Placental development and function in women with a history of placenta‐related complications: a systematic review

Reijnders, Igna F.; Mulders, A.; Koster, Maria P. H.

doi:10.1111/aogs.13259

Cited by 27 publications

(19 citation statements)

References 32 publications

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“…uPVV was measured in 3D-PD ultrasound volumes in the subcohort, obtained conform PV, with standardised settings (pulse repetition frequency 0.6 kHz, wall motion filter ‘low 1’, quality ‘high’, gain −8.0) and expressed in cm 3 . The uPVV was measured offline on a VR desktop system, which projects the ultrasound datasets as holograms that can be enlarged and rotated for more precision ( Reijnders et al ., 2018 ). By erasing the volume of the embryonic and myometrial vessels, only the vessels up to the myometrial-placental border remained, thus, the uPVV.…”

Section: Methodsmentioning

confidence: 99%

“…The maternal decidua is supplied with blood from the spiral arteries, which extensively remodel from the first trimester onwards after invasion of the extravillous trophoblast ( Brosens, 2011 ). Deficiencies in remodelling have been associated with severe pregnancy complications, such as miscarriage, foetal growth restriction and preeclampsia ( Steegers et al ., 2010 ; Reijnders et al ., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort

et al. 2021

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STUDY QUESTION Does frozen-thawed or fresh embryo transfer (ET) influence utero-placental (vascular) development, when studied using three-dimensional (3D) ultrasound and virtual reality imaging techniques? SUMMARY ANSWER In the first trimester, placental developmental parameters, that is, placental volume (PV) and utero-placental vascular volume (uPVV), were comparable between pregnancies resulting from frozen-thawed ET, fresh ET and natural conception; and in the second and the third trimester, uterine artery Doppler indices were lower in pregnancies after frozen-thawed ET compared to pregnancies after fresh ET and natural conception. WHAT IS KNOWN ALREADY Pregnancies after frozen-thawed ET are at risk of developing placenta-related pregnancy complications. There is strong evidence that impaired first-trimester spiral artery remodelling is involved in the pathophysiology of these complications. Studies on longitudinal placental development in pregnancies with different modes of conception, that is, after frozen-thawed ET, fresh ET or natural conception, are lacking. STUDY, DESIGN, SIZE, DURATION Women with singleton pregnancies were included before 10 weeks of gestation, between January 2017 and July 2018, as a subcohort of the ongoing Rotterdam Periconception cohort. Results were partially validated in 722 women from the total cohort, which was conducted from November 2010 onwards. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 214 women, of whom 32 conceived after frozen-thawed ET, 56 conceived after fresh ET and 126 conceived naturally, were selected. PV and uPVV measurements were obtained at 7, 9 and 11 weeks of gestation by transvaginal 3D (power Doppler) ultrasound. The uterine artery pulsatility index (UtA-PI) and resistance index (UtA-RI) were measured transvaginally at 7, 9, 11 and 13 weeks and abdominally at 22 and 32 weeks of gestation by pulsed wave Doppler ultrasound. In the validation cohort, the PV was measured in 722 women. Associations between mode of conception and placental development were studied using linear mixed models. MAIN RESULTS AND THE ROLE OF CHANCE First-trimester parameters of placental development, that is, PV, uPVV, UtA-PI and UtA-RI, were comparable between pregnancies after frozen-thawed and fresh ET and naturally conceived pregnancies. In our validation cohort, comparable results were found for PV. However, the second- and third-trimester UtA-PI and UtA-RI in pregnancies after frozen-thawed ET were significantly lower than in pregnancies after fresh ET (βUtA-PI −0.158 (95% CI: −0.268, −0.048), P = 0.005; βUtA-RI −0.052 (95% CI: −0.089, −0.015), P = 0.006). The second- and third-trimester uterine artery indices in pregnancies after fresh ET were comparable to those in pregnancies after natural conception. LIMITATIONS, REASONS FOR CAUTION The main limitation of this study is the lack of power to optimally detect differences in placental development and placenta-related pregnancy outcomes between pregnancies after different modes of conception. Moreover, our population was selected from a tertiary hospital and included a relatively limited number of pregnancies. Therefore, external validity of the results should be confirmed in a larger sample size. WIDER IMPLICATIONS OF THE FINDINGS These findings indicate no significant impact of conception mode on early placental development and a beneficial impact for frozen-thawed ET on the second- and third-trimester Doppler indices. This suggests that frozen-thawed ET may not be as detrimental for placental perfusion as previous research has demonstrated. As the number of clinics applying the ‘freeze-all strategy’ increases, future research should focus on establishing the optimal uterine environment, with regards to hormonal preparation, prior to ET to reduce placental-related pregnancy complications after frozen-thawed ET. STUDY FUNDING/COMPETING INTEREST(S) This research was funded by the Erasmus MC Medical Research Advisor Committee’s ‘Health Care Efficiency Research’ program and the department of Obstetrics and Gynaecology of the Erasmus MC, University Medical Center, Rotterdam, The Netherlands. JSEL reports grants and personal fees from Ferring, personal fees from Titus Healthcare, grants and personal fees from Ansh Labs, grants from NIH, grants from Dutch Heart Association and grants from ZonMW outside the submitted work. None of the other authors have a conflict of interest. TRIAL REGISTRATION NUMBER Registered at the Dutch Trial Register (NTR6684).

