Placental Malaria Induces a Unique Methylation Profile Associated with Fetal Growth Restriction
Nida Ozarslan,
Corina Mong,
John Ategeka
et al.
Abstract:BackgroundFetal growth restriction (FGR) is associated with perinatal death and other adverse birth outcomes, as well as long term complications including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases in adulthood. FGR has been associated with placental epigenetic reprogramming, which may mediate these long term outcomes. Placental malaria (PM) is the leading cause of FGR globally, but the impact on placental epigenetics is unknown. We hypothesized that methylomic prof… Show more
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