Placental Passage of Protopine in an Ex Vivo Human Perfusion System

Spiess, Deborah; Abegg, Vanessa Fabienne; Chaveau, Antoine; Treyer, Andrea; Oufir, Mouhssin; Reinehr, Michael; Duong, Elisa; Potterat, Olivier; Hamburger, Matthias; Simões-Wüst, Ana Paula

doi:10.1055/a-1829-9546

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…It is possible that the potential embryonic developmental toxicity of MPTA also affects the levels of estrogen in rats. The results of another study also showed that PRO can be transferred from the mother to the fetal circuit and reach homeostasis through the placental barrier ( Spiess et al, 2022a ). This also provides a partial explanation for the potential embryotoxicity risk of PRO, but the cause of embryotoxicity due to MPTA and its safety for target animals should still be further investigated.…”

Section: Discussionmentioning

confidence: 96%

Acute, chronic, and genotoxic studies on the protopine total alkaloids of the Macleaya cordata (willd.) R. Br. in rodents

Dong

Tang

et al. 2022

Front. Pharmacol.

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The protopine alkaloids are widely distributed within the opium poppy family and have a wide range of pharmacological effects. MPTA is a product of the protopine total alkaloids extracted from the Macleaya cordata (Willd.) R. Br. Previously, we reported good anti-inflammatory activity of MPTA as well as oral acute and sub-chronic toxicity studies in rats. In order to perform a systematic toxicological safety assessment of MPTA, oral acute toxicity, genotoxicity (bone marrow cell chromosome aberration test, sperm abnormality test, bone marrow cell micronucleus test, and rat teratogenicity test), and chronic toxicity in mice were performed in this study. In the oral acute toxicity test, the LD50 in ICR mice was 481.99 mg/kg, with 95% confidence limits ranging from 404.27 to 574.70 mg/kg. All three mutagenicity tests tested negative in the range of 60.25–241.00 mg/kg. The results of the teratogenicity test in rats showed no reproductive or embryonic developmental toxicity at only 7.53 mg/kg, which can be considered as a no observed effect level (NOEL) for the teratogenicity test. Therefore, MPTA is safe for use at the doses tested, but attention should be paid to the potential risk to pregnant animals and the safety evaluation and toxicity mechanisms in target animals should be further investigated.

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Section: Discussionmentioning

confidence: 96%