Placental Abnormalities of Congenital Syphilis

Isolated Positive Treponemal Test in Pregnancy and Placental Abnormalities Without Confirmed Syphilis Infection: A Case Report

“…Frank villous abscess formation has been described in ∼10% of cases of congenital syphilis [ 14 , 15 ]. However, histology is neither specific nor highly sensitive for congenital syphilis [ 12 , 16 ].…”

Maternal-fetal interface: The contribution of histopathological analysis, molecular detection and indirect immunofluorescence of Treponema pallidum pallidum in placental tissue and umbilical cord

“…An additional important finding is the pattern of histopathological modifications found in the specimens of the placenta and umbilical cord, given that the presence of Russell's (1974) triad, which is seen as a positive histological expression of congenital syphilis, was positively associated with the detection of this pathogen by the IF and nPCR, thus confirming the congenital infection (Genest et al, 1996;Russell & Altshuler, 1974). The absence of the triad does not exclude the possibility of infection, however, which requires the identification of the treponeme, given that infection was confirmed by IF in 72.7% of the cases that presented only two histological modifications, considered to be suspect cases.…”

Diagnostic et traitement de la syphilis congénitale

“…L'examen du placenta [6] se montre d'une aide précieuse pour mettre en évidence les infections foetales (immaturité des villosités, prolifération endo-et périvasculaire des vaisseaux villositaires).…”