Pl<scp>GF</scp>enhances<scp>TLR</scp>‐dependent inflammatory responses in human mononuclear phagocytes

Newell, Laura F.; Holtan, Shernan G.; Yates, Jane E.; Pereira, Leonardo; Tyner, Jeffrey W.; Burd, Irina; Bagby, Grover C.

doi:10.1111/aji.12709

Cited by 14 publications

(11 citation statements)

References 83 publications

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“…PlGF significantly increases IL-6 and IL-8 secretion, cyclooxygenase-2 (Cox-2) expression, and consequent prostaglandin (PG)-E2 and PG-F2α release, and MMP-9 gene expression and enzyme production. [106,145]. Accordingly, PlGF significantly enhanced the magnitude and duration of TNF-α mRNA and protein production by TLR-7/8-activated monocytes and increased the subsequent production of TNF-α-independent inflammatory cytokines.…”

Section: Multifaceted Role Plgf/vegfr-1/nrp1/nrp2 Signaling In Antmentioning

confidence: 99%

Multifaceted Role of the Placental Growth Factor (PlGF) in the Antitumor Immune Response and Cancer Progression

Albonici

Giganti

Modesti

et al. 2019

IJMS

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The sharing of molecules function that affects both tumor growth and neoangiogenesis with cells of the immune system creates a mutual interplay that impairs the host’s immune response against tumor progression. Increasing evidence shows that tumors are able to create an immunosuppressive microenvironment by recruiting specific immune cells. Moreover, molecules produced by tumor and inflammatory cells in the tumor microenvironment create an immunosuppressive milieu able to inhibit the development of an efficient immune response against cancer cells and thus fostering tumor growth and progression. In addition, the immunoediting could select cancer cells that are less immunogenic or more resistant to lysis. In this review, we summarize recent findings regarding the immunomodulatory effects and cancer progression of the angiogenic growth factor namely placental growth factor (PlGF) and address the biological complex effects of this cytokine. Different pathways of the innate and adaptive immune response in which, directly or indirectly, PlGF is involved in promoting tumor immune escape and metastasis will be described. PlGF is important for building up vascular structures and functions. Although PlGF effects on vascular and tumor growth have been widely summarized, its functions in modulating the immune intra-tumoral microenvironment have been less highlighted. In agreement with PlGF functions, different antitumor strategies can be envisioned.

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Section: Multifaceted Role Plgf/vegfr-1/nrp1/nrp2 Signaling In Antmentioning

confidence: 99%

Multifaceted Role of the Placental Growth Factor (PlGF) in the Antitumor Immune Response and Cancer Progression

Albonici

Giganti

Modesti

et al. 2019

IJMS

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“…PlGF was recently found to enhance the inflammatory response of monocytes upon TLR7/8 activation, TLRs typically activated by single stranded RNA viruses. 25 The low PlGF in RVU may represent a mechanism to hamper excessive inflammation to control ocular damage, which is in agreement with the immune privileged site of the eye. Our study includes measurements of intraocular fluids without simultaneous analyses of cytokines in serum.…”

Section: Discussionmentioning

confidence: 57%

An Intraocular Inflammatory Profile of Rubella Associated Uveitis

Fazil

Berge

Langerak

et al. 2018

Ocular Immunology and Inflammation

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“…It has been supported that there is a close correlation between the dysregulation of IL-6 with moderate and severe BPD in preterm infants with a small gestational age [35]. PlGF overexpression contributes an exaggerated in ammatory state [36]. MiR-214 can inhibit angiogenesis procession by suppressing Quaking and pro-angiogenic growth factor expression [37].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-214 Prevents Pulmonary Angiogenesis and Alveolarization in Rat Models with Bronchopulmonary Dysplasia via PlGF-Dependent STAT3 Signaling Pathway

Zhiqun

Hong

et al. 2020

Preprint

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Background: In recent years, the roles of microRNAs (miRNAs) in pulmonary diseases have been widely studied and researched. However, the molecular mechanism by which miR-214 affects bronchopulmonary dysplasia (BPD) remains elusive and merits further exploration. Hence, this study aims to clarify the function of miR-214 in pulmonary angiogenesis and alveolarization in preterm infants with BPD. Methods: BPD neonatal rat model was induced by hyperoxia, and pulmonary epithelial cells were isolated from rats and exposed to hyperoxia. Gain- or loss-of-function experiments were performed in BPD neonatal rats and hyperoxic pulmonary epithelial cells. MiR-214 and PlGF expression in BPD neonatal rats, and eNOS, Bcl-2, c-myc, Survivin, α-SMA and E-cadherin expression in hyperoxic pulmonary epithelial cells were detected using RT-qPCR and western blot analysis. The interaction between PlGF and miR-214 was identified using dual luciferase reporter gene assay and RIP assay. ELISA was adopted to assess IL-1β, TNF-a, IL-6, ICAM-1 and Flt-1 expression in rats. Results: Decreased miR-214 expression and elevated PlGF expression were evident in the lung tissues of neonatal rats with BPD. PlGF was a target of miR-214, and miR-214 downregulated PlGF to inactivate the STAT3 signaling pathway. miR-214 overexpression or PlGF silencing decreased apoptosis of hyperoxic pulmonary epithelial cells and declined pulmonary angiogenesis and alveolarization in BPD neonatal rats. Conclusions: Collectively, miR-214 can protects against pulmonary angiogenesis and alveolarization in preterm infants with BPD by suppressing PlGF and blocking STAT3 signaling pathway.

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PlGFenhancesTLR‐dependent inflammatory responses in human mononuclear phagocytes

Cited by 14 publications

References 83 publications

Multifaceted Role of the Placental Growth Factor (PlGF) in the Antitumor Immune Response and Cancer Progression

Multifaceted Role of the Placental Growth Factor (PlGF) in the Antitumor Immune Response and Cancer Progression

An Intraocular Inflammatory Profile of Rubella Associated Uveitis

MicroRNA-214 Prevents Pulmonary Angiogenesis and Alveolarization in Rat Models with Bronchopulmonary Dysplasia via PlGF-Dependent STAT3 Signaling Pathway

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