PLA stereocomplex-chitosan nanoparticles loaded with tenofovir alafenamide as a long-acting antiretrovirals

B Narayanan, Vedha Hari; Kost, Bartłomiej; Lewandowski, Artur; Durai, Ramya Devi; Wawrzyniak, Paweł; Biela, Tadeusz; Wingenfeld, Rieke; Sabeth Sperber, Hannah; Schwarzer, Roland; Brzeziński, Marek

doi:10.1016/j.apt.2023.104205

Cited by 2 publications

(1 citation statement)

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“…For the release pro le, PLA has been found in previous research to have a sustained release pattern of up to 10 days as a nanocarrier, surpassing release limitations to extend its effectiveness over a longer period. The nanoparticles containing PLA and chitosan also showed evidence of sustained release of the active compound over a 2-week period in medical applications (Narayanan 2023). Furthermore, there is data from experiments where surfactants were added to PLA, and in these cases, it is observed that the complete drug release occurs within a time frame ranging from 6 to 12 days (Mulia 2021).…”

Section: Discussionmentioning

confidence: 98%

Triazoles nanoencapsulation in polylactic acid to reduce phytotoxicity in roots

Beltrán,

Viveros,

Contreras

et al. 2024

Preprint

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The use of effective fungicides, such as propiconazole, a high-efficacy and broad-spectrum systemic fungicide, has been a common commercial strategy to combat fungal diseases. However, their indiscriminate and uncontrolled use provokes phytotoxicity in plant roots. Therefore, the objective of this study is to reduce the root phytotoxicity of triazole fungicides through their nanoencapsulation in biodegradable polylactic acid polymer matrices. Using the emulsion and solvent evaporation encapsulation method, the obtained nanoparticles had a hydrodynamic diameter of approximately 200 to 400 nm, an encapsulation efficiency of around 40%, a smooth surface, and a zeta potential close to -40 mV, having great colloidal stability. Experiments with Arabidopsis thaliana demonstrated that the nanoencapsulation of a fungicide derived from propiconazole reduced its phytotoxicity, increasing the length of the roots over 70% more than when the molecule was applied directly, losing only about 15% of its antifungal activity, as shown by the test performed on Fusarium solani. This suggests that nanoencapsulation with biodegradable polymer matrices acts as a protective mechanism for plant roots, which may have practical applications in crop protection and the promotion of sustainable agriculture. However, further research is needed to evaluate its efficacy under field conditions and its long-term environmental impact.

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Section: Discussionmentioning

confidence: 98%