Placental magnetic resonance imaging T2* measurements in normal pregnancies and in those complicated by fetal growth restriction

Sinding, Marianne; Peters, David A.; Frøkjær, Jens Brøndum; Christiansen, Ole Bjarne; Petersen, Astrid; Uldbjerg, Niels; Sørensen, Anne

doi:10.1002/uog.14917

Cited by 74 publications

(120 citation statements)

References 26 publications

(31 reference statements)

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“…This strategy is expected to freeze motion or contain the motion effects to a limited number of slices . 2D MRI‐based R2* mapping has been applied in the placenta using breath‐hold acquisitions . Free‐breathing 2D CSE‐MRI in the liver has been demonstrated to enable accurate measurements on proton density fat fraction (PDFF), an imaging biomarker of fat content that can be quantified simultaneously with R2* and B0 field in CSE‐MRI techniques .…”

mentioning

confidence: 99%

Evaluation of a motion‐robust 2D chemical shift‐encoded technique for R2* and field map quantification in ferumoxytol‐enhanced MRI of the placenta in pregnant rhesus macaques

Zhu

Reeder

Johnson

et al. 2019

Magnetic Resonance Imaging

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Background 3D chemical shift‐encoded (CSE)‐MRI techniques enable assessment of ferumoxytol concentration but are unreliable in the presence of motion. Purpose To evaluate a motion‐robust 2D‐sequential CSE‐MRI for R2* and B0 mapping in ferumoxytol‐enhanced MRI of the placenta. Study Type Prospective. Animal Model Pregnant rhesus macaques. Field Strength/Sequence 3.0T/CSE‐MRI. Assessment 2D‐sequential CSE‐MRI was compared with 3D respiratory‐gated CSE‐MRI in placental imaging of 11 anesthetized animals at multiple timepoints before and after ferumoxytol administration, and in ferumoxytol phantoms (0 μg/mL–440 μg/mL). Motion artifacts of CSE‐MRI in 10 pregnant women without ferumoxytol administration were assessed retrospectively by three blinded readers (4‐point Likert scale). The repeatability of CSE‐MRI in seven pregnant women was also prospectively studied. Statistical Tests Placental R2* and boundary B0 field measurements (ΔB0) were compared between 2D‐sequential and 3D respiratory‐gated CSE‐MRI using linear regression and Bland–Altman analysis. Results In phantoms, a slope of 0.94 (r2 = 0.99, concordance correlation coefficient ρ = 0.99), and bias of –4.8 s‐1 (limit of agreement [LOA], –41.4 s‐1, +31.8 s‐1) in R2*, and a slope of 1.07 (r2 = 1.00, ρ = 0.99) and bias of 11.4 Hz (LOA –12.0 Hz, +34.8 Hz) in ΔB0 were obtained in 2D CSE‐MRI compared with 3D CSE‐MRI for reference R2* ≤390 s‐1. In animals, a slope of 0.92 (r2 = 0.97, ρ = 0.98) and bias of –2.2 s‐1 (LOA –55.6 s‐1, +51.3 s‐1) in R2*, and a slope of 1.05 (r2 = 0.95, ρ = 0.97) and bias of 0.4 Hz (LOA –9.0 Hz, +9.7 Hz) in ΔB0 were obtained. In humans, motion‐impaired R2* maps in 3D CSE‐MRI (Reader 1: 1.8 ± 0.6, Reader 2: 1.3 ± 0.7, Reader 3: 1.9 ± 0.6), while 2D CSE‐MRI was motion‐free (Reader 1: 2.9 ± 0.3, Reader 2: 3.0 ± 0, Reader 3: 3.0 ± 0). A mean difference of 0.66 s‐1 and coefficient of repeatability of 9.48 s‐1 for placental R2* were observed in the repeated 2D CSE‐MRI. Data Conclusion 2D‐sequential CSE‐MRI provides accurate R2* and B0 measurements in ferumoxytol‐enhanced placental MRI of animals in the presence of respiratory motion, and motion‐robustness in human placental imaging. Level of Evidence: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:580–592.

