Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight

Meher, Akshaya; Wadhwani, Nisha; Randhir, Karuna; Mehendale, Savita; Wagh, Girija; Joshi, Sadhana

doi:10.1016/j.jacl.2016.02.004

Cited by 22 publications

(11 citation statements)

References 60 publications

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“…In our protocol, we included children up to 18 years of age, but only one observational study investigated the effect of PUFAs on BMI up to 23 years of age (72). In total, 14 eligible observational studies investigated the relationship between blood levels of TFAs or n-3 LCPUFA during pregnancy or from cord blood or placental tissues, in relation to birth weight or weight in childhood (32,33,(72)(73)(74)(75)(76)(77)(78)(79)(80)(81)(82). All the included observational studies are summarized in Table 4.…”

Section: Description Of Studies and Participantsmentioning

confidence: 99%

“…Only one study included more multiparous women than nulliparous (83). Most of the studies included slightly more boys than girls ranging from 50 to 54% (32,(72)(73)(74)(75)(76)(77)(78)(79)(80)(81)(82), and one study included slightly more girls than boys (48.8%) (33).…”

Section: Description Of Studies and Participantsmentioning

confidence: 99%

“…All the observational studies included in this systematic review investigated different kinds of fatty acids (DHA, EPA, and TFAs) and outcomes (weight and BMI). Four of the studies reported fatty acid levels in mg/L or µg/ml (33,77,80,83), other studies presented in relative percentage (%, w/w) to total fatty acid levels (32,72,73,76,78,79,81,82), one reported fatty acid levels in both ways (74,75). Overall, four studies were from the Generation ⊕ ⊕ ⊕• MODERATE a n-3 LCPUFA probably results in an increase in BMI compared to controls groups *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).…”

Section: Description Of Studies and Participantsmentioning

confidence: 99%

“…Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. R Study from the Netherlands (74)(75)(76)(77), three other studies also involved participants from the Netherlands (33,72,79), one study was from the UK (80), one study was from Italy (81), three studies were from Asia (73,78,82), one was from Canada (32), and, lastly, one study was from the USA [(83); Table 4].…”

Section: Description Of Studies and Participantsmentioning

confidence: 99%

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Systematic Literature Review and Meta-Analysis of the Relationship Between Polyunsaturated and Trans Fatty Acids During Pregnancy and Offspring Weight Development

et al. 2021

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Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and trans fatty acids (TFAs) may have an impact on offspring weight development. We conducted a systematic review and meta-analysis according to PRISMA guidelines to evaluate whether levels of these fatty acids during pregnancy influenced offspring weight development. Randomized controlled trials (RCTs) with DHA and/or EPA supplementation or cohort studies, which examined levels of DHA, EPA, or TFAs in maternal or neonatal blood samples and recorded offspring weight, were included. Overall, 27 RCTs and 14 observational studies were identified. The results showed that DHA and/or EPA supplementation doses >650 mg/day resulted in slightly higher birth weight (MD 87.5 g, 95% CI 52.3–122.6, n = 3,831) and combined BMI and BMI z score at 5–10 years (SMD 0.11, 95% CI 0.04–0.18, n = 3,220). These results were rated as moderate quality. Results from the observational studies were generally inconsistent. High TFA levels during pregnancy seemed to be associated with lower birth weight. Finally, this review and meta-analysis supports a relationship between high maternal or neonatal DHA and/or EPA levels and higher offspring birth weight and weight in childhood. More high-quality long-term studies are still needed.

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Section: Description Of Studies and Participantsmentioning

confidence: 99%

Section: Description Of Studies and Participantsmentioning

confidence: 99%

Section: Description Of Studies and Participantsmentioning

confidence: 99%

Section: Description Of Studies and Participantsmentioning

confidence: 99%

See 2 more Smart Citations

Systematic Literature Review and Meta-Analysis of the Relationship Between Polyunsaturated and Trans Fatty Acids During Pregnancy and Offspring Weight Development

et al. 2021

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“…Recently, the associations between PUFAs and several obstetric disorders have been reported. Meher et al reported that placental DHA levels were lower in mothers delivering low birth weight offspring [4]. Assumpção et al showed that erythrocytes from mothers and fetuses with intrauterine growth restriction (IUGR) exhibited lower levels of AA and DHA [5].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells

et al. 2019

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Nimbolide attenuate the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes

2017

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Nimbolide is a bioactive compound found in Azadirachta indica. This work was devised to investigate the potential effects of nimbolide on intracellular lipid deposition and its associated redox modulation in primary hepatocytes (Heps). Lipid accumulation was induced in Heps by supplementing 1 mM oleic acid for 24 h which was marked by significant accumulation of lipids. The results demonstrated that nimbolide can decrease intracellular cholesterol, free fatty acids and triglycerides. Nimbolide may also improve hepatocytes function through its antioxidant effects by inhibiting oxidative DNA damage and lipid peroxidation by curtailing the reactive oxygen species levels. Further it also restore the mitochondrial potential, improving the endogenous antioxidant levels such as GSH and antioxidant enzyme activities. Nimbolide increased (P < 0.05) liver X receptor-α (LXRα), peroxisome proliferator-activated receptor-γ (PPARγ) and sterol regulatory element-binding protein-1c (SREBP1c) gene expression in Heps. The biological significance of nimbolide may involve hypolipidemic effect, lipid peroxidation inhibition, DNA damage inhibition, ROS inhibition, restoring mitochondrial function, increases in GSH and SOD & CAT activities, and direct regulation of LXRα, PPARγ and SREBP1c gene expression. Nimbolide may be used as effective lipid lowering compound and lipid deposition-induced Heps changes.

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Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight

Cited by 22 publications

References 60 publications

Systematic Literature Review and Meta-Analysis of the Relationship Between Polyunsaturated and Trans Fatty Acids During Pregnancy and Offspring Weight Development

Systematic Literature Review and Meta-Analysis of the Relationship Between Polyunsaturated and Trans Fatty Acids During Pregnancy and Offspring Weight Development

Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells

Nimbolide attenuate the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes

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