Pla2g1b Places Worms in Peril

Palma, Mark; El-Naccache, Darine W.; Gause, William C.

doi:10.1016/j.chom.2017.09.015

Cited by 3 publications

(1 citation statement)

References 11 publications

(17 reference statements)

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“…According to Entwistle et al [149], the pancreatic phospholipase A2 encoded by this gene prevents larvae from developing into adult parasites, which is essential for establishing resistance against intestinal helminth in mice. Palma et al [150] also stated that this protein interferes with the development of the parasite larvae into adults, contributing to increased resistance to parasites. PLA2G1B protein was found to be upregulated in resistant mice, and mice with the absence of this gene were unable to expel the parasites.…”

Section: Chromosome 17mentioning

confidence: 99%

Genomic Regions Associated with Resistance to Gastrointestinal Nematode Parasites in Sheep—A Review

Cunha,

Lam,

Mallard

et al. 2024

Genes

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Gastrointestinal nematodes (GINs) can be a major constraint and global challenge to the sheep industry. These nematodes infect the small intestine and abomasum of grazing sheep, causing symptoms such as weight loss, diarrhea, hypoproteinemia, and anemia, which can lead to death. The use of anthelmintics to treat infected animals has led to GIN resistance, and excessive use of these drugs has resulted in residue traced in food and the environment. Resistance to GINs can be measured using multiple traits, including fecal egg count (FEC), Faffa Malan Chart scores, hematocrit, packed cell volume, eosinophilia, immunoglobulin (Ig), and dagginess scores. Genetic variation among animals exists, and understanding these differences can help identify genomic regions associated with resistance to GINs in sheep. Genes playing important roles in the immune system were identified in several studies in this review, such as the CFI and MUC15 genes. Results from several studies showed overlapping quantitative trait loci (QTLs) associated with multiple traits measuring resistance to GINs, mainly FEC. The discovery of genomic regions, positional candidate genes, and QTLs associated with resistance to GINs can help increase and accelerate genetic gains in sheep breeding programs and reveal the genetic basis and biological mechanisms underlying this trait.

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Section: Chromosome 17mentioning

confidence: 99%