PLA-based magnetic nanoparticles armed with thermo/pH responsive polymers for combination cancer chemotherapy

Sadr, Samad Hosseini; Davaran, Soodabeh; Salehi, Roya; Ramazani, Ali

doi:10.1016/j.jddst.2018.03.019

Cited by 32 publications

(19 citation statements)

References 56 publications

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“…Nowadays, nanobiomaterials have become popular in drug delivery systems and regenerative medicine [1,2]. These materials are widely applied in cancer therapy [3,4], photodynamic therapy [5] and tissue engineering including cartilage and bone regeneration [6,7].…”

Section: Introductionmentioning

confidence: 99%

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

Alipour

Aghazadeh

Akbarzadeh

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Presently, tissue engineering has been developed as an effective option in the restoration and repair of tissue defects. One of the tissue engineering strategies is to use both biodegradable scaffolds and stimulating factors for enhancing cell responses. In this study, the effect of zeolite was assessed on cell viability, proliferation, osteo/odontogenic differentiation, and mineralization of human dental pulp stem cells (hDPSCs) cultured on poly (e-coprolactone)poly (ethylene glycol)-poly (e-caprolactone) (PCL-PEG-PCL) nanofibers. For this purpose, PCL-PEG-PCL nanofibrous scaffolds incorporated with zeolite were prepared via electrospinning. Both PCL-PEG-PCL and PCL-PEG-PCL/Zeolite nanofibrous scaffolds revealed bead-less constructions with average diameters of 430 nm and 437 nm, respectively. HDPSCs were transferred to PCL-PEG-PCL nanofibrous scaffolds containing zeolite nanoparticles. Cell adhesion and proliferation of hDPSCs and their osteo/odontogenic differentiation on these scaffolds were evaluated using MTT assay, Alizarin red S staining, and qRT-PCR assay. The results revealed that PCL-PEG-PCL/Zeolite nanofibrous scaffolds could support better cell adhesion, proliferation and osteogenic differentiation of hDPSCs and as such is expected to be a promising scaffold for bone tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

Alipour

Aghazadeh

Akbarzadeh

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…According to SEM results, the blank micelles had an average diameter of about 34.5 nm and a spherical-like shape. The DLS reported size is higher compared to what SEM reported, that is probably due to the swelling of micelles by water in DLS test versus the dry condition in SEM analysis [45].…”

Section: Cmc Results Characterization Encapsulation and Loading Efficiency Of Micellesmentioning

confidence: 57%

Co-Delivery of Doxorubicin and Conferone by Novel pH-Responsive β-Cyclodextrin Grafted Micelles Triggers Apoptosis of Metastatic Human Breast Cancer Cells

Rahmani

Rahimi

Iranshahi

et al. 2021

Preprint

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Adjuvant-aided combination chemotherapy is one of the most effective ways of cancer treatment by overcoming the multidrug resistance (MDR) and reducing the side-effects of anticancer drugs. In this study Conferone (Conf) was used as adjuvant in combination with Doxorubicin (Dox) for induction of apoptosis to MDA-MB-231 cells. Herein, the novel biodegradable amphiphilic β-cyclodextrin grafted poly maleate-co-PLGA was synthesized by thiol-ene addition and ring-opening process. Micelles obtained from novel copolymer showed exceptional properties such as small size of around 34.5 nm, CMC of 0.1 μg/mL, and cell internalization of around 100 % at 30 min. These novel engineered micelles were used for combination delivery of doxorubicin-conferone with high encapsulation efficiency of near 100 % for both drugs. Our results show that combination delivery of Dox and Conf to MDA-MB-231 cells had synergistic effects (CI<1). According to cell cycle and Annexin-V apoptosis analysis, Dox-Conf loaded micelle significantly induce tumor cell apoptosis (more than 98 % of cells population showed apoptosis at IC50 = 0.259 μg/mL). RT-PCR and western-blot tests show that Dox-Conf loaded βCD-g-PMA-co-PLGA micelle induced apoptosis via intrinsic pathway. Therefore, the unique design of multi-functional pH-sensitive micelles open a new perspective for the development of nanomedicines for combination chemo-adjuvant therapy against malignant cancer.

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“…Studies showed that PS derivatives such as polystyrenesulfonic acid and maleimide-modified polystyrene could enhance the cellular uptake and exert low cytotoxicity towards healthy cells [93,94]. On the other hand, PLA is a FDA-approved synthetic polymer which possesses bioabsorbable, biodegradable and biocompatible properties [95]. PLA has been used to develop smart polymeric NPs in various forms using different strategies, including bioactive-loaded NPs, bioactive-conjugated NPs, and copolymerization with other polymers to express multi-responsive behaviour [40,95,96].…”

Section: Synthetic Polymersmentioning

confidence: 99%

“…On the other hand, PLA is a FDA-approved synthetic polymer which possesses bioabsorbable, biodegradable and biocompatible properties [95]. PLA has been used to develop smart polymeric NPs in various forms using different strategies, including bioactive-loaded NPs, bioactive-conjugated NPs, and copolymerization with other polymers to express multi-responsive behaviour [40,95,96]. For instance, Dariva and colleagues developed amphiphilic light-sensitive NPs consisting of PEG-PLA copolymers conjugated with 1,2-bis(2-hydroxyethylthio) ethylene.…”

Section: Synthetic Polymersmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

Gels

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With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

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PLA-based magnetic nanoparticles armed with thermo/pH responsive polymers for combination cancer chemotherapy

Cited by 32 publications

References 56 publications

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

Co-Delivery of Doxorubicin and Conferone by Novel pH-Responsive β-Cyclodextrin Grafted Micelles Triggers Apoptosis of Metastatic Human Breast Cancer Cells

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

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