Placental Hypertrophy in Severe Pregnancy Anaemia*

Beischer, Norman A.; Sivasamboo, R.; Vohra, S.; Silpisornkosal, Suporn; Reid, Sharon J.

doi:10.1111/j.1471-0528.1970.tb03541.x

Cited by 138 publications

(55 citation statements)

References 13 publications

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“…In human pregnancies, an increased placental ratio is associated with maternal anemia [5,21,22], smoking [5,23], and gestational diabetes mellitus [14], factors that are related to the supply of nutrients. In rats given a calorically balanced diet, a reduction in protein intake from 18 to 9% was associated with an increase in the placental ratio [24].…”

Section: Discussionmentioning

confidence: 99%

Implications of a High Placental Ratio in Pregnancies with Appropriate-for-Gestational Age Neonates

Lao

Wong²

2001

Gynecol Obstet Invest

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Objective: To determine the relationship between the placental weight to birth weight ratio (placental ratio) with maternal pre-pregnancy weight, gestational weight gain, and neonatal outcome in non-diabetic pregnancies resulting in appropriate-for-gestational age (AGA) infants. Methods: A retrospective study was performed on 593 patients with singleton pregnancies, normal results in the 75-gram oral glucose tolerance test and who delivered AGA newborns within a 1-year period. The patients were categorized into high placental ratio (> mean +1 SD based on previous data, n = 113 or 19.1%) and normal ratio groups for the comparison of maternal and neonatal anthropometric parameters. Results: The high placental ratio group had a higher pre-pregnancy weight, body mass index, placental weight, and incidence of low Apgar score, but decreased absolute and percentage gestational weight gain, gestational age, and birth weight. After controlling for pre-pregnancy weight and gestational age, only the correlation between placental weight and percent weight gain remained significant. Conclusion: Our finding suggests that a high placental ratio can identify AGA newborns who are disproportionately small relative to maternal size, and may reflect some form of fetal growth impairment.

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Section: Discussionmentioning

confidence: 99%

Implications of a High Placental Ratio in Pregnancies with Appropriate-for-Gestational Age Neonates

Lao

Wong²

2001

Gynecol Obstet Invest

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“…Mongia et al 8 in his study observed that decreased placental weight in low haemoglobin concentration, similar to the present study. But Beischer et al 9 and Lao et al 10 in their study observed that the maternal anaemia was associated with placental hypertrophy.…”

Section: Discussionmentioning

confidence: 88%

Histopathological Study of Placenta in Anaemia of Pregnancy in Rural Puducherry

M¹,

Rathna²,

Subramanian³

et al. 2016

jemds

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BACKGROUNDPlacenta is a mirror which reflects the intrauterine status of the foetus. It is a vital organ for maintaining and promoting normal foetal development. It undergoes different changes in weight, volume, structure, shape and function continuously throughout the gestation to support the prenatal life. Anaemia during pregnancy is one of the common and serious haematological disorder which causes changes in the structure of placenta, profound changes on the maternal circulatory system and it has serious effects both on mother and foetus. The examination of placenta in-utero as well as postpartum provides insight into prenatal health of baby and mother.

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“…This is shown by re duced birth weights in women with anemia [1,2], living at high altitudes [3], and with raised carboxyhemoglobin levels through cigarette smoking [2,4]. Similar growth re tardation can be induced in animals through exposure to carbon monoxide (CO) [5] or low partial pressures of oxygen [6,7], and through maternal hemorrhage early in preg nancy [8].…”

Section: Introductionmentioning

confidence: 99%

“…Similar growth re tardation can be induced in animals through exposure to carbon monoxide (CO) [5] or low partial pressures of oxygen [6,7], and through maternal hemorrhage early in preg nancy [8]. Paradoxically however, despite obvious damage to the fetus, placental growth is frequently enhanced perhaps to compensate for an otherwise reduced oxygen supply to the fetus [1,5,7,8].…”

Section: Introductionmentioning

confidence: 99%

Placental Growth in Rats Exposed to Carbon Monoxide at Selected Stages of Pregnancy

Lynch

Bruce²

1989

Neonatology

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Maternal hypoxemia has been associated with fetal-growth retardation and placental hypertrophy. Here, rats were exposed to carbon monoxide (CO), 100 ppm, at different stages of gestation to determine when during pregnancy placental hypertrophy can be elicited, whether hypertrophy is sustained when the stimulus is removed, and whether placental hypertrophy correlates with maintenance of normal fetal growth. Groups of rats (11–17 per group) were exposed to CO, throughout gestation, or over days 1–16, 4–12, 10–22 and 18–22, to cover significant periods of placental growth. Maternal carboxyhemoglobin levels were estimated to be in the order of 10–14%, but there was no effect on fetal survival. Fetal weights were significantly reduced by 8 and 6% in groups treated over days 1–22 and 10–22 of pregnancy, but not in those where treatment ceased before term, and surprisingly not in the group treated over days 18–22, the stage of maximal fetal growth. Placental weights were significantly increased by 11–13% in all groups in which carbon monoxide exposure was continued to term, but were unaffected in cases where treatment ceased before term. These results show that near term the placenta, when it is thought to normally reach the limit of its functional capacity, can hypertrophy in response to CO, and suggest that this response benefits the fetus presumably by improving oxygen transport.

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Placental Hypertrophy in Severe Pregnancy Anaemia*

Cited by 138 publications

References 13 publications

Implications of a High Placental Ratio in Pregnancies with Appropriate-for-Gestational Age Neonates

Implications of a High Placental Ratio in Pregnancies with Appropriate-for-Gestational Age Neonates

Histopathological Study of Placenta in Anaemia of Pregnancy in Rural Puducherry

Placental Growth in Rats Exposed to Carbon Monoxide at Selected Stages of Pregnancy

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