Placental pathology, birthweight discordance, and growth restriction in twin pregnancy: results of the ESPRiT Study

Kent, Etaoin; Breathnach, Fionnuala; Gillan, John; McAuliffe, Fionnuala M.; Geary, Michael; Daly, Seán; Higgins, John R.; Hunter, Alyson; Burke, Gerald; Higgins, Shane; Carroll, Stephen; Manning, Fiona; Tully, Elizabeth; Malone, Fergal D.

doi:10.1016/j.ajog.2012.06.022

Cited by 52 publications

(40 citation statements)

References 17 publications

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“…shows a higher incidence of infarctions, subchorial fibrin deposition, and abnormal villous maturation compared to DC twins (41.5% vs 32.9%; P ¼ .009). 78,79 MC twins present also with a higher incidence of fetal vessels thrombosis compared to DC. 80 Fetal vascular thrombosis is found generally in association with IUGR in MC twins and with hypertensive disorders in DC twins.…”

Section: Obstetrics Expert Reviewsmentioning

confidence: 91%

Anomalies of the placenta and umbilical cord in twin gestations

Hubinont¹,

Lewi

Bernard³

et al. 2015

American Journal of Obstetrics and Gynecology

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Section: Obstetrics Expert Reviewsmentioning

confidence: 91%

Anomalies of the placenta and umbilical cord in twin gestations

Hubinont¹,

Lewi

Bernard³

et al. 2015

American Journal of Obstetrics and Gynecology

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“…However, these effects vary between populations [20,21]. It has been reported that placental factors alone contribute to neonatal growth retardation in 36% of LBW cases [12,22]. Placental factors include changes in placental morphology and insults to the placenta such as infarcts, chronic villous inflammation, and vascular vessel thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Maternal Demographic and Placental Risk Factors in Term Low Birth Weight in Ghana

Aleksenko

Tettey

Richard³

et al. 2017

J Preg Child Health

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“…This study indicated a correlation between placental abnormalities with birth weight discrepancy and intrauterine growth restriction in dichorionic twins. On the other hand, no such association was observed in monochorionic twin pregnancies [9].…”

Section: Etiologymentioning

confidence: 71%

“…In retrospective studies the threshold range from 10 to 30% [4,5,9,[19][20][21][22][23][24] (Table 1). According to the American College of Obstetricians and Gynecologists [27] an EFW disparity of approximately 15-25% is considered to be clinically significant, whereas the UK National Institute for Health and Care Excellence guidelines [28] set the threshold at the level of 25% and recommend the referral of such pregnancies to a tertiary fetal medicine center.…”

Section: Estimated Fetal Weight Discordance and Perinatal Outcomementioning

confidence: 99%

“…In a large, multicenter, prospective study (ESPRiT) [9] of twin pregnancies, the association between placental histological abnormalities, birthweight discordance and growth restriction was examined. This study indicated a correlation between placental abnormalities with birth weight discrepancy and intrauterine growth restriction in dichorionic twins.…”

Section: Etiologymentioning

confidence: 99%

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Intertwin estimated fetal weight or crown rump length discordance and adverse perinatal outcome

Kaponis

Thanatsis

Papadopoulos

et al. 2015

Journal of Perinatal Medicine

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Aim: In the current review study, we present recent data regarding the importance of intertwin estimated fetal weight (EFW) and crown rump length (CRL) discordance for the prediction of adverse perinatal outcome both in monochorionic and in dichorionic diamniotic gestations. Results: Twins with significant weight disparity are associated with higher rates of perinatal morbidity and mortality, regardless of gestational age at delivery. However, there is no agreement regarding as to the cut off value above which the perinatal outcome is unfavorably affected and the threshold range from 10 to 30%. On the other hand, CRL discrepancy has proved to be a weak predictor of adverse outcomes, such as fetal or neonatal death in fetuses without chromosomal and structural abnormalities. In clinical practice, decisions about obstetric surveillance of discordant twin gestations, frequency of fetal sonographic monitoring and time of delivery are usually based on amniotic fluid volume and Doppler assessments on a weekly basis. Conclusion: Significant EFW discordance leads to adverse perinatal outcome, although the cut-off value has not yet been estimated. CRL discrepancy is not correlated well with adverse perinatal outcome. However, increased monitoring of women with EFW and CRL discrepancy is suggested.

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Placental pathology, birthweight discordance, and growth restriction in twin pregnancy: results of the ESPRiT Study

Cited by 52 publications

References 17 publications

Anomalies of the placenta and umbilical cord in twin gestations

Anomalies of the placenta and umbilical cord in twin gestations

Maternal Demographic and Placental Risk Factors in Term Low Birth Weight in Ghana

Intertwin estimated fetal weight or crown rump length discordance and adverse perinatal outcome

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