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confidence: 99%

Evaluation of a motion‐robust 2D chemical shift‐encoded technique for R2* and field map quantification in ferumoxytol‐enhanced MRI of the placenta in pregnant rhesus macaques

Zhu

Reeder

Johnson

et al. 2019

Magnetic Resonance Imaging

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“…A promising noninvasive alternative for detecting IPD conditions is magnetic resonance imaging (MRI). MRI can be used to characterize oxygenation in the placenta through quantification of the transverse relaxation rate (

{normalR}_{2}^{*} = 1 / {normalT}_{2}^{*}

) .

{normalR}_{2}^{*}

is known to increase due to local field inhomogeneities caused by deoxyhemoglobin, the form of hemoglobin without oxygen.…”

mentioning

confidence: 99%

“…

{normalR}_{2}^{*}

is known to increase due to local field inhomogeneities caused by deoxyhemoglobin, the form of hemoglobin without oxygen. Thus,

{normalR}_{2}^{*}

is higher (or

{normalT}_{2}^{*}

is lower) in hypoxic tissues than in normoxic tissues . Despite the potential of MRI as a diagnostic tool to detect IPD via

{normalR}_{2}^{*}

mapping, there is limited understanding of the range of placental

{normalR}_{2}^{*}

across gestational age (GA), within the structure of the placenta, and among normal and abnormal pregnancies.…”

mentioning

confidence: 99%

“…Previous investigations of

{normalR}_{2}^{*}

{normalT}_{2}^{*}

mapping in the placenta have been performed typically at later GAs from 20–40 weeks using a 2D breath‐hold (BH) Cartesian

{normalR}_{2}^{*}

mapping technique; with only one very recent study including earlier GAs of 16–40 weeks . If IPD is detected at later GA, intervention may not be possible or may have limited effectiveness .…”

mentioning

confidence: 99%

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3D mapping of the placenta during early gestation using free‐breathing multiecho stack‐of‐radial MRI at 3T

Armstrong

Liu

Martin

et al. 2018

Magnetic Resonance Imaging

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“…This technique is based on haemoglobin, which possesses different magnetic properties depending on its deoxygenated/oxygenated state. BOLD MRI thus provides information on tissue oxygenation, which can complement information on tissue perfusion Aimot-Macron et al 2013, Chalouhi et al 2013, Sinding et al 2016.…”

Section: R92mentioning

confidence: 99%

Non-invasive evaluation of placental blood flow: lessons from animal models

Mourier¹,

Tarrade²,

Duan³

et al. 2017

Reproduction

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In human obstetrics, placental vascularisation impairment is frequent as well as linked to severe pathological events (preeclampsia and intrauterine growth restriction), and there is a need for reliable methods allowing non-invasive evaluation of placental blood flow. Uteroplacental vascularisation is complex, and animal models are essential for the technical development and safety assessment of these imaging tools for human clinical use; however, these techniques can also be applied in the veterinary context. This paper reviews how ultrasound-based imaging methods such as 2D and 3D Doppler can provide valuable insight for the exploration of placental blood flow both in humans and animals and how new approaches such as the use of ultrasound contrast agents or ultrafast Doppler may allow to discriminate between maternal (non-pulsatile) and foetal (pulsatile) blood flow in the placenta. Finally, functional magnetic resonance imaging could also be used to evaluate placental blood flow, as indicated by studies in animal models, but its safety in human pregnancy still requires to be confirmed. Reproduction (2017) 153 R85-R96

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Placental magnetic resonance imaging T2* measurements in normal pregnancies and in those complicated by fetal growth restriction

Abstract: Objectives

Cited by 74 publications

References 26 publications

Evaluation of a motion‐robust 2D chemical shift‐encoded technique for R2* and field map quantification in ferumoxytol‐enhanced MRI of the placenta in pregnant rhesus macaques

Evaluation of a motion‐robust 2D chemical shift‐encoded technique for R2* and field map quantification in ferumoxytol‐enhanced MRI of the placenta in pregnant rhesus macaques

3D mapping of the placenta during early gestation using free‐breathing multiecho stack‐of‐radial MRI at 3T

Non-invasive evaluation of placental blood flow: lessons from animal models

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