Placental and colostral transfer of antibodies reactive with enteropathogenic Escherichia coli intimins α, β, or γ

Altman, Silvia P.N.; Tino-De-Franco, Milene; Carbonare, Cristiane Barros; Palmeira, Patrícia; Carbonare, S B

doi:10.1016/j.jped.2016.12.005

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…We identified EspA, Intimin, and EspB, three extracellular components of the T3SS encoded by LEE (Gaytá n et al, 2016), as major antigens to confer passive immunity in the offspring after maternal immunization. Notably, antibodies reactive to these T3SS components have been detected in serum (Jenkins et al, 2000;Li et al, 2000;Martinez et al, 1999) and milk samples (Manjarrez-Hernandez et al, 2000;Gavilanes-Parra et al, 2013;Altman et al, 2017) of patients infected with EPEC. The observation that maternal vaccination with single LEE-antigens (Intimin, EspA, or EspB) or their combination conferred similar levels of protection in the offspring suggests that antibodies against these antigens might act through a similar mechanism to confer protection.…”

Section: Discussionmentioning

confidence: 99%

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk

Caballero-Flores¹,

Sakamoto²,

Zeng³

et al. 2019

Cell Host & Microbe

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Graphical Abstract Highlights d Maternal immunization confers protection to offspring against C. rodentium infection d Maternal IgG in breast milk, but not IgA or IgM, is required for neonatal protection d Maternal IgG coats the pathogen and increases its engulfment by neutrophils d LEE-specific antibodies are required to confer protection in the offspring Authors In Brief Caballero-Flores et al. demonstrate that maternal immunization with heatinactivated C. rodentium or surface pathogen antigens protects neonatal mice against pathogen oral challenge. Protection was mediated by the delivery of pathogen-specific IgG through breast milk, which coated the pathogen, increased its phagocytosis, and decreased epithelial attachment in the gut.

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Section: Discussionmentioning

confidence: 99%

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk

Caballero-Flores¹,

Sakamoto²,

Zeng³

et al. 2019

Cell Host & Microbe

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show abstract

“…We identified EspA, Intimin and EspB, three extracellular components of the T3SS encoded by LEE (Gaytán et al, 2016), as major antigens to confer passive immunity in the offspring after maternal immunization. Notably, antibodies reactive to these T3SS components have been detected in serum (Jenkins et al, 2000;Li et al, 2000;Martinez et al, 1999) and milk samples (Manjarrez-Hernandez et al, 2000;Gavilanes-Parra et al, 2013;Altman et al, 2017) of patients infected with EPEC. The observation that maternal vaccination with single LEEantigens (Intimin, EspA or EspB) or their combination conferred similar levels of protection in the offspring suggests that antibodies against these antigens might act through a similar mechanism to confer protection.…”

Section: Discussionmentioning

confidence: 99%

Faculty Opinions recommendation of Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk.

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2019

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

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Infants are more susceptible to enteric infections due to immature immune systems and impaired colonization resistance mediated by the microbiota. Maternal antibodies can provide immunity, with maternal vaccination offering a protective strategy. We find that oral infection of adult females with the enteric pathogen Citrobacter rodentium protects dams and offspring against oral challenge. Parenteral immunization of dams with heat-inactivated C. rodentium reduces pathogen loads and mortality in offspring but not mothers. IgG, but not IgA or IgM, transferred through breast milk to the intestinal lumen of suckling offspring coats the pathogen and reduces intestinal colonization. Protective IgG largely recognizes virulence factors encoded within the locus of enterocyte effacement (LEE) pathogenicity island, including the adhesin Intimin and T3SS filament EspA, which are major antigens conferring protection. Thus, pathogen-specific IgG in breast milk induced during maternal infection or immunization protects neonates against infection with an attaching and effacing pathogen.

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Detection of Microbiota from Human Thymus of Myasthenia Gravis

Meng

et al. 2020

Indian J Surg

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Placental and colostral transfer of antibodies reactive with enteropathogenic Escherichia coli intimins α, β, or γ

Abstract: Anti-intimin antibodies are transferred from mothers to newborns through the placenta, and reinforce the protection provided by breastfeeding against diarrheagenic E. coli infections.

Cited by 7 publications

References 28 publications

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk

Faculty Opinions recommendation of Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk.

Detection of Microbiota from Human Thymus of Myasthenia Gravis

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