PLA/PLGA nanoparticles prepared by nano spray drying

Abstract

Background Spray drying is a relatively simple, fast, reproducible and scalable drying technology that is suitable for drying heat-sensitive biopharmaceutical compounds. In view of the rapid progress of nanoencapsulation technologies in the pharmaceutical sector, nano spray drying is used in research to improve the powder formulation and release of active ingredients. The Nano Spray Dryer B-90 of the Swiss company Büchi Labortechnik AG extends the size of the powder particles produced into the nanometer scale with narrow size distributions and high encapsulation efficiency. Area covered This study explains the special nano spray drying technology and discusses the influence of the respective process parameters on the powder properties. Applications of nano spray drying for the formulation and encapsulation of active ingredients in PLA/PLGA biopolymers are investigated and discussed. Optimized process parameters for the application of nano spray drying of similar substances are presented. Expert opinion The analyzed studies show the possibility of producing PLGA particles from approx. 2 μm to below 200 nm by nano spray drying, as well as the encapsulation of various active ingredients in spherical particles and nano-in-nanoparticle composite structures made of PLGA polymers for controlled drug delivery systems. The researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, inflammations, cancer, immune diseases, genetic disorders, the regulation of vasodilatation or the surface coating of medical implants with biocompatible PLGA nanoparticles.

Translating the fabrication of protein-loaded poly(lactic-co-glycolic acid) nanoparticles from bench to scale-independent production using microfluidics

“…Despite the lower polymer recovered observed compared to the high (˜100%) lipid recovery obtained after liposome manufacture using microfluidics showed previously [30], the values are inline with those reported in the literature. Values between 40 and 80% are commonly reported when other techniques such as the double emulsion method (w/o/w), spray-drying or nanoprecipitation have been applied for the manufacture of polymers [31,32]. In terms of particle attributes after purification, measurement of the particle size and size distribution after TFF demonstrated that neither the size of the particles, nor the PDI significantly changed after purification for all three PLGA nanoparticle formulations tested (Fig.…”

The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation

“…Microparticles can be prepared by spray drying technique and have been successfully used for the production of microparticle delivery systems [ 11 , 12 , 13 , 14 , 15 , 16 ]. This technique provides the advantage of converting the drug solution into dry particles with a narrow particle size distribution, and the dry particles can be tailored by changing the spray-drying parameters [ 17 , 18 ].…”

Montelukast Nanocrystals for Transdermal Delivery with Improved Chemical Stability

“…The thermal behaviors of the drug powder or dried nanocrystal formulations were analyzed using differential scanning calorimeter (DSC, Model DSC 50, Shimadzu, Japan) [32,33]. Nanocrystals were collected by dilution, ultra-centrifugation, and subsequent drying processes as described in Section 2.4.3.…”