Placental immune response to apple allergen in allergic mothers

Abelius, Martina Sandberg; Enke, Uta; Varosi, Frauke; Hoyer, Heike; Schleußner, E; Jenmalm, Maria C.; Markert, Udo R.

doi:10.1016/j.jri.2014.05.001

Cited by 6 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study examining the influence of in vitro allergen exposure in human placentae showed a distinct cytokine/chemokine milieu in allergic and nonatopic mothers with increased allergen-induced placental IL-6 and TNF-α production in atopic mothers. This might explain the higher incidence of sensitization in off- spring of allergic mothers [36][37][38] . However, modification of the maternal diet during pregnancy did not influence the development of food allergies in the infant later in life seen in the analysis of multiple interventional studies following children up to 10 years of age [39] .…”

Section: Allergic Sensitizationmentioning

confidence: 99%

Mechanisms of Tolerance Induction

Nowak‐Węgrzyn¹,

Chatchatee²

2017

Ann Nutr Metab

View full text Add to dashboard Cite

Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure. An addendum to the NIAID food allergy guidelines recommends introduction of peanut into the diet of 4- to 6-month-old infants with severe eczema or egg allergy as an effective strategy to prevent peanut allergy. Strategies aimed at restoring the skin barrier are currently explored as an alternative approach of prevention of eczema and allergic sensitization. Manipulation of the diet via supplementation with probiotics and prebiotics to restore the healthy gut microbiota represents another potential pathway to induction of tolerance in the gut. Oral, epicutaneous, and sublingual routes of food immunotherapy are promising and induce desensitization in the majority of the treated subjects with food allergy but are not proven to restore permanent oral tolerance. Rigorous multicenter randomized clinical trials are necessary to elucidate the optimal timing, dose, duration, as well as the preventive and therapeutic effects of these diverse approaches.

show abstract

Section: Allergic Sensitizationmentioning

confidence: 99%

Mechanisms of Tolerance Induction

Nowak‐Węgrzyn¹,

Chatchatee²

2017

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…The fetus is exposed to allergens in utero and can mount an antigen-specific IgE response. Intrauterine allergen exposure is probably very common, especially for dietary allergens, as a large proportion of neonates have positive proliferative responses to allergens such as cow's milk protein (Szepfalusi et al 1997), peanut protein (DesRoches et al 2010Frank et al 1999), ovalbumin (Vance et al 2005;Edelbauer et al 2004;Edelbauer et al 2003;Szepfalusi et al 2006) and apple protein (Abelius et al 2014), indicating their immune system has already been activated by these proteins before. The most commonly postulated pathway for allergen exposure of the fetus is transplacental, probably by IgG/allergen immune complex transfer from the mother to the fetus.…”

Section: In Utero-exposure To Maternal Dietary Allergensmentioning

confidence: 99%

Importance of maternal diet in the training of the infant's immune system during gestation and lactation

Jeurink

Knipping

Wiens

et al. 2018

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

Latest forecasts predict that half of the European population will be allergic within the coming 15 years, with food allergies contributing substantially to the total burden; preventive measures are urgently needed. Unfortunately, all attempted alimentary strategies for primary prevention of allergic diseases through allergen avoidance so far have failed. This also holds true for the prevention of food allergies in breastfed infants by the common practice of excluding certain foods with allergenic potential from the maternal diet. As a preventive measure, therefore, exclusion diets should be discouraged. They can exhaust nursing mothers and negatively impact both their nutritional status as well as their motivation to breastfeed. A prolonged exclusion diet may be indicated solely in cases of doctor-diagnosed food allergy following rigid medical tests (e.g. double-blind placebo-controlled food challenges). Indicated cases usually involve exclusion of only a few food items. Continued breastfeeding is generally important for many aspects of the infant's health, including the training of the infant's immune responses to foreign compounds and avoidance of overshooting inflammatory responses. Recent studies suggest that the presence of maternal dietary proteins in amniotic fluid, cord blood, and human milk might support the induction of tolerance towards solid foods in infants. These are exactly the same species of proteins or remnants thereof that, in comparatively few cases, trigger allergic responses. However, the insight that the proteins of maternal dietary origin in human milk are more likely to be cure (or, more precise, directing prevention) than curse has still largely evaded the attention of health care professionals consulted by worried breastfeeding mothers. In this paper, we summarize recent literature on the importance of exposure to dietary proteins in the establishment of immunological tolerance and hence prevention of allergic disease. Multiple organizations have used the scientific knowledge to build (local) guidelines (e.g. AAAAI, EAACI, BSACI) that can support health care professionals to provide the best strategy to prevent the onset of allergic diseases. We thus hope to clarify existing confusion about the allergenic propensities of dietary proteins during early life, which has contributed to exaggerated fears around the diet of pregnant and breastfeeding mothers.

show abstract