Placental oxidative DNA damage and its repair in preeclamptic women with fetal growth restriction

Fujimaki, A.; Watanabe, Kazushi; Mori, Toshitaka; Kimura, Chiharu; Shinohara, Koichi; Wakatsuki, Akihiko

doi:10.1016/j.placenta.2011.02.004

Cited by 72 publications

(51 citation statements)

References 38 publications

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“…The PE group, however, showed no statistically significant difference from control (Wiktor et al 2004). Other studies on the same subject showed similar conclusions, with oxidative stress levels being higher in the groups that exhibit both pathologies (Fujimaki et al 2011;Mert et al 2012). These findings suggest a correlation be-tween the severity of the deficiency in the interaction between cytotrophoblasts and the maternal spiral arteries, both representative of IUGR and PE, and the levels of oxidative stress (Wiktor et al 2004).…”

Section: Intrauterine Growth Restrictionsupporting

confidence: 69%

“…PE can have an early-onset development, when it is manifested before 34 weeks of gestation, or a late onset, if it develops after the 34th week of gestation (Agarwal et al 2012). One of the basic pathological events is maternal vascular endothelial injury, which may favor the production of vasoconstrictors, resulting in vasospasms, very common in PE (Agarwal et al 2012;Fujimaki et al 2011).…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

“…Despite having distinctive clinical manifestations, there is accumulating evidence that the two pathologies have a common cause: an abnormal placental implantation (Mert et al 2012). Several studies have been conducted in order to understand if the two pathologies are related (Fujimaki et al 2011;Mert et al 2012;Takagi et al 2004;Wiktor et al 2004). One study, using immunohistochemistry and Western blotting in tissue samples from normal and PE placentas, suggested that the oxidative damage was higher in placenta displaying PE together with IUGR when compared with placenta displaying PE alone (Takagi et al 2004).…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

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Oxidative stress in pregnancy and fertility pathologies

Pereira

Martel

2014

Cell Biol Toxicol

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Oxidative stress designates the state of imbalance between reactive oxygen species (ROS) production and antioxidant levels. In a healthy placenta, there is an increase in ROS production, due to formation of new tissues and inherent metabolism, but this is balanced by higher levels of antioxidants. However, this balance is lost in some situations, with a consequent increase in oxidative stress levels. Oxidative stress has been implicated in several placental disorders and pregnancy pathologies. The present review intends to summarize what is known about the relationship between oxidative stress and well-known pregnancy disorders.

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Section: Intrauterine Growth Restrictionsupporting

confidence: 69%

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

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Oxidative stress in pregnancy and fertility pathologies

Pereira

Martel

2014

Cell Biol Toxicol

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“…In preeclampsia, the lower fetal weight at birth can be the result of both fetal growth restriction and preterm delivery; this is well described in the literature. At the same time, fetal growth restriction may be also consequence of the increased oxidative stress in those women with preeclampsia; this has also been suggested in other studies, such as Fujimaki et al 31 Regarding nitric oxide levels in preeclampsia or in other hypertensive disorders, the results of different studies are contradictory; both elevated and diminished levels have been found. 32,33 We found a significant increment in nitrate levels in preeclampsia and similar levels in the other hypertensive groups when compared with PCW.…”

