A comparison of tooth positions and soft tissue profiles was made between samples of edentulous patients recently provided with new complete dentures, and dentate subjects. The dentures were marked with lead foil on the most prominent incisor teeth and labial surfaces of the flanges. Lateral skull radiographs were made with the jaws in centric relation. The dentate subjects were recorded with the teeth held in centric occlusion. Discrete soft and hard tissue landmarks were identified and recorded using an interactive on-line computer system, enabling linear and angular measurements to be made. A mathematical comparison was produced employing a series of independent t-tests. Composite computer tracings were also produced. Important differences were found between the two groups, in which the influence of the upper lip length, mandibular resorption, and selected overbite were identified as factors determining artificial tooth position.