Placenta-derived adherent cells attenuate hyperalgesia and neuroinflammatory response associated with perineural inflammation in rats

He, Shuyang; Khan, Junad; Gleason, Joseph; Eliav, Eli; Fik-Rymarkiewicz, Ewa; Herzberg, Uri; Albert, Vivian R.; Hariri, Robert

doi:10.1016/j.bbi.2012.10.015

Cited by 18 publications

(21 citation statements)

References 33 publications

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“…[7][8][9]13 In the current study, we explored the angiogenic properties of PDACs. In vitro, PDACs exhibited various activities consistent with angiogenesis, including enhancement of endothelial cell survival under conditions of serum starvation and stimulation of tube formation.…”

Section: Discussionmentioning

confidence: 99%

“…The cells are anchorage dependent in culture and adhere to plastic during expansion in vitro. 7 PDAC-mediated activities have been studied in vitro, in animal models, and in clinical trials and display immunomodulatory, anti-inflammatory, proregenerative, and neuroprotective properties, [7][8][9][10] suggesting that the cells may have potential utility across a variety of disease indications. PDA-002, an intramuscular formulation of PDACs, is in clinical development for the treatment of peripheral arterial disease with diabetic foot ulcer (http:// clinicaltrials.gov/show/NCT01859117).…”

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confidence: 99%

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Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia

Francki¹,

Labazzo²,

He³

et al. 2016

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia

Francki¹,

Labazzo²,

He³

et al. 2016

Journal of Vascular Surgery

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“…Placenta-Derived Adherent Cells (PDAC®) are mesenchymal stromal-like cells isolated from human placental tissue and culture-expanded [13]–[15]. PDAC® display the nominal phenotype CD34−, CD10+, CD200+, and CD105+ [16].…”

Section: Introductionmentioning

confidence: 99%

Human Placenta-Derived Adherent Cell Treatment of Experimental Stroke Promotes Functional Recovery after Stroke in Young Adult and Older Rats

Shehadah

Chen

Pal³

et al. 2014

PLoS ONE

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BackgroundHuman Placenta-Derived Adherent Cells (PDAC®) are a novel mesenchymal-like cell population derived from normal human placental tissue. PDA-001 is a clinical formulation of PDAC® developed for intravenous administration. In this study, we investigated the efficacy of PDA-001 treatment in a rat model of transient middle cerebral artery occlusion (MCAo) in young adult (2–3 month old) and older rats (10–12 months old).MethodsTo evaluate efficacy and determine the optimal number of transplanted cells, young adult Wistar rats were subjected to MCAo and treated 1 day post MCAo with 1×106, 4×106 or 8×106 PDA-001 cells (i.v.), vehicle or cell control. 4×106 or 8×106 PDA-001 cells were also tested in older rats after MCAo. Treatment response was evaluated using a battery of functional outcome tests, consisting of adhesive-removal test, modified Neurological Severity Score (mNSS) and foot-fault test. Young adult rats were sacrificed 56 days after MCAo, older rats were sacrificed 29 days after MCAo, and lesion volumes were measured using H&E. Immunohistochemical stainings for bromodeoxyuridine (BrdU) and von Willebrand Factor (vWF), and synaptophysin were performed.ResultsIn young adult rats, treatment with 4×106 PDA-001 cells significantly improved functional outcome after stroke (p<0.05). In older rats, significant functional improvement was observed with PDA-001 cell therapy in both of the 4×106 and 8×106 treatment groups. Functional benefits in young adult and older rats were associated with significant increases in the number of BrdU immunoreactive endothelial cells, vascular density and perimeter in the ischemic brain, as well as significantly increased synaptophysin expression in the ischemic border zone (p<0.05).ConclusionPDA-001 treatment significantly improved functional outcome after stroke in both young adult and older rats. The neurorestorative effects induced by PDA-001 treatment may be related to increased vascular density and synaptic plasticity.

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“…Furthermore, in the ipsilateral sciatic nerve, significantly less leukocyte infiltration was observed in PDA-001-treated animals. The results suggest that PDA-001 may provide a novel therapeutic approach in the management of inflammatory neuropathic pain and similar conditions [29] .…”

Section: Metastin and Stem Cells From Human Placentamentioning

confidence: 98%

Putative Prophylaxes Updated of Placenta Extract and Aloe vera as Biogenic Stimulants

Yagi

Ataka

2014

Journal of Gastroenterology and Hepatology Research

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Gastroenterology and Hepatology Researchdation, and the possible putative prophylaxes to optimize cognitive decline in older adults with pre-diabetes symptom. Because of the diversities of placental extract and Aloe vera as biogenic stimulants, present review introduced the briefly selected authors' intentions in each topical subject. Specially, the influence of gut microbiota to host is astonishing and highlighting that the consequence of our behaviours affect not only the environment without, but also that within us. Based on geriatric and neurological viewpoint, present review highlights current therapeutic strategies of placenta extract and Aloe vera as the so-called "biogenic stimulants", aimed at producing a biological rejuvenator in placental extract and improving cognitive function via modifying the brain's insulin sensitivity in Aloe vera.

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Placenta-derived adherent cells attenuate hyperalgesia and neuroinflammatory response associated with perineural inflammation in rats

Cited by 18 publications

References 33 publications

Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia

Angiogenic properties of human placenta-derived adherent cells and efficacy in hindlimb ischemia

Human Placenta-Derived Adherent Cell Treatment of Experimental Stroke Promotes Functional Recovery after Stroke in Young Adult and Older Rats

Putative Prophylaxes Updated of Placenta Extract and Aloe vera as Biogenic Stimulants

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