Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes

Prieto-Sánchez, María T; Ruiz-Palacios, María; Blanco-Carnero, José Eliseo; Pagán, Ana; Hellmuth, Christian; Uhl, Olaf; Peißner, Wolfgang; Ruiz–Alcaraz, Antonio J.; Parrilla, Juan José; Koletzko, Berthold; Larqué, Elvira

doi:10.1016/j.clnu.2016.01.014

Cited by 93 publications

(73 citation statements)

References 29 publications

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“…The role of LPC in the fetal metabolism is unexplored, although their role in fatty acid transport from maternal circulation into the placenta is of growing interest [32]. Our study demonstrated strong positive associations of cord blood LPC, in particular monounsaturated species, to birth weight, but no relation to the maternal factors pre-pregnancy BMI, gestational weight gain, and gestational diabetes.…”

Section: Discussionmentioning

confidence: 49%

Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development

Hellmuth

Uhl²,

Standl³

et al. 2017

Obes Facts

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Background/Aims: Fetal metabolism may be changed by the exposure to maternal factors, and the route to obesity may already set in utero. Cord blood metabolites might predict growth patterns and later obesity. We aimed to characterize associations of cord blood with birth weight, postnatal weight gain, and BMI in adolescence. Methods: Over 700 cord blood samples were collected from infants participating in the German birth cohort study LISAplus. Glycerophospholipid fatty acids (GPL-FA), polar lipids, non-esterified fatty acids (NEFA), and amino acids were analyzed with a targeted, liquid chromatography-tandem mass spectrometry based metabolomics platform. Cord blood metabolites were related to growth factors by linear regression models adjusted for confounding variables. Results: Cord blood metabolites were highly associated with birth weight. Lysophosphatidylcholines C16:1, C18:1, C20:3, C18:2, C20:4, C14:0, C16:0, C18:3, GPL-FA C20:3n-9, and GPL-FA C22:5n-6 were positively related to birth weight, while higher cord blood concentrations of NEFA C22:6, NEFA C20:5, GPL-FA C18:3n-3, and PCe C38:0 were associated with lower birth weight. Postnatal weight gain and BMI z-scores in adolescents were not significantly associated with cord blood metabolites after adjustment for multiple testing. Conclusion: Potential long-term programming effects of the intrauterine environment and metabolism on later health cannot be predicted with profiling of the cord blood metabolome.

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Section: Discussionmentioning

confidence: 49%

Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development

Hellmuth

Uhl²,

Standl³

et al. 2017

Obes Facts

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“…Unlike other fatty acid transporters, our group found lower levels of FATP-4 and MFSD2A expression in GDM placentas [57]. Moreover, Soygur et al [78] confirmed a reduction in MFSD2A in GDM placentas.…”

Section: The Effects Of Insulin On Placental Lipids Transport In Gdmmentioning

confidence: 70%

“…Numerous membrane-bound proteins are expressed in the trophoblast, including fatty acid binding protein (FABP) plasma membrane, FAT/CD36 (fatty acid translocase), and FATP-1 to - 6 (fatty acid transport proteins) [56]. Recently, the presence of the major facilitator superfamily domain 2A (MFSD2A) transporter was reported in the placenta [57], which may enhance the transfer of lysophospholipids across the cell membrane [58]. Lysophospholipids could be an additional source of fatty acids for the placenta.…”

Section: The Effects Of Insulin On Placental Lipids Transport In Gdmmentioning

confidence: 99%

Role of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus

Ruiz-Palacios

Ruiz–Alcaraz²,

Sánchez-Campillo³

et al. 2017

Ann Nutr Metab

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Background: Gestational diabetes mellitus (GDM) is associated with increased fetal adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin receptors and maternal insulin can activate its signaling pathways, affecting the transport of nutrients to the fetus. However, the effects of diet or insulin treatment on the placental pathophysiology of GDM are unknown. Summary: There are very few studies on possible defects in the insulin signaling pathway in the GDM placenta. Such defects could influence the placental transport of nutrients to the fetus. In this review we discuss the state of insulin signaling pathways in placentas of women with GDM, as well as the role of exogenous insulin in placental nutrient transport to the fetus, and fetal adiposity. Key Messages: Maternal insulin in the third trimester is correlated with fetal abdominal circumference at that time, suggesting the important role of insulin in this process. Since treatment with insulin at the end of pregnancy may activate placental nutrient transport to the fetus and promote placental fatty acid transfer, it would be interesting to improve maternal hyperlipidemia control in GDM subjects treated with this hormone. More research in this area with high number of subjects is necessary.

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“…In particular, the transfer of docosahexaenoic acid (DHA) from the mother to the fetus has been found to be impaired in GDM [25] . Following observations in mice [26], the major facilitator super family domain containing 2a was identified as a preferred transporter of DHA in the human placenta [27] . This observation reinforced the hypothesis that a disturbed lipid metabolism, and not the glucose tolerance, is crucial in the fetal fat mass and subsequent adiposity onset [22][23][24] .…”

Section: Pregnancymentioning

confidence: 99%

Early Programming of Obesity Throughout the Life Course: A Metabolomics Perspective

et al. 2017

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Background: Over the last decades, research on early life risk factors for obesity and its comorbidities in early life has gained attention within the field of developmental origins of health and diseases. Metabolomics studies that are trying to find early life biomarker and intervention targets for the early development of obesity and associated cardiovascular diseases could help break the inter-generational cycle of obesity. Summary: Metabolomics studies in the field of early programming are scarce and causality is lacking at this stage, as most of the studies are cross-sectional. The main metabolites in the focus of obesity are branched-chain and aromatic amino acids, long-chain polyunsaturated fatty acids, lysophosphatidylcholines, and sphingomyelins. Sex and puberty have not been considered in most of the biomarker studies, but show differences in the metabolite associations to obesity. Key Messages: There is still a lot unknown about the associations between early programming exposures, metabolite concentrations, and the development of obesity. The few studies focusing on this topic find similar metabolite classes in the same age groups being associated with rapid early growth or obesity; but due to differences in the methodological and statistical approaches, the single species often differ. Therefore, more research, preferably with standardized approaches, is needed.

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Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes

Cited by 93 publications

References 29 publications

Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development

Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development

Role of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus

Early Programming of Obesity Throughout the Life Course: A Metabolomics Perspective

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