Placental lipoprotein lipase activity is positively associated with newborn adiposity

Heerwagen, Margaret J. R.; Gumina, Diane L.; Hernandez, Teri L.; Pelt, Rachael E. Van; Kramer, Anita; Janssen, Rachel C.; Jensen, Dalan R.; Powell, Theresa L.; Friedman, Jacob E.; Winn, Virginia D.; Barbour, Linda A.

doi:10.1016/j.placenta.2018.03.001

Cited by 41 publications

(34 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was determined to be associated with GDM 47 . In addition, placental lipoprotein lipase activity was positively correlated with newborn birthweight and percentage fat, and was also found to be related to insulin resistance of their offspring 48 . In line with these studies, the present data showed that ANGPT2 and lipoprotein lipase were higher expressed, whereas GPER1 was lower expressed in the GDM group compared with the NGT group.…”

Section: Discussionsupporting

confidence: 86%

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

Tang

2020

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction Non‐coding ribonucleic acids (ncRNAs) have recently been shown to be involved in various biological processes. However, most of these ncRNAs are of unknown function or without annotation. This study first investigated the whole transcriptome profiles of placentas to identify the potential functions that ncRNAs exerted in gestational diabetes mellitus (GDM). Materials and Methods Six placenta samples from healthy pregnant women (n = 3) and GDM (n = 3) were collected to analyze the whole transcriptome profiles by high‐throughput sequencing. Differentially expressed ncRNAs were further validated by quantitative real‐time polymerase chain reaction on an independent set of normal (n = 20) and GDM (n = 20) placenta samples. Results A total of 2,817 microRNAs (miRNAs), 23,339 long non‐coding RNAs (lncRNAs) and 9,513 circular RNAs (circRNAs) were identified. There were 290 differentially expressed ncRNAs in GDM placentas compared with the placentas of healthy pregnant women. Two miRNAs, 86 lncRNAs and 55 circRNAs were upregulated, while two miRNAs, 86 lncRNAs and 59 circRNAs were downregulated in GDM. The expression of the selected ncRNAs, which were further validated by quantitative real‐time polymerase chain reaction, was consistent with the sequencing results. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the major targets of these ncRNAs were associated with insulin resistance, and abnormal glucose and lipid metabolism. A GDM‐related competing endogenous RNA network suggested the interactions between lncRNAs, circRNAs, messenger RNAs and miRNAs. Conclusions The whole transcriptome profiles significantly differed in GDM placentas compared with the placentas of healthy pregnant women, which might be valuable for detecting novel ncRNAs, and providing new research insights into exploring the pathogenic mechanisms of GDM.

show abstract

Section: Discussionsupporting

confidence: 86%

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

Tang

2020

J of Diabetes Invest

View full text Add to dashboard Cite

show abstract

“…Placental lipid metabolism and transport play a central role in determining fetal FFA availability which is complex. Our group has shown that the activity of placental lipoprotein lipase, which hydrolyzes maternal TG to FFA for fetal-placental availability, is correlated with NB%fat estimated by skinfolds at birth( 15 ). The inconsistency in trials exploring maternal TG and fetal growth may not only be due to absent newborn fat mass measurements, but also due to the influence of maternal diet on TG.…”

Section: Discussionmentioning

confidence: 99%

Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy

Barbour

Farabi

Friedman

et al. 2018

Obesity

Self Cite

View full text Add to dashboard Cite

show abstract

“…Another unexpected twist in our earlier CGM data ( 29 ), during which women with obesity on a controlled diet demonstrated higher 24-h glycemic profiles, was that a single fasting TG measured once at ∼14–16 weeks in pregnancy correlated more strongly with NB %fat by skinfolds than any of the glycemic profiles by CGM. The placenta has lipase activity, and the tireless efforts of another postdoctoral fellow demonstrated that the activity of placental lipoprotein lipase, important in hydrolyzing maternal TGs to FFAs that can be transported across the placenta, is highly correlated with NB %fat by skinfolds at birth ( r = 0.59; P = 0.006) and even more so when corrected for gestational age at delivery ( r = 0.75; P = 0.0001) ( 40 ).…”

Section: The Underappreciated Role Of Maternal Lipids As a Contributomentioning

confidence: 99%

Metabolic Culprits in Obese Pregnancies and Gestational Diabetes Mellitus: Big Babies, Big Twists, Big Picture

Barbour

2019

Diabetes Care

Self Cite

View full text Add to dashboard Cite

Pregnancy has been equated to a "stress test" in which placental hormones and growth factors expose a mother's predisposition toward metabolic disease, unleashing her previously occult insulin resistance (IR), mild b-cell dysfunction, and glucose and lipid surplus due to the formidable forces of pregnancy-induced IR. Although pregnancy-induced IR is intended to assure adequate nutrition to the fetus and placenta, in mothers with obesity, metabolic syndrome, or those who develop gestational diabetes mellitus, this overnutrition to the fetus carries a lifetime risk for increased metabolic disease. Norbert Freinkel, nearly 40 years ago, coined this excess intrauterine nutrient exposure and subsequent offspring developmental risk "fuel-mediated teratogenesis," not limited to only excess maternal glucose. Our attempts to better elucidate the causes and mechanisms behind this double-edged IR of pregnancy, to metabolically characterize the intrauterine environment that results in changes in newborn body composition and later childhood obesity risk, and to examine potential therapeutic approaches that might target maternal metabolism are the focus of this article. Rapidly advancing technologies in genomics, proteomics, and metabolomics offer us innovative approaches to interrogate these metabolic processes in the mother, her microbiome, the placenta, and her offspring that contribute to a phenotype at risk for future metabolic disease. If we are successful in our efforts, the researcher, endocrinologist, obstetrician, and health care provider fortunate enough to care for pregnant women have the unique opportunity to positively impact health outcomes not only in the short term but in the long run, not just in one life but in twodand possibly, for the next generation.

show abstract

Placental lipoprotein lipase activity is positively associated with newborn adiposity

Cited by 41 publications

References 49 publications

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

Whole transcriptome expression profiles in placenta samples from women with gestational diabetes mellitus

Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy

Metabolic Culprits in Obese Pregnancies and Gestational Diabetes Mellitus: Big Babies, Big Twists, Big Picture

Contact Info

Product

Resources

About