Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia

Nartita, Tatsuya; Ichihara, Atsuhiro; Matsuoka, Kikumi; Takai, Yasushi; Bokuda, Kanako; Morimoto, Satoshi; Itoh, Hiroshi

doi:10.1016/j.placenta.2015.11.007

Cited by 46 publications

(32 citation statements)

References 23 publications

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“…As observed by Nartita et al (120), overactivation of the placental RAAS by placental ischemia leads to increased AngII-mediated pressor response and sympathetic nerve activity. If left untreated, the resulting hypertension can increase the risk of the loss of CBF autoregulation, increase in cerebral perfusion pressure, and eventual damage to the blood brain barrier (135, 136).…”

Section: The Autonomic Regulation Of Cardiovascular Physiological Adamentioning

confidence: 69%

“…Mistry et al, (119) observed that the placental RAAS exhibits the same degree of autonomy as the renal RAAS, but whose components are derived from both maternal and fetal sources. Rising estrogen plasma levels during pregnancy activate the placental RAAS, with concurrent increases in angiotensinogen (AGT) and renin levels (110, 114, 120, 132). Compared to the chorionic villi, the maternal decidua produces greater amounts of both total and active renin (114, 123).…”

Section: The Autonomic Regulation Of Cardiovascular Physiological Adamentioning

confidence: 99%

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Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

2016

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Preeclampsia (PE) is a form of gestational hypertension that complicates ~ 5 percent of pregnancies worldwide. Over 70 percent of the fatal cases of PE are attributed to cerebral edema, intracranial hemorrhage, and eclampsia. The etiology of PE originates from abnormal remodeling of the maternal spiral arteries, creating an ischemic placenta that releases factors that drive the pathophysiology. An initial neurological outcome of PE is the absence of the autonomically regulated cardiovascular adaptations to pregnancy. PE patients exhibit sympathetic overactivation, in comparison to both normotensive pregnant and hypertensive non-pregnant females. Moreover, PE diminishes baroreceptor reflex sensitivity (BRS) beyond that observed in healthy pregnancy. The absence of the cardiovascular adaptations to pregnancy, combined with sympathovagal imbalance and a blunted BRS leads to life-threatening neurological outcomes. Behaviorally, the increased incidences of maternal depression, anxiety, and post-traumatic stress disorder (PTSD) in PE are correlated to low fetal birth weight, intrauterine growth restriction (IUGR) and premature birth. This review addresses these neurological consequences of PE that present in the gravid female both during and after the index pregnancy.

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Section: The Autonomic Regulation Of Cardiovascular Physiological Adamentioning

confidence: 69%

Section: The Autonomic Regulation Of Cardiovascular Physiological Adamentioning

confidence: 99%

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

2016

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“…A research conducted by Kanda et al, on HRMECs concluded that there was a correlation between the activity of (P)RR and angiogenesis on diabetic retinopathy. The elevation of protein concentration would increase the level of VEGF mRNA expression [11,31]. Binding of prorenin with (P)RR would stimulate ERK phosphorylation, also it will trigger an action without involving angiotensin 1.…”

Section: Discussionmentioning

confidence: 99%

Correlation of (Pro)renin Receptor and Vascular Endothelial Growth Factor Expression Level in Third Trimester of Preeclampsia Placentas

Marissa¹,

Jusman²,

Purwosunu³

et al. 2018

Asian J Pharm Clin Res

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Objective:This cross-sectional study was designed to correlate the expression of mRNA and protein of (pro)renin receptor ([P]RR) and vascular endothelial growth factor (VEGF) gene in preeclampsia placentas. Methods:We used 34 placenta tissues of normal pregnancy and 34 preeclampsia placenta tissues. Real-time polymerase chain reaction was used to measure relative expression of VEGF and (P)RR mRNAs, and protein concentration was measured using Sandwich ELISA technique.Results: VEGF mRNA relative expression of preeclampsia placenta was 2.83 times higher than the normal placenta (p=0.02). (P)RR mRNA relative expression on preeclampsia placenta was 1.7 times higher than the normal one (p=0.039). Expression of protein (P)RR and VEGF was lower on preeclampsia shown by p<0.05, R=0.441. From this research, it was considered that low protein of (P)RR and VEGF contributes to preeclampsia. Conclusion:There was a correlation between (P)RR and VEGF. It considers that there is any involvement of (P)RR on angiogenesis through VEGF expression in preeclampsia placenta.

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“…67 A subsequent study found higher placental PRR expression and plasma sPRR levels in preeclamptic women; systolic BP positively correlated with placental PRR but not plasma sPRR. 68 Although plasma prorenin/renin levels were not measured, these findings raise the possibility of placental PRR-mediated RAS activation in preeclampsia. Recently, Sugulle et al 69 examined maternal blood samples for prorenin, renin, and sPRR in a group of preeclamptic, diabetic, and healthy pregnant women.…”

Section: Role Of the Prr In Bp Regulationmentioning

confidence: 93%

“…79 Plasma sPRR levels are elevated in patients who have chronic heart failure with reduced ejection fraction and are even greater in patients who have concomitant heart failure and renal dysfunction. 80 Finally, elevated plasma sPRR levels occur in preeclampsia 68 and obstructive sleep apnea. 81 Thus plasma sPRR levels may be of pathologic significance and/or could be of value as a biomarker in the development and progression of kidney and cardiovascular disease.…”

Section: Role Of the Prr In Bp Regulationmentioning

confidence: 99%

The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome

Ramkumar

Kohan

2019

Kidney International

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The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/ renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/ß catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.

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Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia

Cited by 46 publications

References 23 publications

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

Correlation of (Pro)renin Receptor and Vascular Endothelial Growth Factor Expression Level in Third Trimester of Preeclampsia Placentas

The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome

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