“…Expression of osteochondrogenic genes in vessels has been observed in in preclinical and clinical studies (Speer et al, 2009 ; Ho and Shanahan, 2016 ; Lindman et al, 2016 ; Mosch et al, 2017 ; Panh et al, 2017 ). Expression of osteochondrogenic genes has also been detected in placenta, including adrenomedullin, alkaline phosphatase, BMPs, osteocalcin, osteopontin, osteoprotegrin, placental growth factor, Slc20a1, and Slc20a2 (Poggi et al, 2001 ; Johnson et al, 2003 ; Lenhart and Caron, 2012 ; Tannetta et al, 2013 ; Chen and Karumanchi, 2015 ; Yang et al, 2015 ; Wallingford et al, 2016b ). The Slc20a2 knockout mouse develops ectopic calcification in cerebral vasculature and placenta, providing genetic context and suggesting that impaired phosphate transport may be a cause of calcification (Wallingford et al, 2016a , b ).…”