Placental mesenchymal dysplasia initially diagnosed as partial mole

Matsui, Hideo; Iitsuka, Yoshinori; Yamazawa, Koji; Tanaka, Naotake; Mitsuhashi, Akira; Seki, Kazuhiko; Sekiya, Souei

doi:10.1046/j.1440-1827.2003.01550.x

Cited by 64 publications

(43 citation statements)

References 13 publications

(26 reference statements)

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“…All articles without an abstract or with unavailable full text were excluded. We identified 49 articles including 110 cases of PMD [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. …”

Section: Literaturementioning

confidence: 99%

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Ohira¹,

Ookubo²,

Tanaka³

et al. 2013

Gynecol Obstet Invest

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Placental mesenchymal dysplasia (PMD) is characterized by multiple hypoechoic vesicles which are similar to molar changes in the placenta; however, the process of such morphological changes of PMD during pregnancy has not been fully understood. We performed a review of all PMD cases published in English and identified 49 articles including 110 cases. With regard to the gestational age at which the multicystic pattern was seen,approximately 70% of cases were diagnosed at 13-20 weeks of gestation. Another characteristic feature of PMD is varicose dilation of fetal chorionic vessels. As many as 90% of cases were diagnosed as placenta with dilated fetal chorionic vessels in the third trimester. We also report a case of PMD which was found at 10 weeks of gestation according to ultrasonic molar patterns. Serial observations of the placenta using ultrasound and magnetic resonance imaging revealed that multicystic lesions became smaller after 23 weeks. In contrast, dilated placental vessels on the fetal side became apparent at 38 weeks. The present review highlights that placental vesicular lesions of PMD may precede dilation of fetal chorionic vessels during pregnancy. It also indicates the potential of a gradual reduction in size of PMD's placental vesicular lesions by serial study of placental images.

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Section: Literaturementioning

confidence: 99%

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Ohira¹,

Ookubo²,

Tanaka³

et al. 2013

Gynecol Obstet Invest

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“…Un buen aporte al diagnóstico es la presencia de vasos arteriales con una gruesa capa muscular en el espesor del mesénquima mixomatoso de las vellosidades troncales (14). En nuestro caso la condición diploide de la placenta establecida por citometría de flujo descarta una mola parcial, el error diagnóstico más frecuentemente reportado (1,2,4,6,14) El rápido descenso en los títulos de ß-hCG en la DMP es similar a lo observado luego de un embarazo fisiológico. En cambio en los casos de enfermedad trofoblástica el descenso es más lento e incluso se han presentado casos de mola invasora que requirieron quimioterapia (12).…”

Section: Discussionunclassified

Displasia Mesenquimática Placentaria

et al. 2005

Rev. chil. obstet. ginecol.

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RESUMENReportamos el primer caso en Chile de displasia mesenquimática placentaria que coexistió con un feto sano y cuyo curso clínico demostró un exitoso resultado perinatal. Se revisa la literatura y se definen las claves del diagnóstico diferencial. PALABRAS CLAVE: Displasia mesenquimática placentaria SUMMARYThe first case in Chile of placental mesenchymal dysplasia is reported. The abnormal placenta coexisted with a normal fetus and the clinical course demostrated a successful perinatal outcome. The literature is reviewed and the keys of differential diagnoses are defined. KEY WORDS: Placental mesenchymal dysplasiaCasos Clínicos han descrito casos de mosaicismo con triploidía confinada sólo a la placenta (11). Se ha documentado también un caso en que una porción de la placenta muestra las características de una mola completa y mosaicismo consistente con diploidía diándrica en el segmento placentario comprometido y cariotipo normal biparental en el resto de la placenta y feto (12).El objetivo de esta comunicación es informar el primer caso de displasia mesenquimática placentaria en el país con resultado perinatal exitoso. CASO CLÍNICOMujer de 20 años, cesarizada anterior, que ingresa al Hospital Regional de Concepción en enero de 2001 cursando un embarazo de 31 semanas de edad gestacional segura y confiable, complicado por síndrome hipertensivo del embara- INTRODUCCIÓNLa displasia mesenquimática placentaria (DMP) o pseudomola es una rara condición que representa el 0,2% de las referencias a centros especializados por posible enfermedad molar, sin embargo, hay claras evidencias de que es subdiagnosticada (1, 2). En la DMP se observa una difusa degeneración hidrópica macroscópica de las vellosidades en el segundo y tercer trimestre del embarazo, pero sin las alteraciones histológicas de la mola parcial, en que hay hiperplasia focal del trofoblasto y un feto con los severos estigmas de la triploidía. El feto puede ser fenotipicamente normal o mostrar todas o algunas de las características del Sín-drome de Beckwith-Wiedemann (3-6). El diagnós-tico diferencial es con una mola parcial (7, 8) y embarazos múltiples en que coexistían molas completas o parciales con fetos normales (9, 10). Se

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“…34 Finally, mosaicism for androgenetic and biparental cell lines can be confused with PHM both on histologic evaluation and on microsatellite genotyping. 35,36 Our 1 case of mosaicism for androgenetic and biparental cell lines illustrates the need for careful interpretation of quantitative as well as qualitative data obtained from STR genotyping. Despite the aforementioned limitations to the clinical sensitivity and specificity, microsatellite genotyping is valuable because it yields direct information about the mechanism.…”

Section: Commentmentioning

confidence: 98%

Diagnostic Utility of Microsatellite Genotyping for Molar Pregnancy Testing

Furtado

Paxton

Jama

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Molecular genotyping by analysis of DNA microsatellites, also known as short tandem repeats (STRs), is an established method for diagnosing and classifying hydatidiform mole. Distinction of both complete hydatidiform mole and partial hydatidiform mole from nonmolar specimens is relevant for clinical management owing to differences in risk for persistent gestational trophoblastic disease. Objective.—To determine the technical performance of microsatellite genotyping by using a commercially available multiplex assay, and to describe the application of additional methods to confirm other genetic abnormalities detected by the genotyping assay. Design.—Microsatellite genotyping data on 102 cases referred for molar pregnancy testing are presented. A separate panel of mini STR markers, flow cytometry, fluorescence in situ hybridization, and p57 immunohistochemistry were used to characterize cases with other incidental genetic abnormalities. Results.—Forty-eight cases were classified as hydatidiform mole (31, complete hydatidiform mole; 17, partial hydatidiform mole). Genotyping also revealed 11 cases of suspected trisomy and 1 case of androgenetic/biparental mosaicism. Trisomy for selected chromosomes (13, 16, 18, and 21) was confirmed in all cases by using a panel of mini STR markers. Conclusions.—This series illustrates the utility of microsatellite genotyping as a stand-alone method for accurate classification of hydatidiform mole. Other genetic abnormalities may be detected by genotyping; confirmation of the suspected abnormality requires additional testing.

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Placental mesenchymal dysplasia initially diagnosed as partial mole

Cited by 64 publications

References 13 publications

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Displasia Mesenquimática Placentaria

Diagnostic Utility of Microsatellite Genotyping for Molar Pregnancy Testing

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