Placental hypoplasia and maternal organic vascular disorder in pregnant women with gestational hypertension and preeclampsia

Owaki, Yuki; Watanabe, Kazushi; Iwasaki, Ai; Saitou, Takuya; Matsushita, Hiroshi; Wakatsuki, Akihiko

doi:10.1080/14767058.2019.1608175

Cited by 13 publications

(17 citation statements)

References 17 publications

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“…8-OHdG is also an important oxidative stress biomarker. An animal study suggested that 8-OHdG was associated with the hypertension [32], and similar results were also observed in a human study [33]. As it is widely known from previous studies, oxidative stress damage is an important biological process that interferes with blood pressure [34] and impacts the development of hypertension [35], we speculated that REEs potentially do not significantly contribute to the development of hypertension through the oxidation pathway.…”

Section: Discussionsupporting

confidence: 79%

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Pang

Jiang

et al. 2021

IJERPH

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Solid fuel combustion is an important source of the release of rare earth elements (REEs) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs. We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model.

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Section: Discussionsupporting

confidence: 79%

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Pang

Jiang

et al. 2021

IJERPH

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“…The important role of oxidative stress in the pathophysiology of preeclampsia is further supported by a study in which concentrations of maternal oxygen free radical were measured in 52 women with and without preeclampsia. Maternal serum concentrations of oxygen free radicals were significantly increased in the preeclampsia group relative to the normal group (127). Some researchers conclude that oxidative stress appears to be the central component of both placental and endothelial dysfunction, the causative etiology of preeclampsia (128).…”

Section: Current Understanding Of Pre-eclampsiamentioning

confidence: 99%

Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota

et al. 2020

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Understanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have all been studying the moment the embryo interacts with the maternal endometrium. A perfect relationship between the uterus and the embryo, mediated by a tightly controlled interaction between the embryo and the endometrium, is required for successful implantation. Any factors affecting this communication, such as altered microbiome may lead to poor reproductive outcomes. Current theories suggest that altered microbiota may trigger an inflammatory response in the endometrium that affects the success of embryo implantation, as inflammatory mediators are tightly regulated during the adhesion of the blastocyst to the epithelial endometrial wall. In this review, we will highlight the various microbiome found during the periconceptual period, the microbiomes interaction with immunological responses surrounding the time of implantation, its effect on implantation, placentation and ultimately maternal and neonatal outcomes.

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“…9 GH has a stronger tendency toward inherent organic vascular disorder during pregnancy than PE. 8 Moreover, GH develops differently from PE, with a hyperdynamic circulation and angiogenic biomarker profile that is similar to those in normotensive pregnancy. 10 Compared to those with PE, patients with GH have a lower level of placental hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Association between placental implantation abnormalities and hypertensive disorders of pregnancy

Zheng

Chen

et al. 2021

J of Obstet and Gynaecol

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Aim This study aimed to investigate the association between placental implantation abnormalities (PIAs) and gestational hypertension‐preeclampsia (GH‐PE) in pregnant women. Methods Patients were recruited from 2010 to 2019 into this retrospective study at the International Peace Maternity & Child Health Hospital. PIAs were classified as follows: placenta previa (PP), low‐lying placenta (LP), placenta accreta, and placenta adherence (PA). Logistic regression models were constructed to analyze the associations between placental abnormalities and GH‐PE. Propensity score matching (PSM) was conducted to reduce confounders. The relationship between PP with placenta accreta spectrum (PAS) and GH‐PE were assessed. Results In total, 5527 women were recruited, and 2614 women had an abnormal placenta (992 with LP; 749 with PP 839 and PA; and 34 with placenta accreta). There were 296 patients with GH‐PE in those groups. After adjustments for confounding factors, women with PP had a lower risk of PE (odds ratio [OR]: 0.43; 95% confidence interval [CI]: 0.19–0.86, p = 0.025) than those in the control group. Women with PA had a higher risk of GH‐PE (OR: 1.45; 95% CI: 1.05–1.99, p = 0.022). In addition, we categorized PP into marginal, complete, and partial PP and investigated these associations. We found a lower risk of PE in complete PP (OR: 0.09, 95% CI: 0.01–0.44, p = 0.020) than in marginal or partial PP. There was no significant difference regarding GH‐PE in the PP with PAS group (OR = 0.67, 95% CI: 0.82–2.34, p = 0.525). Conclusion PP, especially complete PP, is associated with a lower risk of PE. PA is associated with higher risks of GH‐PE.

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Placental hypoplasia and maternal organic vascular disorder in pregnant women with gestational hypertension and preeclampsia

Cited by 13 publications

References 17 publications

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota

Association between placental implantation abnormalities and hypertensive disorders of pregnancy

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