Placental findings among newborns with hypoxic ischemic encephalopathy

Bingham, Adrienne; Gündoğan, Füsun; Rand, Katherine; Laptook, Abbot R.

doi:10.1038/s41372-019-0334-9

Cited by 24 publications

(21 citation statements)

References 24 publications

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“…As shown in Table 2 , only one third of neonates with moderate to severe HIE had normal findings on placental examination. More than half of the placentas revealed chronic pathologies, previously associated with increased risk for HIE [ 9 , 11 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of perinatal sentinel events, placental pathology and cerebral MRI in neonates with hypoxic-ischemic encephalopathy receiving therapeutic hypothermia

et al. 2022

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Objective Placental pathology might provide information on the etiology of hypoxic-ischemic encephalopathy (HIE). To evaluate the association of perinatal sentinel events (PSE), placental pathology and cerebral MRI in cooled neonates with moderate/severe HIE. Study design Retrospective analysis of 52 neonates with HIE registered in the Swiss National Asphyxia and Cooling Register 2011–2019. PSE and Non-PSE groups were tested for association with placental pathology. Placental pathology categories were correlated with MRI scores. Results In total, 14/52 neonates (27%) had a PSE, 38 neonates (73%) did not have a PSE. There was no evidence for an association of occurrence of PSE and placental pathologies (p = 0.364). Neonates with high MRI scores tended to have more often chronic pathologies in their placentas than acute pathologies or normal placentas (p = 0.067). Conclusion Independent of the occurrence of PSE, chronic placental pathologies might be associated with more severe brain injury and needs further study.

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Section: Discussionmentioning

confidence: 99%

“…In recent years, different pathologies on placental examination such as insertion anomalies, histologic placental abruption [ 9 ], fetal malperfusion [ 10 , 11 ], chorioamnionitis [ 12 ] and chronic villitis of unknown etiology [ 13 ] were reported in association with HIE.…”

Section: Introductionmentioning

confidence: 99%

Association of perinatal sentinel events, placental pathology and cerebral MRI in neonates with hypoxic-ischemic encephalopathy receiving therapeutic hypothermia

et al. 2022

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Section: Introductionmentioning

confidence: 93%

“…Thus, placenta pathology might be relevant by analysing the aetiology and timing of the encephalopathy and maybe help explain the varying neuroprotective effect of TH on neurodevelopmental outcome [18,19]. The fact that placental abnormalities could be detected more often in neonates with encephalopathy than in a healthy peer group supports this assumption [1,19]. Further, recent investigations [2,8,9] report that neonates with inflammatory changes in placenta histology such as villitis respond worse to TH, in comparison to neonates with HIE after a perinatal sentinel event with an unremarkable placenta.…”

Section: Introductionmentioning

confidence: 99%

Placental findings are not associated with neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy – an 11-year single-center experience

Benz

Bode

Brandt

et al. 2021

Journal of Perinatal Medicine

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Objectives Although neonates with moderate to severe hypoxic ischemic encephalopathy (HIE) receive therapeutic hypothermia (TH), 40–50% die or have significant neurological disability. The aim of this study is to analyse the association of placental pathology and neurodevelopmental outcome in cooled neonates with HIE at 18–24 months of age. Methods Retrospective analysis of prospectively collected data on 120 neonates registered in the Swiss National Asphyxia and Cooling Register born between 2007 and 2017. This descriptive study examines the frequency and range of pathologic findings in placentas of neonates with HIE. Placenta pathology was available of 69/120 neonates, whose results are summarized as placental findings. As neonates with HIE staged Sarnat score 1 (21/69) did not routinely undergo follow-up assessments and of six neonates staged Sarnat Score 2/3 no follow-up assessments were available, 42/48 (88%) neonates remain to assess the association between placental findings and outcome. Results Of the 42/48 (88%) neonates with available follow up 29% (12/42) neonates died. Major placenta abnormalities occurred in 48% (20/42). Major placenta abnormality was neither associated with outcome at 18–24 months of age (OR 1.75 [95% CI 0.50–6.36, p=0.381]), nor with death by 2 years of age (OR 1.96 [95% CI 0.53–7.78, p=0.320]). Conclusions In this study cohort there could not be shown an association between the placenta findings and the neurodevelopmental outcome at 18–24 months of age.

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“…Levels of coexistent sepsis (affecting 5% of infants in our study) and funisitis (affecting 16% of infants in our study) were similar to those in high-income countries (HICs). 3 All infants in our study had continuous vital signs monitoring.…”

Section: Authors' Replymentioning

confidence: 99%