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort

et al. 2021

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“…Preterm birth as a potential result of inflammation has been described in previous work [ 39 , 40 ], and was proposed as a potential mechanism for observed associations between phthalate metabolites and increased odds of preterm birth [ 3 , 41 ]. Parabens may additionally impact estrogen and progesterone receptor signaling [ 42 , 43 ], potentially resulting in abnormal placental development contributing to preterm delivery [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

et al. 2021

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Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

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“…The placenta is an appendage of the fetus that has major endocrine and transport functions (10). it serves a key role in the growth and development of the fetus, and can synthesize numerous hormones, cytokines and transporters (11). aquaporin 3 (aQP3) is a subtype of the aQP family, whose functions include solute transport and signal transduction (12).…”

Section: Introductionmentioning

confidence: 99%

Association between levels of aquaporin 3 in the placenta and adiponectin in the umbilical cord blood with gestational diabetes mellitus and pregnancy outcome

Zhang

Wang

et al. 2020

Mol Med Rep

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Pregnant women with gestational diabetes mellitus (GdM) may have adverse pregnancy outcomes, even if their blood glucose level is well-controlled. aquaporin 3 (aQP3) and adiponectin (aPn) serve important roles in fetal growth and development. However, the associations of aQP3 and aPn with GdM and pregnancy outcome are not known. Therefore, the present study was performed to evaluate the expression of aQP3 in the placenta and aPn in the umbilical artery blood, and the association of the two factors with GdM and pregnancy outcome. The patient cohort was divided into two groups: Pregnant women with GdM; and pregnant women with normal glucose tolerance (nGT). The expression levels of aQP3 in the placenta and aPn in the umbilical artery blood were detected. logistic regression was used to analyze the associations of aQP3 and aPn with GdM and pregnancy outcome. The expression levels of aQP3 and aQP3 mrna in the placenta of the GdM group were decreased compared with that of the nGT group, and the difference was statistically significant (P<0.05). The expression of APN in the umbilical artery blood of the GdM group was also decreased compared with that of the nGT group, and the difference was also statistically significant (P<0.05). Multivariate logistic regression analyses indicated that the aQP3 and aPn levels were negatively correlated not only with the risk of developing GDM [AQP3 odds ratio (OR)=5.00 (P<0.01); APN OR=2.98 (P=0.01)], but also with abnormal pregnancy outcome [(aQP3 OR=4.64 (P<0.01); APN OR=5.41 (P<0.01)]. The levels of aQP3 in the placenta and aPn in the umbilical cord blood were associated with GdM, and the risk of GdM was increased in pregnant women with decreased aQP3 and aPn levels. The aQP3 and aPn levels also had an effect on pregnancy outcome. The risk of abnormal pregnancy outcomes, including cesarean section, macrosomia, fetal distress and neonatal asphyxia, was increased in pregnant women with decreased aQP3 and aPn levels.

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Placental development and function in women with a history of placenta‐related complications: a systematic review

Cited by 27 publications

References 32 publications

The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort

The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort

Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

Association between levels of aquaporin 3 in the placenta and adiponectin in the umbilical cord blood with gestational diabetes mellitus and pregnancy outcome

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