Placental Leptin: An Important New Growth Factor in Intrauterine and Neonatal Development?

Hassink, Sandra G.; Lancey, Elizabeth de; Sheslow, David V.; Smith-Kirwin, Susan M.; O'Connor, Darlise; Considine, R. V.; Opentanova, Irina; Dostal, Kerstin; Spear, Michael L.; Leef, Kathleen H; Ash, Melissa; Spitzer, Alan R.; Funanage, Vicky L.

doi:10.1542/peds.100.1.e1

Cited by 277 publications

(217 citation statements)

References 20 publications

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“…Enquanto a leptina proveniente do líquido amniótico reflete o ambiente materno, a leptina do cordão é derivada tanto da placenta como do tecido fetal. Assim, a maioria dos estudos publicados até o momento são unâni-mes ao afirmar que a leptina dosada no sangue materno se correlaciona apenas com a adiposidade maternal [12][13][14] .…”

Section: Resultsunclassified

Leptin as a marker of sexual dimorphism in newborn infants

I.M.C.G.¹,

Geloneze²,

Tambascia³

et al. 2004

J Pediatr (Rio J)

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Fonte financiadora: Fundação de Amparo à Pesquisa do Estado de São Paulo -FAPESP.Artigo submetido em 17.12.03, aceito em 26.04.04. AbstractObjective: To determine cord blood leptin levels in newborns appropriate for gestational age, according to gender, birth weight, birth height and ponderal index.Methods: A cross-sectional study was carried out with 132 term newborns appropriate for gestational age (68 females, 64 males), gestational age between 35-42 weeks. Data were collected through interviews with the mothers at the maternity, anthropometrycal study of the newborns, and cord blood estradiol, testosterone and leptin assays obtained immediately after birth.Results: The levels of leptin were significantly higher in females than in males (8.34±0.65 ng/ml versus 6.06±0.71 ng/ml; p = 0.000). The concentrations of estradiol and testosterone did not differ between males and females. Leptin levels were positively correlated with gestational age (r = 0.394, p < 0.01), birth weight (r = 0.466, p < 0.01), birth length (r = 0.335, p < 0.01) and ponderal index (r = 0.326, p < 0.01).Conclusions: Leptin concentration in the umbilical cord is positively correlated with gestational age, birth weight, birth height, and ponderal index, suggesting its participation in the neonatal growth process. In addition, a gender difference with higher levels of leptin in females neonates was observed, suggesting that the sexual dimorphism in relation to body composition already exists in newborns. ResumoObjetivo: Avaliar os níveis de leptina do cordão umbilical em recém-nascidos adequados para a idade gestacional conforme sexo, peso, comprimento e índice ponderal de nascimento.Método: Estudo tipo transversal, envolvendo 132 recém-nascidos adequados para idade gestacional (68 do sexo feminino, 64 do sexo masculino), com idade gestacional de 35-42 semanas. Os dados foram obtidos mediante entrevista com as mães na maternidade, pelo estudo antropométrico dos recém-nascidos e pela dosagem de leptina, estradiol e testosterona no cordão umbilical por meio da coleta imediata após o parto.Resultados: Os recém-nascidos do sexo feminino apresentaram níveis de leptina significativamente maiores que os do sexo masculino (8,34±0,65 ng/ml versus 6,06±0,71 ng/ml; p = 0,000). Os níveis de estradiol e testosterona não variaram conforme o sexo. A leptina se correlacionou positivamente com idade gestacional (r = 0,394, p < 0,01), peso (r = 0,466, p < 0,01), comprimento (r = 0,335, p < 0,01) e índice ponderal (r = 0,326, p < 0,01) dos recém-nascidos.Conclusões: A leptina do cordão umbilical se correlaciona positivamente com idade gestacional, peso, comprimento e índice ponderal do recém-nascido, sugerindo sua participação no processo de crescimento neonatal. Além disso, os recém-nascidos do sexo feminino têm níveis séricos de leptina maiores que os do sexo masculino, sugerindo que o dimorfismo sexual relacionado à composição corporal já possa existir em recém-nascidos. ARTIGO ORIGINAL IntroduçãoA leptina (palavra grega leptos, que significa magro ) é uma p...

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Section: Resultsunclassified

Leptin as a marker of sexual dimorphism in newborn infants

I.M.C.G.¹,

Geloneze²,

Tambascia³

et al. 2004

J Pediatr (Rio J)

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“…In fact, cord blood leptin levels are elevated in infants of diabetic mothers and in largefor-gestational-age newborns [130]. However, whether increased leptin production is due to increased fetal fat mass [147,148] or others factors could affect adipose tissue in the fetus remain unclear, and further investigations regarding the feto-maternal leptinemia are necessary to clarity this point [149,150].…”

Section: Role Of Leptin In Fetal Developmentmentioning

confidence: 99%

Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

115

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Abstract:Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction.

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“…It has become clear that leptin also plays an important role in reproduction, both during pregnancy and early neonatal life (4). Leptin is produced by adipocytes and also by the placenta (5). It has been shown to act as an afferent satiety signal regulating appetite and weight in humans and rodents (6) by suppressing food intake and increasing energy consumption (2).…”

Section: Leptin and Adiponectinmentioning

confidence: 99%

Leptin and adiponectin in the female life course

Lecke¹,

Morsch²,

Spritzer³

2011

Braz J Med Biol Res

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Adipose tissue secretes a variety of adipokines, including leptin and adiponectin, which are involved in endocrine processes regulating glucose and fatty metabolism, energy expenditure, inflammatory response, immunity, cardiovascular function, and reproduction. The present article describes the fluctuations in circulating leptin and adiponectin as well as their patterns of secretion in women from birth to menopause. During pregnancy, leptin and adiponectin seem to act in an autocrine/paracrine fashion in the placenta and adipose tissue, playing a role in the maternal-fetal interface and contributing to glucose metabolism and fetal development. In newborns, adiponectin levels are two to three times higher than in adults. Full-term newborns have significantly higher leptin and adiponectin levels than preterms, whereas small-for-gestational-age infants have lower levels of these adipokines than adequate-for-gestational-age newborns. However, with weight gain, leptin concentrations increase significantly. Children between 5 and 8 years of age experience an increase in leptin and a decrease in adiponectin regardless of body mass index, with a reversal of the newborn pattern for adiponectin: plasma adiponectin levels at age five are inversely correlated with percentage of body fat. In puberty, leptin plays a role in the regulation of menstrual cycles. In adults, it has been suggested that obese individuals exhibit both leptin resistance and decreased serum adiponectin levels. In conclusion, a progressive increase in adiposity throughout life seems to influence the relationship between leptin and adiponectin in women

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Placental Leptin: An Important New Growth Factor in Intrauterine and Neonatal Development?

Cited by 277 publications

References 20 publications

Leptin as a marker of sexual dimorphism in newborn infants

Leptin as a marker of sexual dimorphism in newborn infants

Role of leptin in female reproduction

Leptin and adiponectin in the female life course

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