Placental pathologic features in obesity

Beneventi, Fausta; Bellingeri, Camilla; De Maggio, Irene; Cavagnoli, Chiara; Fumanelli, Silvia; Ligari, Elisa; Fiandrino, Giacomo; Cesari, Stefania; Spinillo, Arsenio

doi:10.1016/j.placenta.2023.10.011

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Pathologically, the rate of maternal placental vascular lesions was higher in women with obesity than in women with normal weight [ 42 ]. Maternal obesity was significantly associated with both maternal- and fetal overall vascular malperfusion, inflammatory lesions, and villitis [ 43 ]. As placenta is a fetal tissue, it exhibits sexual dimorphism.…”

Section: Changed Placenta In Maternal Obesitymentioning

confidence: 99%

Maternal obesity and placental function: impaired maternal–fetal axis

Louwen,

Kreis,

Ritter

et al. 2024

Arch Gynecol Obstet

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The prevalence of maternal obesity rapidly increases, which represents a major public health concern worldwide. Maternal obesity is characteristic by metabolic dysfunction and chronic inflammation. It is associated with health problems in both mother and offspring. Increasing evidence indicates that the placenta is an axis connecting maternal obesity with poor outcomes in the offspring. In this brief review, we have summarized the current data regarding deregulated placental function in maternal obesity. The data show that maternal obesity induces numerous placental defects, including lipid and glucose metabolism, stress response, inflammation, immune regulation and epigenetics. These placental defects affect each other and result in a stressful intrauterine environment, which transduces and mediates the adverse effects of maternal obesity to the fetus. Further investigations are required to explore the exact molecular alterations in the placenta in maternal obesity, which may pave the way to develop specific interventions for preventing epigenetic and metabolic programming in the fetus.

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Section: Changed Placenta In Maternal Obesitymentioning

confidence: 99%

Maternal obesity and placental function: impaired maternal–fetal axis

Louwen,

Kreis,

Ritter

et al. 2024

Arch Gynecol Obstet

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Value of Cerebroplacental Ratio in Predicting Adverse Perinatal Outcome in Term Pregnancies Complicated by Obesity

Eisenkolb,

Karge,

Ortiz

et al. 2024

Geburtshilfe Frauenheilkd

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To evaluate the performance of cerebroplacental ratio (CPR) in predicting composite adverse perinatal outcome (CAPO) in women with obesity compared to non-obese women at term.This is a retrospective cohort study in a single tertiary referral centre over a 3-year period. All singleton pregnancies with CPR measurements ≥ 37 + 0 weeks and estimated fetal weight ≥ 10th centile and attempted vaginal delivery were included and divided into two groups defined by pre-pregnancy body mass index (BMI) </≥ 30 kg/m2. The presence of at least one of the following outcome parameters was defined as CAPO: operative delivery (OD) due to intrapartum fetal compromise (IFC), admission to the neonatal intensive care unit, umbilical cord arterial pH ≤ 7.15, 5 min Apgar < 7. The prognostic performance of CPR MoM was evaluated using receiver operating characteristic (ROC) analysis.The study cohort included 1207 pregnancies, of which 112 were women with a BMI ≥ 30 kg/m2. In obese women, CAPO occurred in 21 cases (18.8%) compared to 247 (22.6%) cases in women with BMI < 30 kg/m2 (p = 0.404). In the entire study cohort, CPR MoM was significantly lower in the CAPO and OD for IFC group. ROC analyses revealed a significant predictive value of low CPR MoM for CAPO in obese women (AUC = 0.64, p = 0.024). Furthermore, CPR was predictive for OD for IFC not only in obese (AUC = 0.72, p = 0.023) but also in non-obese (AUC = 0.61, p = 0.003) women.Low CPR MoM was predictive for CAPO and OD for IFC in obese women without additional risk factors. However, the overall predictive performance of CPR for CAPO in obese women was poor.

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Placental pathologic features in obesity

Cited by 2 publications

References 39 publications

Maternal obesity and placental function: impaired maternal–fetal axis

Maternal obesity and placental function: impaired maternal–fetal axis

Value of Cerebroplacental Ratio in Predicting Adverse Perinatal Outcome in Term Pregnancies Complicated by Obesity

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