Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis

Zheng, Wenjie; Bian, Saiyan; Qiu, Shi; Bishop, Colin E.; Wan, Meimei; Xu, Nuo; Sun, Xieyin; Sequeira, Russel Clive; Atala, Anthony; Gu, Zhifeng; Zhao, Weixin

doi:10.1186/s41232-023-00297-z

Cited by 6 publications

(1 citation statement)

References 51 publications

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“…analyzed the mechanism of Pd-MSC-EVs affecting liver fibrosis and found that Pd-MSC-EVs may inhibit the activation of hepatic stellate cells (HSC) through the miR-378c/SKP2 pathway. Thus, Pd-MSC-EVs are expected to become effective drug candidates for the treatment of liver fibrosis ( 242 ).…”

Section: Mscs-derived Exosomes (Mscs-exo) In Cancer Therapymentioning

confidence: 99%

Different origin-derived exosomes and their clinical advantages in cancer therapy

Jin,

Zhang,

Zhang

et al. 2024

Front. Immunol.

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Exosomes, as a class of small extracellular vesicles closely related to the biological behavior of various types of tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding cancer diagnosis, the stability of their membrane structure and their wide distribution in body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor diagnosis in the future. For cancer treatment, exosomes, as the “golden communicators” between cells, can be designed to deliver different drugs, aiming to achieve low-toxicity and low-immunogenicity targeted delivery. Signaling pathways related to exosome contents can also be used for safer and more effective immunotherapy against tumors. Exosomes are derived from a wide range of sources, and exhibit different biological characteristics as well as clinical application advantages in different cancer therapies. In this review, we analyzed the main sources of exosomes that have great potential and broad prospects in cancer diagnosis and therapy. Moreover, we compared their therapeutic advantages, providing new ideas for the clinical application of exosomes.

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Section: Mscs-derived Exosomes (Mscs-exo) In Cancer Therapymentioning

confidence: 99%

Different origin-derived exosomes and their clinical advantages in cancer therapy

Jin,

Zhang,

Zhang

et al. 2024

Front. Immunol.

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The potential of flavonoids in hepatic fibrosis: A comprehensive review

Wenbo,

Jianwei,

Hua

et al. 2024

Phytomedicine

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NSC689857, an inhibitor of Skp2, produces antidepressant-like effects in mice

Liu,

Cheng,

et al. 2024

Behavioural Pharmacology

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We have previously reported that two inhibitors of an E3 ligase S-phase kinase-associated protein 2 (Skp2), SMIP004 and C1, have an antidepressant-like effect in non-stressed and chronically stressed mice. This prompted us to ask whether other Skp2 inhibitors could also have an antidepressant effect. Here, we used NSC689857, another Skp2 inhibitor, to investigate this hypothesis. The results showed that administration of NSC689857 (5 mg/kg) produced an antidepressant-like effect in a time-dependent manner in non-stressed male mice, which started 8 days after drug administration. Dose-dependent analysis showed that administration of 5 and 10 mg/kg, but not 1 mg/kg, of NSC689857 produced antidepressant-like effects in both non-stressed male and female mice. Administration of NSC689857 (5 mg/kg) also induced antidepressant-like effects in non-stressed male mice when administered three times within 24 h (24, 5, and 1 h before testing) but not when administered acutely (1 h before testing). In addition, NSC689857 and fluoxetine coadministration produced additive antidepressant-like effects in non-stressed male mice. These effects of NSC689857 were not associated with the changes in locomotor activity. Administration of NSC689857 (5 mg/kg) also attenuated depression-like behaviors in male mice induced by chronic social defeat stress, suggesting therapeutic potential of NSC689857 in depression. Overall, these results suggest that NSC689857 is capable of exerting antidepressant-like effects in both non-stressed and chronically stressed mice.

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Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis

Cited by 6 publications

References 51 publications

Different origin-derived exosomes and their clinical advantages in cancer therapy

Different origin-derived exosomes and their clinical advantages in cancer therapy

The potential of flavonoids in hepatic fibrosis: A comprehensive review

NSC689857, an inhibitor of Skp2, produces antidepressant-like effects in mice

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