychiatric disorders during pregnancy, and the risks of adverse events are low.

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Section: Discussionmentioning

confidence: 99%

Electroconvulsive treatment during pregnancy: a systematic review

Pompili

Dominici

Giordano

et al. 2014

Expert Review of Neurotherapeutics

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show abstract

“…We recommend use of propofol in the lowest effective dose, which is classified category B by Food and Drug Administration (FDA). It rapidly passes placental barrier, foetal blood levels reach about 70% of maternal blood levels . Human studies found no differences regarding APGAR‐Score and post‐partal neurological status for the use of propofol (at doses of 2–2.8 mg/kg) compared to thiopental in Caesarean section .…”

Section: Pregnancymentioning

confidence: 97%

Review article: the management of Crohn's disease and ulcerative colitis during pregnancy and lactation

Schulze

Esters

Dignaß

2014

Aliment Pharmacol Ther

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“…Both propofol and methohexital are shortacting general anesthetics that readily cross the placental barrier (79,80) and their levels in the fetus and newborn vary with maternal serum levels (81,82). The pharmacodynamic properties of propofol and methohexital are relatively constant throughout pregnancy and neither drug is associated with teratogenicity.…”

Section: Anesthetic Agentsmentioning

confidence: 99%

ECT in Pregnancy: A Review of the Literature From 1941 to 2007

Anderson

Reti

2009

Psychosomatic Medicine

168

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Objective: To review the literature on the use of electroconvulsive therapy (ECT) during pregnancy and to discuss its risks and benefits for treating severe mental illness during pregnancy. Method: PubMed and PsycINFO databases were searched for English or English-translated articles, case reports, letters, chapters, and Web sites providing original contributions and/or summarizing prior data on ECT administration during pregnancy. Results: A total of 339 cases were found. The majority of patients were treated for depression and at least partial remission was reported in 78% of all cases where efficacy data were available. Among the 339 cases reviewed, there were 25 fetal or neonatal complications, but only 11 of these, which included two deaths, were likely related to ECT. There were 20 maternal complications reported and 18 were likely related to ECT. Conclusions: Although there are limited available data in the literature, it seems that ECT is an effective treatment for severe mental illness during pregnancy and that the risks to fetus and mother are low.

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Placental propofol transfer and fetal sedation during maternal general anaesthesia in early pregnancy

Cited by 41 publications

References 2 publications

Electroconvulsive treatment during pregnancy: a systematic review

Electroconvulsive treatment during pregnancy: a systematic review

Review article: the management of Crohn's disease and ulcerative colitis during pregnancy and lactation

ECT in Pregnancy: A Review of the Literature From 1941 to 2007

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