Placental mesenchymal dysplasia associated with fetal aneuploidy

Cohen, Marta C.; Roper, Emma C.; Sebire, Neil J.; Stanek, Jerzy; Anumba, Dilly

doi:10.1002/pd.1103

Cited by 93 publications

(91 citation statements)

References 22 publications

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“…Another characteristic feature of PMD is aneurismal and varicose dilation of fetal chorionic vessels. Of the 110 cases reviewed, 48 cases of PMD presented data of dilation of fetal chorionic vessels [2,3,9,11,12,13,14,15,17,18,20,21,22,23,24,26,34,35,36,40,41,44,45,46,47,48]. Figure 6 represents the gestational age when aneurismal and varicose dilation of chorionic vessels were identified in the 48 cases and the current case.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 110 cases reviewed, 16 (14.5%) were associated with BWS [2,3,4,5,6,7,8,9,10], 33 (30.0%) had evidence of fetal growth restriction [4,11,12,13,14,15,16,17,18,19,20,21,22,23,24,41,46,48] as in the current case, and 28 (25.5%) ended in intrauterine fetal death [4,6,7,8,12,13,15,16,17,18,25,26,45,47]. There is a female preponderance in cases of PMD; of the infant data reviewed, there were 78 females and 19 males.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 110 cases reviewed, 44 cases of PMD showed multicystic placenta in antenatal ultrasound scan [1,2,3,5,7,9,10,11,12,13,16,18,19,20,22,23,26,27,28,29,30,31,32,33,34,41,42,43,44,45,46,47,48]. Figure 5 represents the gestational age at which the multicystic pattern was identified in the 44 cases and the current case.…”

Section: Resultsmentioning

confidence: 99%

“…All articles without an abstract or with unavailable full text were excluded. We identified 49 articles including 110 cases of PMD [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. …”

Section: Literaturementioning

confidence: 99%

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Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Ohira¹,

Ookubo²,

Tanaka³

et al. 2013

Gynecol Obstet Invest

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Placental mesenchymal dysplasia (PMD) is characterized by multiple hypoechoic vesicles which are similar to molar changes in the placenta; however, the process of such morphological changes of PMD during pregnancy has not been fully understood. We performed a review of all PMD cases published in English and identified 49 articles including 110 cases. With regard to the gestational age at which the multicystic pattern was seen,approximately 70% of cases were diagnosed at 13-20 weeks of gestation. Another characteristic feature of PMD is varicose dilation of fetal chorionic vessels. As many as 90% of cases were diagnosed as placenta with dilated fetal chorionic vessels in the third trimester. We also report a case of PMD which was found at 10 weeks of gestation according to ultrasonic molar patterns. Serial observations of the placenta using ultrasound and magnetic resonance imaging revealed that multicystic lesions became smaller after 23 weeks. In contrast, dilated placental vessels on the fetal side became apparent at 38 weeks. The present review highlights that placental vesicular lesions of PMD may precede dilation of fetal chorionic vessels during pregnancy. It also indicates the potential of a gradual reduction in size of PMD's placental vesicular lesions by serial study of placental images.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Literaturementioning

confidence: 99%

See 2 more Smart Citations

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Ohira¹,

Ookubo²,

Tanaka³

et al. 2013

Gynecol Obstet Invest

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“…Las comunicaciones previas indicaron constitución genética biparental normal (11,14) . Sin embargo, recientemente, Cohen y col. (26) describieron 3 casos con aneuplodías: una trisomía 13 con translocación balanceada entre los cromosomas 1 y 13, un síndrome de Klinefelter (47,XXY) y una triplodia (69,XXX; un caso previamente informado por Paradinas y col. (16) ). Es posible que estas raras aneuploidias sean coincidencias.…”

Section: Discussionunclassified

Displasia mesenquimal placentaria

et al. 2013

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ResumenLa displasia mesenquimal placentaria es una rara condición de placentomegalia y vellosidades coriales anormales, con frecuencia confundida clínicamente como mola hidatidiforme parcial. Sin embargo, es clínica y patológicamente distinta, con alta incidencia de restricción de crecimiento intrauterino y muerte fetal. Se presenta la evolución clínica de una gestante portadora de una displasia mesenquimal placentaria, el primer caso diagnosticado en el Instituto Nacional Materno Perinatal. Se describe el problema, para sospechar el diagnóstico y el manejo de la gestación. Hubo necesidad de realizar cesárea a las 27 semanas de gestación, obteniéndose una recién nacida mujer de 1 048 gramos, con Ápgar 8 al minuto y 9 a los 5 minutos, líquido amniótico sanguinolento en regular cantidad y placentomegalia. La paciente evolucionó satisfactoriamente y salió de alta al tercer día. En el neonato se confirmó una tumoración abdominal hepática y tuvo que ser intervenido quirúrgicamente, previa ganancia ponderal, determinándose el diagnóstico anatomopatológico de hamartoma mesenquimal de hígado. Palabras clave: Placenta; ultrasonografía; recién nacido; hamartoma; hígado; patología. AbstractPlacental mesenchymal dysplasia is a rare condition of placentomegaly and abnormal chorionic villous, often clinically confused as partial hydatidiform mole. However, it is different clinically and pathologically, with high incidence of intrauterine growth restriction and stillbirth. We present the clinical course of a pregnant woman carrying placental mesenchymal dysplasia, the first case diagnosed at the Maternal Perinatal National Institute, how to suspect diagnosis and gestational care. There was need for caesarean section at 27 weeks gestation, obtaining a 1 048 g newborn girl, with Apgar 8 at the first minute and 9 at the fifth minute, bloody amniotic fluid in regular quantity and placentomegaly. Patient evolved satisfactorily and was discharged on the third hospitalization day. An abdominal liver tumor was confirmed in the newborn and surgical pathology report was liver mesenchymal hamartoma.

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Congenital Anomalies

Varner

Byrne

2011

Stillbirth: Prediction, Prevention and Management

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Placental mesenchymal dysplasia associated with fetal aneuploidy

Cited by 93 publications

References 22 publications

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Placental Mesenchymal Dysplasia: Chronological Observation of Placental Images during Gestation and Review of the Literature

Displasia mesenquimal placentaria

Congenital Anomalies

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