Placental Abnormalities of Congenital Syphilis

Russell, Peter; Altshuler, Geoffrey

doi:10.1001/archpedi.1974.02110270034007

Cited by 64 publications

(11 citation statements)

References 15 publications

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“…L'examen du placenta [6] se montre d'une aide précieuse pour mettre en évidence les infections foetales (immaturité des villosités, prolifération endo-et périvasculaire des vaisseaux villositaires).…”

Section: Discussionunclassified

Diagnostic et traitement de la syphilis congénitale

Bougaenko¹,

Song²,

Maubeuge³

1982

Dermatology

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Section: Discussionunclassified

Diagnostic et traitement de la syphilis congénitale

Bougaenko¹,

Song²,

Maubeuge³

1982

Dermatology

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“…16 Histologically, the main features described are those of proliferative villitis and a relative immaturity of the villi. We too found that affected infants had lower concentrationsof IgG than the unaffected ones, as well as greater maternal/fetal ratios.…”

Section: Discussionmentioning

confidence: 99%

Congenital Syphilis

Bryan

Nicholson

1981

Clin Pediatr (Phila)

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Twenty-three infants who had positive cord blood VDRL test results are described. Fourteen had clinical signs of congenital syphilis. All but one of the affected, and only one of the unaffected infants had high immunoglobulin M (IgM) levels. Several affected infants had low immunoglobulin G (IgG) levels suggesting poor placental transfer. Total protein, albumin and colloid osmotic pressure (COP) levels were generally within the normal range in the whole group, so these are unlikely to be responsible for the neonatal edema found in many of the affected infants.

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“…In subsequent studies the specificity of these changes has been challenged, and it has been contended that similar alterations may be encountered in the placenta in many other circumstances (Montgomery, 1936;Whipple and Dunham, 1938;Benirschke and Driscoll, 1967). Russell and Altshuler (1974) more recently described the morphological abnormalities of the placenta at term in three proven cases of congenital syphilis. These included: relative immaturity of villi; focal (largely decidual) plasma cell infiltrations; and vascular obliteration due to endothelial and perivascular fibroblastic proliferation.…”

Section: Discussionmentioning

confidence: 99%

Congenital syphilis in aborted second trimester fetus: diagnosis by histological study.

Braunstein¹

1978

J Clin Pathol

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SUMMARY A case of congenital syphilis in an aborted fetus in the second trimester of pregnancy was documented by demonstration of spirochaetes in the fetal liver, despite the fact that diagnostic studies had not been performed on the mother. Suspicion was aroused by the gross and microscopic appearance of the placenta, which appeared identical with that described in proven cases of congenital syphilis. Although these changes have been alleged to be non-specific, the rarity with which such well-developed lesions are encountered in placentas in other circumstances dictates the necessity for further study when they are observed.Recently we observed an example of congenital syphilis in which abnormalities in the placenta of a macerated fetus, spontaneously aborted in an emergency room in the second trimester of pregnancy, prompted study of the fetus for spirochaetes. The diagnosis of congenital syphilis was established by the demonstration of countless spirochaetes in the autolysed fetal liver. Case reportA 19-year-old Caucasian woman was admitted to the emergency room with an impending miscarriage. Her past history revealed that the last menstrual period had occurred approximately four and a half months previously with unprotected coitus thereafter. Two days before admission bleeding had occurred, followed the next day by cramping pain. The patient was a transient, allegedly affianced to the father of the fetus, and travelling through the area. A history of promiscuity was not obtained, and the pregnancy was alleged to be her first.Physical examination revealed a pale young woman with numerous 'condylomata acuminata' and much yellowish vaginal discharge. In the vagina the products of conception could be seen bulging from the dilated cervical os. Haemoglobin was 9-6 g/dl, blood type 0, Rh positive, blood sugar 91 mg/dl. No test for syphilis was performed. A spontaneous, apparently complete abortion

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Placental Abnormalities of Congenital Syphilis

Cited by 64 publications

References 15 publications

Diagnostic et traitement de la syphilis congénitale

Diagnostic et traitement de la syphilis congénitale

Congenital Syphilis

Congenital syphilis in aborted second trimester fetus: diagnosis by histological study.

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