Placental mitochondria as a source of oxidative stress in pre-eclampsia

Wang, Y.; Walsh, Scott W.

doi:10.1016/s0143-4004(98)90018-2

Cited by 244 publications

(150 citation statements)

References 24 publications

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“…Cumulative evidence in recent years has shown that a biochemical imbalance in preeclampsia occurs with an increase of oxidative stress and lipoperoxidation and, at the same time, a deficient antioxidant protection (24).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress is closely related to clinical severity of pre-eclampsia

et al. 2006

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Pre-eclampsia is a hypertensive disorder of pregnancy in which enzymatic antioxidant defenses fail and tissues are injured. This prospective case-control study evaluated whether pre-eclamptic women and their newborns show higher degrees of oxidative stress than normal pregnancies and sought to determine if this stress is related to clinical severity. Forty-four pre-eclamptic and thirty healthy pregnant women attending two hospitals in Valparaíso, Chile, were studied. The following plasmatic variables of antioxidant capacity were evaluated: glutathione peroxidase activity (GPx), total antioxidant capacity measured by oxidation of ABTS substrate (2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid), and superoxide dismutase activity (SOD). malondialdehide (MDA) was measured to evaluate lipoperoxidation. The evaluation was performed at diagnosis of pre-eclampsia, delivery, 30 days and 120 days post delivery. Newborns were studied at delivery through umbilical cord blood samples. Our analysis shows that antioxidant enzyme activity (SOD, GPx, ABTS) was significantly decreased, while lipoperoxidation (MDA) was increased in both pre-eclamptic groups compared to normal pregnant women (p<0.01). Statistically significant difference was found between mild and severe pre-eclamptic groups (p<0.01), for all biochemical markers studied. Therefore, the clinical severity of this pathology is closely related to the degree of oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress is closely related to clinical severity of pre-eclampsia

et al. 2006

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“…Cumulative evidences in recent years show that a biochemical imbalance in preeclampsia occurs with an increase of oxidative stress and a deficient antioxidant protection [21,22,23]. Uncontrolled peroxidation alters membrane fluidity and permeability, therefore the lipid peroxides and their secondary metabolites, such as malondialdehyde (MDA, a good indicator of oxidant forces formed at a primary site), are then transported through the circulation by lipoproteins, causing damage at distant tissues.…”

Section: Discussion:-mentioning

confidence: 99%

To Determine the Levels of Free-Fatty Acid, Lipid-Peroxidation and the Role of Non- Enzymatic Antioxidant in Pre-Eclampsia Compared With Normal Pregnancy.

Dwivedi¹,

Singh²,

Chowdhary³

2017

IJAR

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“…It is thought that the placenta is a major source of oxidative stress in pregnant females (Gitto et al 2002, Myatt and Cui 2004, Hung et al 2010. A significant part of the total indicators of pregnancy-related oxidative stress may derive from the placenta's mitochondrial mass, which increases with gestational age (Wang and Walsh 1998). Mitochondria are considered primary generators of superoxide anions (O -2 ), the major ROS molecule (Cadenas et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Szczubiał¹,

Kankofer²,

Dąbrowski³

et al. 2015

Polish Journal of Veterinary Sciences

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The aim of the study was to investigate oxidative stress during normal pregnancy in female dogs based on an evaluation of plasma markers for lipid and protein peroxidation. Twenty clinically healthy female dogs (10 non-pregnant and 10 pregnant) were used in the study. Blood samples from the pregnant animals were collected at 19-21, 38-40, and 56-58 days of pregnancy. Blood samples from non-pregnant female dogs were obtained between 20 and 35 days after ineffective breeding. As indicators of oxidative stress, we measured the following using spectrophotometric and spectrofluorimetric methods: thiobarbituric acid reactive substances (TBARS), radical cations of N,N, diethylpara-phenylene diamine (RC-DEPPD), sulfhydryl groups (SH groups), bityrosine and formylkynurenine. The mean plasma TBARS concentration in the pregnant dogs (0.486 ± 0.071 -0.581 ± 0.191 μmol/g protein) was significantly higher (p<0.05) than that found in the non-pregnant animals (0.274 ± 0.111 μmol/g protein). A marked, although not significant, decrease in SH group content, as well as an increase in bityrosine and formylkynurenine concentration were concurrently observed in the pregnant dogs. No significant differences were found in terms of the studied markers in the pregnant animals when comparing the values obtained during the investigated periods of pregnancy, although there was a progressive decrease in TBARS concentration and a progressive increase in RC-DEPPD, bityrosine and formylkynurenine contents. Our findings suggest that normal pregnancy in female dogs is associated with oxidative stress. Further studies are necessary to establish the physiological ranges of antioxidative/oxidative profiles in pregnant dogs and to explain if and how the intensity of oxidative stress might contribute to the risk of the complications of pregnancy.

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Placental mitochondria as a source of oxidative stress in pre-eclampsia

Cited by 244 publications

References 24 publications

Oxidative stress is closely related to clinical severity of pre-eclampsia

Oxidative stress is closely related to clinical severity of pre-eclampsia

To Determine the Levels of Free-Fatty Acid, Lipid-Peroxidation and the Role of Non- Enzymatic Antioxidant in Pre-Eclampsia Compared With Normal Pregnancy.

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

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