Section: Discussionmentioning

confidence: 73%

Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy

et al. 2011

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Increased levels of oxidative stress have been demonstrated in Preeclampsia in previous studies, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). We measured different markers of lipid peroxidation and antioxidant defenses by spectrophotometry or enzymoimmunoanalysis in 339 pregnant women: 85 with gestational hypertension (GH), 88 chronic hypertension (CH), 104 Preeclampsia and 62 healthy pregnant control women (PCW). Lower activity of superoxide dismutase and higher levels of catalase were found in GH, CH and preeclampsia compared with PCW (964.4±116.5, 970.0±120.4, 971.2±137.5 and 1063.4±133.7 U g À1 Hb, Po0.001; and 313.0±71.7, 292.2±45.3, 297.1 ± 47.2, 215.5 ± 26.2 U mg À1 Hb, Po0.0001; respectively). Regarding the glutathione REDOX cycle, we found the following in GH, CH and preeclampsia compared with PCW: a decrease in its reduced form (2.6 ± 0.6, 2.7 ± 0.8, 2.7 ± 0.9, 3.3±1.3 lmol l À1 , Po0.003), a parallel increase in the oxidized form (185.6±68.9, 194.7±75.0, 184.3±78.3, 85.1±27.5 lmol l À1 , Po0.0001) and an increment in glutathione peroxidase (85.9±22.0, 86.4±20.9, 82.1±23.5 and 77.2 ± 19.7 U g À1 Hb, Po0.04) and glutathione reductase (6384.3 ± 1261.9, 6724.6 ± 1154.1, 6287.9 ± 1399.9 and 6044.4±1208.4 mU g À1 Hb, Po0.01, respectively). Nitrites/nitrates were higher in patients with preeclampsia than in PCW (31.50±15.08, 26.80±8.39 lmol l À1 , Po0.002). Although malondialdehyde and oxidized-LDL levels were similar among groups, free fatty acids were increased in every HDP (GH 514.6 ± 194.6, CH 501.3 ± 197.4, preeclampsia 555.2 ± 230.1 lmol l À1 ) compared with PCW (351.4 ± 146.1 lmol l À1 ), Po0.0001. Our results show an oxidation/reduction imbalance with an increase in oxidative stress coupled with a decreased capacity of antioxidant systems, not only in preeclampsia but also in every HDP.

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“…The d-ROMs level in pregnant women is reported to increase at the end of pregnancy even if they don't have any complications, compared with the nonpregnancy period [16] [17] [18], while the d-ROMs level during delivery is pointed out to become higher than 600 U.CARR [19]. A previous study [20] had already described that the d-ROMs levels were higher during the first 0 -2 postpartum days, but it was found out that they were still high at 3 months after giving birth.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers

Kuramoto¹,

Kitagawa²

2017

Health

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Purpose: The purpose of this study was to evaluate oxidative stress, antioxidant power, and antioxidant potential of breastmilk of breast-feeding mothers from the early postpartum period to the first 3 months postpartum, and to examine the dynamics and the relationships among them. Method: For 47 puerperant women who gave vaginal birth without any pregnancy complications, the oxidative stress levels (d-ROMs levels) and antioxidant power (BAP levels) in the maternal plasma as well as antioxidant potential of breastmilk (BAP levels in breastmilk) were measured 3 times, i.e., in the early puerperium (4 or 5 days after giving birth), one month after giving birth, and 3 months after giving birth. Results: The d-ROMs levels in the maternal plasma were significantly high in the early puerperium (p < 0.001), and decreased gradually in the postpartum period (p < 0.001). On the other hand, BAP levels were significantly low in the early puerperium (p < 0.001), and increased to the almost normal level during one month after giving birth. BAP levels in breastmilk were significantly high in the early puerperium compared with the other periods (p < 0.001), and decreased gradually until 3 months after giving birth (p < 0.001). BAP levels in breastmilk in the early puerperium were higher compared with the maternal BAP levels, and there was a positive correlation between BAP levels in breastmilk and those in the maternal plasma (p < 0.05). Discussion: Regarding the oxidative stress and the antioxidant defense system of breast-feeding mothers, the d-ROMs level was highest and the BAP level was lowest in the early puerperium. The BAP level then showed a clear tendency to recover in the first 3 months after giving birth. Conclusion: When the maternal antioxidant potential remains at a low level after giving birth, careful consideration should be given to the mother's health and wellbeing How to cite this paper:

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Placental oxidative DNA damage and its repair in preeclamptic women with fetal growth restriction

Cited by 72 publications

References 38 publications

Oxidative stress in pregnancy and fertility pathologies

Oxidative stress in pregnancy and fertility pathologies

Abnormal levels of antioxidant defenses in a large sample of patients with hypertensive disorders of pregnancy

Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers

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