Placenta specific 8 gene induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via the TGF-β/Smad pathway

Huang, Mao‐Ling; Zou, You; Yang, Rui; Yang, Jing; Sheng, Jing; Han, Jing; Kong, Yonggang; Tao, Zezhang; Chen, Shi‐Ming

doi:10.1016/j.yexcr.2018.11.021

Cited by 19 publications

(15 citation statements)

References 23 publications

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“…PLAC8 is a cysteine-rich protein highly expressed in giant trophoblasts and spongiotrophoblast layer in placenta [11]. In a recent study, PLAC8 could facilitate the EMT in nasopharyngeal carcinoma [15]. In addition, high expression of PLAC8 in clear cell renal carcinoma was correlated to malignant progression and poor prognosis.…”

Section: Dicussionmentioning

confidence: 99%

Identification of crucial aberrantly methylated and differentially expressed genes related to cervical cancer using an integrated bioinformatics analysis

Liu

Wang

et al. 2020

Bioscience Reports

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Methylation functions in the pathogenesis of cervical cancer. In the present study, we applied an integrated bioinformatics analysis to identify the aberrantly methylated and differentially expressed genes (DEGS), and their related pathways in cervical cancer. Data of gene expression microarrays (GSE9750) and gene methylation microarrays (GSE46306) were gained from Gene Expression Omnibus (GEO) databases. Hub genes were identified by ‘limma’ packages and Venn diagram tool. Functional analysis was conducted by FunRich. Search Tool for the Retrieval of Interacting Genes Database (STRING) was used to analyze protein–protein interaction (PPI) information. Gene Expression Profiling Interactive Analysis (GEPIA), immunohistochemistry staining, and ROC curve analysis were conducted for validation. Gene Set Enrichment Analysis (GSEA) was also performed to identify potential functions.We retrieved two upregulated-hypomethylated oncogenes and eight downregulated-hypermethylated tumor suppressor genes (TSGs) for functional analysis. Hypomethylated and highly expressed genes (Hypo-HGs) were significantly enriched in cell cycle and autophagy, and hypermethylated and lowly expressed genes (Hyper-LGs) in estrogen receptor pathway and Wnt/β-catenin signaling pathway. Estrogen receptor 1 (ESR1), Erythrocyte membrane protein band 4.1 like 3 (EPB41L3), Endothelin receptor B (EDNRB), Inhibitor of DNA binding 4 (ID4) and placenta-specific 8 (PLAC8) were hub genes. Kaplan–Meier method was used to evaluate survival data of each identified gene. Lower expression levels of ESR1 and EPB41L3 were correlated with a shorter survival time. GSEA results showed that ‘cell adhesion molecules’ was the most enriched item. This research inferred the candidate genes and pathways that might be used in the diagnosis, treatment, and prognosis of cervical cancer.

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Section: Dicussionmentioning

confidence: 99%

Identification of crucial aberrantly methylated and differentially expressed genes related to cervical cancer using an integrated bioinformatics analysis

Liu

Wang

et al. 2020

Bioscience Reports

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“…In hepatocellular carcinoma, PLAC8 is a tumor suppressor regulated by miR-185-5p, and it also suppresses cell proliferation [ 30 ]. However, PLAC8 promotes the carcinogenesis and EMT of nasopharyngeal carcinoma cells via the TGF-β/Smad pathway [ 31 ]. PLAC8 positively regulates trophoblast invasion and migration by upregulating the activation of Rac1 and Cdc42 [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change

Mao

Hu²,

Yang

et al. 2021

J Mol Med

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Tamoxifen resistance remains the major obstacle to the estrogen receptor positive breast cancer endocrine therapy. Placenta-specific 8 (PLAC8) has been implicated in epithelial-mesenchymal transition and tumorigenesis. However, the molecular mechanisms underlying PLAC8 function in the context of tamoxifen resistance are unclear. Curcumin has attracted considerable attention in the last decades. It is isolated from Curcuma longa and has beneficial effects in cancer therapy. We studied this property by using MCF-7 and tamoxifen-resistant breast cancer cells (MCF-7/TAM) cell lines. PLAC8 can regulate MCF-7/TAM cell drug sensitivity through the MAPK/ERK pathway and shows the potential effects of curcumin or as a possible druggable target against tamoxifen failure.

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“… 17 , 18 In cancer cells, PLAC8 induced epithelial‐mesenchymal transition, and cell cycle was reported to be regulated by PLAC8 in pancreatic cancer cells. 19 , 20 PLAC8 also plays a role in autophagosome‐lysosome fusion by initiating oncogenic autophagy in pancreatic cancer. 13 In our studies, high PLAC8 expression is correlated with breast cancer resistant to ADM and poor outcome.…”

Section: Discussionmentioning

confidence: 99%

PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer

Chen

Jia

Mao

et al. 2021

J Cellular Molecular Medi

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Placenta specific 8 gene induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via the TGF-β/Smad pathway

Cited by 19 publications

References 23 publications

Identification of crucial aberrantly methylated and differentially expressed genes related to cervical cancer using an integrated bioinformatics analysis

Identification of crucial aberrantly methylated and differentially expressed genes related to cervical cancer using an integrated bioinformatics analysis

Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change

PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer

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