Placental Perfusion MR Imaging with Contrast Agents in a Mouse Model

Abstract

Placental perfusion can be calculated by using dynamic contrast-enhanced MR imaging, as shown in this mouse model.

IL-1 Receptor Antagonist Protects against Placental and Neurodevelopmental Defects Induced by Maternal Inflammation

“…Few studies have used MRI to characterize normal and pathological placentas in rodents and humans (48)(49)(50). We show that T 2 -weighted MRI without administration of contrast agent, a safe MRI technique routinely and efficiently applied in second-and third-trimester pregnant women to detect fetal malformations, is a useful diagnostic tool to detect experimentally induced placental inflammation in rodents.…”

SPIO‐enhanced magnetic resonance imaging study of placental perfusion in a rat model of intrauterine growth restriction

“…8 Magnetic resonance imaging (MRI) is being increasingly used as a diagnostic tool in human pregnancy, and recent reports suggest that it may provide important information on placental function. [9][10][11][12][13] Perfusion can be measured in several ways with MRI, including arterial spin labelling (ASL), echo planar imaging (EPI), and intravoxel incoherent motion (IVIM). [14][15][16] We have previously described a novel MRI-based approach to study placental function in a living mouse model, based on the use of gadolinium contrast agents and dynamic contrast enhancement (DCE) MRI.…”

“…[14][15][16] We have previously described a novel MRI-based approach to study placental function in a living mouse model, based on the use of gadolinium contrast agents and dynamic contrast enhancement (DCE) MRI. This has the capacity to measure placental perfusion and permeability in both physiological and pathological settings; 10,[12][13][14][15][16] however, gadolinium is not recommended for use during human pregnancy.…”

Magnetic resonance imaging of hypoxic injury to the murine placenta

“…MRI studies of placental anatomy and perfusion have been conducted in different species (16,29,31,35,36,44,51). Contrast agents (typically gadolinium-based chelates) were noted to easily cross the placental barrier in both the mouse and human placenta, and appeared in the fetal bladder soon after maternal intravenous administration (8,49,52).…”