Placental alpha microglobulin-1 (PartoSure) test for the prediction of preterm birth: a systematic review and meta-analysis

Pirjani, Reihaneh; Moini, Ashraf; Almasi‐Hashiani, Amir; Mojtahedi, Maryam Farid; Vesali, Samira; Hosseini, Ladan; Sepidarkish, Mahdi

doi:10.1080/14767058.2019.1685962

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…As we only included symptomatic women at risk for PTB, we hypothesize that the onset of preterm labor or ripening of the cervix is the critical trigger for the increase of THBS-1 levels. PAMG-1, fFN and pIGFBP-1 are widely proven biomarkers for the prediction of PTB, and POCT assays for the semi-quantitative detection of these biomarkers in CVF are available [24,41,42]. In a recent meta-analysis comparing test characteristics, PAMG-1 was superior to fFN and pIGFBP-1 with corresponding summary ROC and AUCs of 0.96, 0.87 and 0.80 for the endpoint sPTB within 7 days in symptomatic women [24].…”

Section: Discussionmentioning

confidence: 99%

“…PAMG-1, fFN and pIGFBP-1 are widely proven biomarkers for the prediction of PTB, and POCT assays for the semi-quantitative detection of these biomarkers in CVF are available 24 , 41 , 42 . In a recent meta-analysis comparing test characteristics, PAMG-1 was superior to fFN and pIGFBP-1 with corresponding summary ROC and AUCs of 0.96, 0.87 and 0.80 for the endpoint sPTB within 7 days in symptomatic women 24 .…”

Section: Discussionmentioning

confidence: 99%

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Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study

Stubert

Gründler

Gerber

et al. 2021

Geburtshilfe Frauenheilkd

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Introduction Thrombospondin 1, desmoplakin and stratifin are putative biomarkers for the prediction of preterm birth. This study aimed to validate the predictive capability of these biomarkers in patients at risk of preterm birth. Materials and Methods We included 109 women with symptoms of threatened spontaneous preterm birth between weeks 20 0/7 and 31 6/7 of gestation. Inclusion criteria were uterine contractions, cervical length of less than 25 mm, or a personal history of spontaneous preterm birth. Multiple gestations were also included. Samples of cervicovaginal fluid were taken before performing a digital examination and transvaginal ultrasound. Levels of cervicovaginal thrombospondin 1, desmoplakin and stratifin were quantified by enzyme-linked immunosorbent assays. The primary endpoint was spontaneous preterm birth before 34 + 0 weeks of gestation. Results Sixteen women (14.7%) delivered before 34 + 0 weeks. Median levels of thrombospondin 1 were higher in samples where birth occurred before 34 weeks vs. ≥ 34 weeks of gestation (4904 vs. 469 pg/mL, p < 0.001). Receiver operator characteristics analysis resulted in an area under the curve of 0.86 (p < 0.0001). At an optimal cut-off value of 2163 pg/mL, sensitivity, specificity, positive predictive value and negative predictive value were 0.94, 0.77, 0.42 and 0.99, respectively, with an adjusted odds ratio of 32.9 (95% CI: 3.1 – 345, p = 0.004). Multiple gestation, cervical length, and preterm labor had no impact on the results. Survival analysis revealed a predictive period of more than eight weeks. Levels of desmoplakin and stratifin did not differ between groups. Conclusion Thrombospondin 1 allowed long-term risk estimation of spontaneous preterm birth.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study

Stubert

Gründler

Gerber

et al. 2021

Geburtshilfe Frauenheilkd

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“…Unlike other tests used in clinic, it is minimally invasive and does not rely on biomarkers that are only upregulated close to the time of labor (and therefore have a very limited predictive capacity) such as fetal fibronectin, placental alpha macroglobulin-1, or phosphorylated insulin-like growth factor binding protein-1, which are all detected from cervical secretions. [37][38][39][40] This would allow the risk stratification to take place a lot earlier than with currently available screening tools and thus widen the window for outcome-modifying interventions. Although the excellent predictive value of miR150-5p as a standalone biomarker has already been demonstrated, current work is underway to develop a second-generation LFT that can detect at least two different miRs simultaneously, while also including a miR-independent control line.…”

