Placebo Effect in the Treatment of Acute Cough in Infants and Toddlers

Paul, Ian M.; Beiler, Jessica S.; Vallati, Julie; Duda, Laura; King, Tonya S.

doi:10.1001/jamapediatrics.2014.1609

Cited by 29 publications

(15 citation statements)

References 21 publications

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“…In addition to the common cold, bronchitis, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and asthma can also generate coughing (Trebbia et al 2005 ;Hargreave & Parameswaran 2006 ;Serisier et al 2009 ;Bucca et al 2010 ). Coughing is present in many diseases and is one of the most common reasons that patients seek medical services (Iyer & Lim 2013 ;Paul et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

CFD transient simulation of the cough clearance process using an Eulerian wall film model

Paz

Suárez

Vence

2016

Computer Methods in Biomechanics and Biomedical Engineering

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In this study, a cough cycle is reproduced using a computational methodology. The Eulerian wall film approach is proposed to simulate airway mucus flow during a cough. The reproduced airway domain is based on realistic geometry from the literature and captures the deformation of flexible tissue. To quantify the overall performance of this complex phenomenon, cough efficiency (CE) was calculated, which provided an easily reproducible measurement parameter for the cough clearance process. Moreover, the effect of mucus layer thickness was examined. The relationship between the CE and the mucus viscosity was quantified using reductions from 20 to 80%. Finally, predictions of CE values based on healthy person inputs were compared with values obtained from patients with different respiratory diseases, including chronic obstructive pulmonary disease (COPD) and respiratory muscle weakness (RMW). It was observed that CE was reduced by 50% in patients with COPD compared with that of a healthy person. On average, CE was reduced in patients with RMW to 10% of the average value of a healthy person.

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Section: Introductionmentioning

confidence: 99%

CFD transient simulation of the cough clearance process using an Eulerian wall film model

Paz

Suárez

Vence

2016

Computer Methods in Biomechanics and Biomedical Engineering

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“…Когда я впервые увидел статью о том, что ложка меда на ночь уменьшает кашель ребенка так же (если не лучше), как и противокашлевые средства [1], я понял автора, измученного бесконечными жалобами родителей на кашель у их ребенка. Ведь эти больные занимают до 25% времени приема практикующего педиатра, вынужденного, как испорченная пластинка на патефоне, без конца повторять сентенции о связи кашля с состоянием носоглотки, о разных видах кашля, о нецелесообразности борьбы с кашлем как таковым [2]. Когда я начинал свою врачебную деятельность, еще можно было выписывать кодеин, но уже тогда необходимость его назначения подвергалась сомнению, поэтому использовали в основном микстуры с алтеем или нашатырно-анисовые капли.…”

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Honey for a Cough?

Таточенко¹

2018

Vopr. sovr. pediatr.

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Контактная информация: Таточенко Владимир Кириллович, доктор медицинских наук, профессор, главный научный сотрудник отделения диагностики и восстановительного лечения НИИ педиатрии НМИЦ здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2,

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“…Honey could be effective and safe, though it should be used with caution for children less than one year old, since, because of the immaturity of their intestinal mucosa, they are more susceptible to botulism spores that could be contained in the honey [50]. A trial published in 2014 also showed a significant effect on cough scores of placebo (grape juice) versus a pure ‘wait and see’ approach [51]. …”

Section: Resultsmentioning

confidence: 99%

“…Without red flags or signs of common disease, in children suffering from isolated non-specific cough, it is not recommended and does not seem beneficial to provide empirical anti-asthma [51-53] or anti-reflux treatments [25], or treatment for allergic rhinitis [17]. …”

Section: Resultsmentioning

confidence: 99%

Prolonged Cough in Pediatric Population First Line Care, Belgian Guidelines

Leconte¹,

Valentin²,

Dromelet³

et al. 2017

TORMJ

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Background:The clinical approach to a prolonged cough, i.e. a cough lasting more than three weeks, is challenging for general practitioners as well for primary care pediatricians. What the recommended clinical approach in primary care is, how cough duration or cough characteristics impact the diagnosis, and what the efficiency and safety of antibiotics or symptomatic treatments are remain in question for primary care physicians.Objective:The last Belgian guidelines were published in 2006 and needed to be reviewed. Those background questions were used to conduct our guideline updating procedure.Methods:We systematically performed a pyramidal literature search between the periods 2006-2014 in order to write evidence based guidelines. The data of the literature was summarized, discussed by the authors, experts and the Belgian primary care guidelines committee. Recommendations were formulated and scored following the GRADE classification.Results:The consultation history as well as the physical examination should be directed towards searching for warning signs (GRADE 1B) and towards the common etiologies depending on cough duration (GRADE 2C). If the cough lasts for more than eight weeks, chest radiography and spirometry should be considered (GRADE 2C). An antibiotic is recommended for a prolonged wet cough (over eight weeks) if prolonged bacterial bronchitis is suspected (GRADE 1B). In the absence of clinical signs of a specific etiology of a cough, no drug can be recommended (GRADE 1B). For all cases, it is initially suggested to avoid irritants (GRADE 1C) as well as to take into account the concerns of parents and inform them about the natural development of a cough.Conclusions:More research is needed to provide evidence on the clinical pathway on prolonged cough for primary care. Cough duration of more than eight weeks and prolonged wet cough are the most useful cough characteristics. Regarding a specific cough treatment, no medication has proved any effect greater than placebo. Attention to environmental triggers and patient-centered care remain the keystones of interventions

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Placebo Effect in the Treatment of Acute Cough in Infants and Toddlers

Abstract: clinicaltrials.gov Identifier: NCT01721395.

Cited by 29 publications

References 21 publications

CFD transient simulation of the cough clearance process using an Eulerian wall film model

CFD transient simulation of the cough clearance process using an Eulerian wall film model

Honey for a Cough?

Prolonged Cough in Pediatric Population First Line Care, Belgian Guidelines

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