Place Coding in the Human Cochlea

Walia, Amit; Ortmann, Amanda; Lefler, Shannon M.; Holden, Timothy A.; Herzog, Jacques A.; Buchman, Craig A.

doi:10.1101/2023.04.13.23288518

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…In this data set, ECochG amplitude decrements were smallest for electrodes that terminated between the 1000 and 2000 Hz tonotopic place, or approximately 3 mm basal to the expected tonotopic site for 500 Hz. Though this finding is a cross-subject observation, it is generally consistent with the post-operative measurements performed across multiple electrodes for a given individual: the recording electrode with the maximum amplitude tends to be more basal than anticipated from the tonotopic map [49,50]. This result is also consistent with observations that the cochlear microphonic component appears dominated by contributions of the tails of the excitation due to phase cancellations at the peak [34].…”

Section: Intracochlear Location Of the Recording Electrodesupporting

confidence: 88%

Evaluation of Real-Time Intracochlear Electrocochleography for Guiding Cochlear Implant Electrode Array Position

Scheperle,

Etler,

Oleson

et al. 2023

JCM

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This study evaluates intracochlear electrocochleography (ECochG) for real-time monitoring during cochlear implantation. One aim tested whether adjusting the recording electrode site would help differentiate between atraumatic and traumatic ECochG amplitude decrements. A second aim assessed whether associations between ECochG amplitude decrements and post-operative hearing loss were weaker when considering hearing sensitivity at the ECochG stimulus frequency compared to a broader frequency range. Eleven adult cochlear implant recipients who were candidates for electro-acoustic stimulation participated. Single-frequency (500-Hz) ECochG was performed during cochlear implantation; the amplitude of the first harmonic of the difference waveform was considered. Post-operative hearing preservation at 500 Hz ranged from 0 to 94%. The expected relationship between ECochG amplitude decrements and hearing preservation was observed, though the trend was not statistically significant, and predictions were grossly inaccurate for two participants. Associations did not improve when considering alternative recording sites or hearing sensitivity two octaves above the ECochG stimulus frequency. Intracochlear location of a moving recording electrode is a known confound to real-time interpretation of ECochG amplitude fluctuations, which was illustrated by the strength of the correlation with ECochG amplitude decrements. Multiple factors contribute to ECochG amplitude patterns and to hearing preservation; these results highlight the confounding influence of intracochlear recording electrode location on the ECochG.

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Section: Intracochlear Location Of the Recording Electrodesupporting

confidence: 88%

Evaluation of Real-Time Intracochlear Electrocochleography for Guiding Cochlear Implant Electrode Array Position

Scheperle,

Etler,

Oleson

et al. 2023

JCM

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“…For calculation of the tonotopic region, the frequencies along the organ of Corti are visualized via the Greenwood function. A tonotopic shift compared with the Greenwood map may occur under high-intensity stimulation [ 120 ] and due to the otopathology of the CI users [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

ZH-ECochG Bode Plot: A Novel Approach to Visualize Electrocochleographic Data in Cochlear Implant Users

Geys,

Sijgers,

Dobrev

et al. 2024

JCM

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Background: Various representations exist in the literature to visualize electrocochleography (ECochG) recordings along the basilar membrane (BM). This lack of generalization complicates comparisons within and between cochlear implant (CI) users, as well as between publications. This study synthesized the visual representations available in the literature via a systematic review and provides a novel approach to visualize ECochG data in CI users. Methods: A systematic review was conducted within PubMed and EMBASE to evaluate studies investigating ECochG and CI. Figures that visualized ECochG responses were selected and analyzed. A novel visualization of individual ECochG data, the ZH-ECochG Bode plot (ZH = Zurich), was devised, and the recordings from three CI recipients were used to demonstrate and assess the new framework. Results: Within the database search, 74 articles with a total of 115 figures met the inclusion criteria. Analysis revealed various types of representations using different axes; their advantages were incorporated into the novel visualization framework. The ZH-ECochG Bode plot visualizes the amplitude and phase of the ECochG recordings along the different tonotopic regions and angular insertion depths of the recording sites. The graph includes the pre- and postoperative audiograms to enable a comparison of ECochG responses with the audiometric profile, and allows different measurements to be shown in the same graph. Conclusions: The ZH-ECochG Bode plot provides a generalized visual representation of ECochG data, using well-defined axes. This will facilitate the investigation of the complex ECochG potentials generated along the BM and allows for better comparisons of ECochG recordings within and among CI users and publications. The scripts used to construct the ZH-ECochG Bode plot are provided by the authors.

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Place Coding in the Human Cochlea

Cited by 2 publications

References 49 publications

Evaluation of Real-Time Intracochlear Electrocochleography for Guiding Cochlear Implant Electrode Array Position

Evaluation of Real-Time Intracochlear Electrocochleography for Guiding Cochlear Implant Electrode Array Position

ZH-ECochG Bode Plot: A Novel Approach to Visualize Electrocochleographic Data in Cochlear Implant Users

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