Section: Discussionmentioning

confidence: 99%

Lateral Flow Test (LFT) Detects Cell‐Free MicroRNAs Predictive of Preterm Birth Directly from Human Plasma

Petrou

Latvanen

Seichepine

et al. 2022

Advanced NanoBiomed Research

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Despite extensive research toward the development of point‐of‐care nucleic acid tests (POC NATs) for the detection of microRNAs (miRs) from liquid biopsies, major hurdles remain including the strict requirement for extensive off‐chip sample preprocessing. Herein, a nucleic acid lateral flow test (NALFT) is reported on that enables the direct detection of endogenous miRs from as little as 3 μL of plasma without the requirement for any enzyme‐catalyzed target amplification or complex miR extraction steps. This is achieved through integration of a denaturing hydrogel composite material onto the LFT, allowing for near‐instantaneous on‐chip release of miRs from their carriers (extracellular vesicles or transport proteins) prior to detection. This next‐generation LFT is sensitive enough to detect endogenous concentrations of miR‐150‐5p, a predictive biomarker for preterm birth (PTB) found deregulated in maternal blood from as early as 12th week of pregnancy. Herein, a key step is represented toward a first bedside test for risk‐stratification during pregnancy by predicting true outcome at a very early stage. More generally, the universal and versatile nature of this novel sample preprocessing platform can further improve the robustness of existing NALFTs and facilitate their application at the POC.

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“…The role of IGFBP-1 and PAPP-A2 in the prediction of PTD and other obstetrical complications has been the subject of previous reports. For example, bedside tests detecting IGFBP-1 (or PAMG-1) in the cervicovaginal fluid are available to predict PTD in women presenting with symptoms of spontaneous preterm labor [83][84][85][86][87][88][89]. Moreover, IGFBP-1 (or PAMG-1) in the cervicovaginal fluid has been proposed as a test for ruptured membranes [90][91][92][93][94].…”

Section: Higher Expression Of Igfbp-1 and Papp-a2 Inmentioning

confidence: 99%

Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System

Prasad¹,

Romero²,

Chaiworapongsa³

et al. 2023

Fetal Diagn Ther

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Introduction: Approximately 47% of women with an episode of preterm labor deliver at term; however, their infants are at greater risk of being small for gestational age and for neurodevelopmental disorders. In these cases, a pathologic insult may disrupt the homeostatic responses sustaining pregnancy. We tested the hypothesis of an involvement of components of the insulin-like growth factor (IGF) system. Methods: This is a cross-sectional study in which maternal plasma concentrations of pregnancy-associated plasma protease (PAPP)-A, PAPP-A2, insulin-like growth factor-binding protein 1 (IGFBP-1), and IGFBP-4 were determined in the following groups of women: (1) no episodes of preterm labor, term delivery (controls, n = 100); (2) episode of preterm labor, term delivery (n = 50); (3) episode of preterm labor, preterm delivery (n = 100); (4) pregnant women at term not in labor (n = 61); and (5) pregnant women at term in labor (n = 61). Pairwise differences in maternal plasma concentrations of PAPP-A, PAPP-A2, IGFBP-1, and IGFBP-4 among study groups were assessed by fitting linear models on log-transformed data and included adjustment for relevant covariates. Significance of the group coefficient in the linear models was assessed via t-scores, with p < 0.05 deemed a significant result. Results: Compared to controls, (1) women with an episode of premature labor, regardless of a preterm or a term delivery, had higher mean plasma concentrations of PAPP-A2 and IGFBP-1 (each p < 0.05); (2) women with an episode of premature labor who delivered at term also had a higher mean concentration of PAPP-A (p < 0.05); and (3) acute histologic chorioamnionitis and spontaneous labor at term were not associated with significant changes in these analytes. Conclusion: An episode of preterm labor involves the IGF system, supporting the view that the premature activation of parturition is a pathologic state, even in those women who delivered at term.

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Placental alpha microglobulin-1 (PartoSure) test for the prediction of preterm birth: a systematic review and meta-analysis

Cited by 17 publications

References 25 publications

Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study

Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study

Lateral Flow Test (LFT) Detects Cell‐Free MicroRNAs Predictive of Preterm Birth Directly from Human Plasma

Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System

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