Placental Lead and its Interaction with Some Essential Metals among Women from Lucknow, India

Singh, Jyoti; Singh, Vipul K.; Anand, Madhu; Kumar, Pavan; Siddiqui, M.K.J.

doi:10.3126/ajms.v1i2.3199

Cited by 11 publications

(11 citation statements)

References 26 publications

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“…Information on laboratory quality controls differed between the earliest and the more recent papers: Before the year 2000, only 11 studies (26.8%) specified having internal quality controls and 6 studies (14.6%) mentioned external controls. In contrast, all studies published after 2000 except 1 ( Terrones-Saldivar et al 2008 ) reported the use of standardized quality control procedures that generally comprised evaluation of accuracy and precision by analysis of certified reference material, and 2 studies included additional interlaboratory comparisons ( Singh et al 2010 ; Zagrodzki et al 2003 ). Only half of the studies specified the limit of detection (LOD), merely stating the value or including the procedure used to treat values below it.…”

Section: Resultsmentioning

confidence: 99%

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Esteban-Vasallo¹,

Aragonés

Pollán

et al. 2012

Environ Health Perspect

156

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Background: Placental tissue may furnish information on the exposure of both mother and fetus. Mercury (Hg), cadmium (Cd), and lead (Pb) are toxicants of interest in pregnancy because they are associated with alterations in child development.Objectives: The aim of this study was to summarize the available information regarding total Hg, Cd, and Pb levels in human placenta and possible related factors.Methods: We performed a systematic search of PubMed/MEDLINE, EMBASE, Lilacs, OSH, and Web of Science for original papers on total Hg, Cd, or Pb levels in human placenta that were published in English or Spanish (1976–2011). Data on study design, population characteristics, collection and analysis of placenta specimens, and main results were extracted using a standardized form.Results: We found a total of 79 papers (73 different studies). Hg, Cd, and Pb levels were reported in 24, 46, and 46 studies, respectively. Most studies included small convenience samples of healthy pregnant women. Studies were heterogeneous regarding populations selected, processing of specimens, and presentation of results. Hg concentrations > 50 ng/g were found in China (Shanghai), Japan, and the Faroe Islands. Cd levels ranged from 1.2 ng/g to 53 ng/g and were highest in the United States, Japan, and Eastern Europe. Pb showed the greatest variability, with levels ranging from 1.18 ng/g in China (Shanghai) to 500 ng/g in a polluted area of Poland.Conclusion: The use of the placenta as a biomarker to assess heavy metals exposure is not properly developed because of heterogeneity among the studies. International standardized protocols are needed to enhance comparability and increase the usefulness of this promising tissue in biomonitoring studies.

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Section: Resultsmentioning

confidence: 99%

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Esteban-Vasallo¹,

Aragonés

Pollán

et al. 2012

Environ Health Perspect

156

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“…Additionally, a quality check sample was always run with each set of samples for lead analysis to maintain accuracy. 14 Placental level of metals (Pb, Cd, Fe, Zn and Cu) were analysed by ICP-MS (Inductive Coupled Plasma-Mass Spectrophotometer) (Element XR, thermo Fisher Scientific, Germany).…”

Section: Methodsmentioning

confidence: 99%

Toxic and essential metals in placenta and its relation with lipid peroxides/glutathione status in pre-term and full-term deliveries

Singh¹,

Agarwal²,

Anand³

et al. 2015

Asian J Med Sci

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Aims and Objectives: Pre-term birth is worldwide problem, little is known about oxidative stress in placental tissue due to metals exposure of women during pregnancy. To seek correlation between concentration of metals and redox status in placental tissue of women with pre-term delivery and compared with those of women with the full-term delivery.Materials and Methods: A hospital based case–control study was conducted, total 80 pregnant women were selected for this study i.e., 30 females who delivered pre-term babies (gestational age <37 week) serve as study group and 50 females who delivered full term babies (gestational age > 37 week) serve as control group. Concentrations of metals lead (Pb), cadmium (Cd), iron (Fe), zinc (Zn), and (Cu), malondialdehyde (MDA) end product of lipid peroxidation and glutathione (GSH) were measured in placenta of study group and control group. Data were analyzed using Students t- test, chi square and linear regression.Results: In preterm cases level of malondialdehyde (MDA) and metals (Cd and Pb) were significantly higher, while level of GSH and some metals (Fe, Zn and Cu) were significantly lower in pre-term cases when compared to full-term cases. There were significant positive correlations of placental metals (Pb and Cd) with MDA (p<0.05), suggests that metals might have influenced pre-term deliveries.Conclusions: The results showed that elevated level of placental Cd and Pb induced oxidative stress which might implicate in pre-term deliveries and higher concentration of Zn and Cu may be concerned with the defence against oxidative stress in placental tissue of full-term cases.Asian Journal of Medical Sciences Vol.7(1) 2015 34-39

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“…The strong band appearing at 1665 cm -1 is fairly assigned to ν(C=O) stretching of semicarbazone [23]. In the IR spectra of complexes of NBPS this band undergoes negative shift and appears at 1640 cm -1 which is indicative of its coordination to the metal ions through oxygen [24,25]. The medium band appearing at 1630 cm -1 in the IR spectra of free ligand is attributed to ν(C=N) of azomethine group of the ligand [26].…”

Section: Resultsmentioning

confidence: 99%