Place cells, head direction cells, and the learning of landmark stability

Knierim, James; Kudrimoti, Hemant S.; McNaughton, Bruce L.

doi:10.1523/jneurosci.15-03-01648.1995

Cited by 530 publications

(490 citation statements)

References 30 publications

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“…Clearly, an agent needs to differentiate reliable from unreliable cues. However, whether a cue becomes fundamental to the definition of a situation is likely to depend on factors beyond mere reliability, such as novelty, salience, and other factors (Collett, 1987;Gallistel, 1990;Knierim et al, 1995;Pearce & Bouton, 2001). Cues can also modulate the interpretation of other cues (Domjan, 1998).…”

Section: What Defines a State?mentioning

confidence: 99%

Reconciling reinforcement learning models with behavioral extinction and renewal: Implications for addiction, relapse, and problem gambling.

Redish

Jensen

Johnson

et al. 2007

Psychological Review

321

459

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Because learned associations are quickly renewed following extinction, the extinction process must include processes other than unlearning. However, reinforcement learning models, such as the temporal difference reinforcement learning (TDRL) model, treat extinction as an unlearning of associated value and are thus unable to capture renewal. TDRL models are based on the hypothesis that dopamine carries a reward prediction error signal; these models predict reward by driving that reward error to zero. The authors construct a TDRL model that can accommodate extinction and renewal through two simple processes: (a) a TDRL process that learns the value of situation-action pairs and (b) a situation recognition process that categorizes the observed cues into situations. This model has implications for dysfunctional states, including relapse after addiction and problem gambling.

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Section: What Defines a State?mentioning

confidence: 99%

Reconciling reinforcement learning models with behavioral extinction and renewal: Implications for addiction, relapse, and problem gambling.

Redish

Jensen

Johnson

et al. 2007

Psychological Review

321

459

View full text Add to dashboard Cite

show abstract

“…Vestibular inputs are necessary for path integration [58][59][60][61]. Passive rotation has been shown to modulate the activity of place cells [62,63] while bilateral vestibular inactivation or damage abolished location-specific firing of place cells [64,65]. We suggest here that vestibular stimulation enhanced hippocampal LTP, which may be necessary for the formation of place fields [66][67][68].…”

Section: Vestibular Stimulation Enhances Ltpmentioning

confidence: 83%

Vestibular stimulation enhances hippocampal long-term potentiation via activation of cholinergic septohippocampal cells

Tai

Leung

2012

Behavioural Brain Research

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“…Place cells are considered to have undergone remapping when 1) most of the recorded place fields undergo a substantial shift in both angular and radial dimensions, 2) new place fields appear in locations where they were previously absent, or 3) a previously active place cell becomes quiescent or silent (Bostock et al, 1991;Knierim et al, 1995;Muller, 1996). The finding that several place fields exhibited complete remapping, or an angular shift, upon recovery from vestibular inactivation was surprising, given that cell isolation remained consistent across each experiment (see Fig.…”

Section: Remappingmentioning

confidence: 99%

Hippocampal spatial representations require vestibular input

2002

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The hippocampal formation is essential for forming declarative representations of the relationships among multiple stimuli. The rodent hippocampal formation, including the entorhinal cortex and subicular complex, is critical for spatial memory. Two classes of hippocampal neurons fire in relation to spatial features. Place cells collectively map spatial locations, with each cell firing only when the animal occupies that cell's "place field," a particular subregion of the larger environment. Head direction (HD) cells encode directional heading, with each HD cell firing when the rat's head is oriented in that cell's particular "preferred firing direction." Both landmarks and internal cues (e.g., vestibular, motor efference copy) influence place and HD cell activity. However, as is the case for navigation, landmarks are believed to exert greater influence over place and HD cell activity. Here we show that temporary inactivation of the vestibular system led to the disruption of location-specific firing in hippocampal place cells and direction-specific discharge of postsubicular HD cells, without altering motor function. Place and HD cell activity recovered over a time course similar to that of the restoration of vestibular function. These results indicate that vestibular signals provide an important influence over the expression of hippocampal spatial representations, and may explain the navigational deficits of humans with vestibular dysfunction.

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Place cells, head direction cells, and the learning of landmark stability

Abstract: We thank J. Bliss, L. Church, C. Duffield, and M. Galganski for help with animal training and recording; R. D'Monte for help with histology; and

Cited by 530 publications

References 30 publications

Reconciling reinforcement learning models with behavioral extinction and renewal: Implications for addiction, relapse, and problem gambling.

Reconciling reinforcement learning models with behavioral extinction and renewal: Implications for addiction, relapse, and problem gambling.

Vestibular stimulation enhances hippocampal long-term potentiation via activation of cholinergic septohippocampal cells

Hippocampal spatial representations require vestibular input

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