Placental pathology of term singleton live births conceived with fresh embryo transfer compared with those conceived without assisted reproductive technology

Sacha, Caitlin R.; Mortimer, Roisin; James, Kaitlyn; Harris, Amy L.; Yeh, John; Toth, Thomas L.; Souter, Irene; Roberts, Drucilla J.

doi:10.1016/j.fertnstert.2021.12.017

Cited by 12 publications

(2 citation statements)

References 43 publications

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“…Over eight million babies worldwide have been conceived using Assisted Reproductive Technologies (ART). Although the vast majority of babies are born healthy, ART pregnancies are at increased risk for several complications, specifically low birth weight, stillbirth, preterm birth, and abnormal placentation, which includes increased risk for preeclampsia and morbidly adherent placentas ( Daniel et al, 1999 ; Schieve et al, 2007 ; Wisborg et al, 2010 ; Haavaldsen et al, 2012 ; Pandey et al, 2012 ; Marino et al, 2014 ; Luke et al, 2017 , 2019 ; Stern et al, 2018 ; Sacha et al, 2022 ). ART pregnancies are also at increased risk for rare imprinting disorders that severely affect development ( DeBaun et al, 2003 ; Gicquel et al, 2003 ; Ludwig et al, 2005 ; Hiura et al, 2012 ; Mussa et al, 2017 ; Cortessis et al, 2018 ; Johnson et al, 2018 ; Uk et al, 2018 ; Hattori et al, 2019a ; Henningsen et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Placental Abnormalities are Associated With Specific Windows of Embryo Culture in a Mouse Model

Vrooman

Rhon‐Calderón

Suri

et al. 2022

Front. Cell Dev. Biol.

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Assisted Reproductive Technologies (ART) employ gamete/embryo handling and culture in vitro to produce offspring. ART pregnancies have an increased risk of low birth weight, abnormal placentation, pregnancy complications, and imprinting disorders. Embryo culture induces low birth weight, abnormal placental morphology, and lower levels of DNA methylation in placentas in a mouse model of ART. Whether preimplantation embryos at specific stages of development are more susceptible to these perturbations remains unresolved. Accordingly, we performed embryo culture for several discrete periods of preimplantation development and following embryo transfer, assessed fetal and placental outcomes at term. We observed a reduction in fetal:placental ratio associated with two distinct windows of preimplantation embryo development, one prior to the morula stage and the other from the morula to blastocyst stage, whereas placental morphological abnormalities and reduced imprinting control region methylation were only associated with culture prior to the morula stage. Extended culture to the blastocyst stage also induces additional placental DNA methylation changes compared to embryos transferred at the morula stage, and female concepti exhibited a higher loss of DNA methylation than males. By identifying specific developmental windows of susceptibility, this study provides a framework to optimize further culture conditions to minimize risks associated with ART pregnancies.

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Section: Introductionmentioning

confidence: 99%

Placental Abnormalities are Associated With Specific Windows of Embryo Culture in a Mouse Model

Vrooman

Rhon‐Calderón

Suri

et al. 2022

Front. Cell Dev. Biol.

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“…[33][34][35][36] Conception with ART is also associated with an increased risk of placental pathology during the ensuing pregnancy. 37 The mechanism for this association is not clear, but it is tempting to speculate that adenomyosis may be more prevalent among patients undergoing in vitro fertilization due to its association with subfertility. Therefore, it is possible that our results may partly explain the observed association between ART and placental pathology.…”

Section: Ta B L Ementioning

confidence: 99%

The association between uterine adenomyosis and adverse obstetric outcomes: A propensity score‐matched analysis

Mandelbaum

Melville

Violette

et al. 2023

Acta Obstet Gynecol Scand

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Introduction This study examined obstetric outcomes in patients diagnosed with uterine adenomyosis. Material and methods This historical cohort study queried the Healthcare Cost and Utilization Project's National Inpatient Sample. The study population was all hospital deliveries in women aged 15–54 years between January 2016 and December 2019. The exposure was a diagnosis of uterine adenomyosis. The main outcome measures were obstetric characteristics, including placenta previa, placenta accreta spectrum, and placental abruption. Secondary outcomes were delivery complications including severe maternal morbidity. Analytic steps to assess these outcomes included (i) a 1‐to‐N propensity score matching to mitigate and balance prepregnancy confounders to assess obstetric characteristics, followed by (ii) an adjusting model with preselected pregnancy and delivery factors to assess maternal morbidity. Sensitivity analyses were also performed with restricted cohorts to account for prior uterine scar, uterine myoma, and extra‐uterine endometriosis. Results After propensity score matching, 5430 patients with adenomyosis were compared to 21 720 patients without adenomyosis. Adenomyosis was associated with an increased odds of placenta accreta spectrum (adjusted‐odds ratio [aOR] 3.07, 95% confidence interval [CI] 2.01–4.70), placenta abruption (aOR 3.21, 95% CI: 2.60–3.98), and placenta previa (aOR 5.08, 95% CI: 4.25–6.06). Delivery at <32 weeks of gestation (aOR 1.48, 95% CI: 1.24–1.77) and cesarean delivery (aOR 7.72, 95% CI: 7.04–8.47) were both increased in women with adenomyosis. Patients in the adenomyosis group were more likely to experience severe maternal morbidity at delivery compared to those in the nonadenomyosis group (aOR 1.86, 95% CI: 1.59–2.16). Results remained robust in the aforementioned several sensitivity analyses. Conclusions This national‐level analysis suggests that a diagnosis of uterine adenomyosis is associated with an increased risk of placental pathology (placenta accreta spectrum, placenta abruption, and placental previa) and adverse maternal outcomes at delivery.

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Comparative study of difference in anatomy & histopathology of placenta & umbilical cord in natural pregnancy vs. IVF pregnancy & it’s impact on fetal & maternal outcome

Bhardwaj,

Singh,

Kumar

et al. 2024

European Journal of Obstetrics & Gynecology and Reproductiv

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Placental pathology of term singleton live births conceived with fresh embryo transfer compared with those conceived without assisted reproductive technology

Cited by 12 publications

References 43 publications

Placental Abnormalities are Associated With Specific Windows of Embryo Culture in a Mouse Model

Placental Abnormalities are Associated With Specific Windows of Embryo Culture in a Mouse Model

The association between uterine adenomyosis and adverse obstetric outcomes: A propensity score‐matched analysis

Comparative study of difference in anatomy & histopathology of placenta & umbilical cord in natural pregnancy vs. IVF pregnancy & it’s impact on fetal & maternal outcome

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