Abstract:The Centre for Medical Image Computing (CMIC) at University College London (UCL) hosted a two-day workshop on placenta imaging on April 12 th and 13 th 2018. The workshop consisted of 10 invited talks, 3 contributed talks, a poster session, a public interaction session and a panel discussion about the future direction of placental imaging. With approximately 50 placental researchers in attendance, the workshop was a platform for engineers, clinicians and medical experts in the field to network and exchange ide… Show more
“…This can make it difficult to establish studies with sufficient numbers to fully investigate new imaging techniques and hence make recommendations about clinical practice. Enhanced coordination of studies between centres and the sharing of clinical and technical expertise alongside imaging data are essential when investigating these conditions and will help to establish the most useful imaging technologies for each pathology. This will speed up the pace of future feto‐placental research for conditions that for the ubiquity of pregnancy remain quite rare but have lifelong impact.…”
Objective
Magnetic resonance imaging (MRI) of placental invasion has been part of clinical practice for many years. The possibility of being better able to assess placental vascularization and function using MRI has multiple potential applications. This review summarises up‐to‐date research on placental function using different MRI modalities.
Method
We discuss how combinations of these MRI techniques have much to contribute to fetal conditions amenable for therapy such as singletons at high risk for fetal growth restriction (FGR) and monochorionic twin pregnancies for planning surgery and counselling for selective growth restriction and transfusion conditions.
Results
The whole placenta can easily be visualized on MRI, with a clear boundary against the amniotic fluid, and a less clear placental‐uterine boundary. Contrasts such as diffusion weighted imaging, relaxometry, blood oxygenation level dependent MRI and flow and metabolite measurement by dynamic contrast enhanced MRI, arterial spin labeling, or spectroscopic techniques are contributing to our wider understanding of placental function.
Conclusion
The future of placental MRI is exciting, with the increasing availability of multiple contrasts and new models that will boost the capability of MRI to measure oxygen saturation and placental exchange, enabling examination of placental function in complicated pregnancies.
“…This can make it difficult to establish studies with sufficient numbers to fully investigate new imaging techniques and hence make recommendations about clinical practice. Enhanced coordination of studies between centres and the sharing of clinical and technical expertise alongside imaging data are essential when investigating these conditions and will help to establish the most useful imaging technologies for each pathology. This will speed up the pace of future feto‐placental research for conditions that for the ubiquity of pregnancy remain quite rare but have lifelong impact.…”
Objective
Magnetic resonance imaging (MRI) of placental invasion has been part of clinical practice for many years. The possibility of being better able to assess placental vascularization and function using MRI has multiple potential applications. This review summarises up‐to‐date research on placental function using different MRI modalities.
Method
We discuss how combinations of these MRI techniques have much to contribute to fetal conditions amenable for therapy such as singletons at high risk for fetal growth restriction (FGR) and monochorionic twin pregnancies for planning surgery and counselling for selective growth restriction and transfusion conditions.
Results
The whole placenta can easily be visualized on MRI, with a clear boundary against the amniotic fluid, and a less clear placental‐uterine boundary. Contrasts such as diffusion weighted imaging, relaxometry, blood oxygenation level dependent MRI and flow and metabolite measurement by dynamic contrast enhanced MRI, arterial spin labeling, or spectroscopic techniques are contributing to our wider understanding of placental function.
Conclusion
The future of placental MRI is exciting, with the increasing availability of multiple contrasts and new models that will boost the capability of MRI to measure oxygen saturation and placental exchange, enabling examination of placental function in complicated pregnancies.
“…The placenta plays a major role in the pathogenesis of many pregnancy complications such as preeclampsia (PE), fetal growth restriction (FGR), and pre-term labor. These complications affect up to one-third of all pregnancies and are leading causes of maternal and perinatal mortality and morbidity globally [ 40 , 41 ].…”
Section: Introductionmentioning
confidence: 99%
“…Current research efforts directed towards developing non-invasive and in utero placenta imaging techniques offers the promise of identifying early and sensitive biomarkers of placental health [ 29 , 41 ]. Correlative imaging that acquires, aligns and fuses complementary information using multiple multiscale modalities from the same specimen is particularly important to advance the understanding of placental structure, function and their relationship [42] .…”
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