Placental Pathology in Maternal and Neonatal Myeloproliferative Disorders

Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review

“…Malignancy involving the placenta is uncommon [3–27]; however, maternal malignancy during pregnancy, metastatic to the placenta or baby, is more common than fetal malignancy involving the placenta is. Al-Adnani and colleagues [3] reviewed 81 cases of metastatic maternal tumors to the placenta and/or baby reported in the English language literature.…”

“…Al-Adnani and colleagues [3] reviewed 81 cases of metastatic maternal tumors to the placenta and/or baby reported in the English language literature. We performed a comprehensive review of the English language literature and identified 32 other cases of fetal malignancy/TAM involving the placenta, with involvement specifically defined as circulating tumor cells and/or CV stromal infiltrates [4–27] (Table 1). The male to female ratio of all 33 cases was 0.94 (2 infants' genders not specified); 11 infants were stillborn, and an additional 14 were only briefly viable or died within the neonatal period (Table 1).…”

“…Congenital leukemia and trisomy 21-associated TAM are the second-most commonly identified neoplastic disorders with placental involvement [4,9,11,13,14,16,23,30] (11 of 33 cases; 33%) ( Table 2) and are evidenced by circulating blasts within the fetal vasculature, with or without CV stromal infiltration. Some authors have specified that the presence of CV stromal invasion, and not merely the presence of circulating neoplastic cells in the fetal vasculature, is required for the definition of true placental metastasis [10].…”