Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses

Özkan, Sebiha; Vural, Bírol; Dalçįk, Cannur; Tas, Adnan; Dalçik, Hakkı

doi:10.1038/jp.2008.27

Cited by 13 publications

(15 citation statements)

References 27 publications

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“…Barrio et al (2009) showed that placental mRNA levels of hPGH exhibited a tendency towards a down-regulation [34]. In a number of studies using in situ hybridization or immunohistochemistry conflicting results showed that the transcription of hPGH and IGF-I was either increased [37][38][39] or decreased [40]. Our results contradict the increased IGFBP-1 placental expression shown by others ( [32,35], Table 4).…”

Section: Discussioncontrasting

confidence: 84%

Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction

Koutsaki

Sifakis

Zaravinos

et al. 2011

Growth Hormone & IGF Research

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Section: Discussioncontrasting

confidence: 84%

Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction

Koutsaki

Sifakis

Zaravinos

et al. 2011

Growth Hormone & IGF Research

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“…Street et al [19] described a slight increase in IGF1 mRNA expression in SGA placentas, whereas Dalçik et al [20] and more recently, Ozkan et al [31] described increased IGF-I immunostaining in SGA compared with AGA placentas. In contrast to the increased placental expression and content of IGF-I, the cord concentrations of IGF-I were lower in SGA compared with AGA newborns, in accordance with previous reports [32,33].…”

Section: Discussionmentioning

confidence: 99%

Expression and Protein Content of IGF-I and IGF-I Receptor in Placentas from Small, Adequate and Large for Gestational Age Newborns

Íñiguez¹,

González²,

Argandoña³

et al. 2010

Horm Res Paediatr

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In humans, a direct relationship between IGF-I cord blood levels and birth weight has been demonstrated. To determine the placental IGF-I, IGF-II and IGF-IR mRNA and protein contents in full-term pregnancies from appropriate for gestational age (AGA), small for gestational age (SGA) and large for gestational age (LGA) newborns, we studied the placentas from 35 AGA, 30 SGA and 28 LGA pregnancies. The IGF-I, IGF-II and IGF-I receptor (IGF-IR) placental mRNA and protein contents were determined in the basal and chorionic plates of the placenta. IGF1 and IGF1R mRNA was higher in SGA compared to AGA and LGA placentas and lower in LGA compared with AGA placentas. In addition, a higher protein content of IGF-I and IGF-IR was observed in SGA compared with AGA and LGA placentas and lower contents in LGA compared with AGA placentas. These results suggest that the higher IGF-I and IGF-IR contents observed in SGA placentas and the lower contents observed in LGA placentas compared with AGA placentas may be influencing human fetal growth.

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“…IUGR may be caused by various fetal, maternal, and placental factors [1-3,5]. Angiogenesis, defined as the development of new vascular structures, is a placental factor playing an important role in the development of IUGR [2-4,6,7].…”

Section: Introductionmentioning

confidence: 99%

Intrauterine growth restriction and placental angiogenesis

et al. 2010

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BackgroundVascular endothelial growth factor (VEGF), basic-fibroblast growth factor (b-FGF), and endothelial nitric oxide synthase (eNOS) are factors that take part in placental angiogenesis. They are highly expressed during embryonic and fetal development, especially in the first trimester. In this study, we aimed to investigate the role of placental angiogenesis in the development of intrauterine growth restriction (IUGR) by comparing the levels of expression of VEGF-A, b-FGF, and eNOS in normal-term pregnancy and IUGR placentas.MethodsThe expression of VEGF-A, b-FGF, and eNOS was studied using the avidin-biotin-peroxidase method in placental tissues diagnosed as normal (n = 55) and IUGR (n = 55). Results were evaluated in a semi-quantitative manner.ResultsThe expression of all the markers was significantly higher (p < 0.001) in cytotrophoblasts, syncytiotrophoblasts, extravillous trophoblasts, vascular smooth muscle cells, chorionic villous stromal cells, and villous vascular endothelial cells of the IUGR placentas when compared with those collected from normal-term pregnancies.ConclusionIncreased expression of VEGF-A, b-FGF, and eNOS may be the result of inadequate uteroplacental perfusion, supporting the proposal that abnormal angiogenesis plays a role in the pathophysiology of IUGR.

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Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses

Cited by 13 publications

References 27 publications

Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction

Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction

Expression and Protein Content of IGF-I and IGF-I Receptor in Placentas from Small, Adequate and Large for Gestational Age Newborns

Intrauterine growth restriction and placental angiogenesis

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