PK/PD Approaches

Yu, Yichao; Rüppel, Diether; Weber, Willi; Derendorf, Hartmut

doi:10.1007/978-3-319-56637-5_26-1

Cited by 3 publications

(4 citation statements)

References 48 publications

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“…Finally, we applied the sigmoid model, which is analogous to the maximum response, or Hill [ 25 , 42 ] to the values of index E vs. EO concentration to understand the mechanics of the relationship between the concentration of these and their bactericidal effects and, thus, be able to obtain more information about the behavior of S. aureus under the different conditions evaluated. Redefining the previous equation: E = E 0 − (E max .…”

Section: Methodsmentioning

confidence: 99%

“…There exist several kinetic models like Gompertz and square root models that can provide the growth rate (μ), lag period duration (LPD), and the maximum population density (MPD) [ 23 ]. There also exist models to describe the survival or the destruction of bacteria over the time, like the sigmoid minus the base model [ 24 ], which is similar to E max models [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Modeling the Growth and Death of Staphylococcus aureus against Melaleuca armillaris Essential Oil at Different pH Conditions

et al. 2021

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Essential oils (EO) are a great antimicrobial resource against bacterial resistance in public health. Math models are useful in describing the growth, survival, and inactivation of microorganisms against antimicrobials. We evaluated the antimicrobial activity of Melaleuca armillaris EO obtained from plants placed in the province of Buenos Aires (Argentina) against Staphylococcus aureus. The minimum inhibitory and bactericidal concentrations were close and decreased, slightly acidifying the medium from pH 7.4 to 6.5 and 5.0. This result was also evidenced by applying a sigmoid model, where the time and EO concentration necessaries to achieve 50% of the maximum effect decreased when the medium was acidified. Moreover, at pH 7.4, applying the Gompertz model, we found that subinhibitory concentrations of EO decreased the growth rate and the maximum population density and increased the latency period concerning the control. Additionally, we established physicochemical parameters for quality control and standardization of M. armillaris EO. Mathematical modeling allowed us to estimate key parameters in the behavior of S. aureus and Melaleuca armillaris EO at different pH. This is interesting in situations where the pH changes are relevant, such as the control of intracellular infections in public health or the development of preservatives for the food industry.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modeling the Growth and Death of Staphylococcus aureus against Melaleuca armillaris Essential Oil at Different pH Conditions

et al. 2021

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“…The E index values vs . ERY concentration data was mathematically modeled using a sigmoid model similar to a maximum response model ( 27 , 37 , 38 ). In this way we could analyzed deeply the effect of EO in the antimicrobial activity of ERY against S. aureus under the different conditions evaluated.…”

Section: Methodsmentioning

confidence: 99%

In vitro synergistic interaction between Melaleuca armillaris essential oil and erythromycin against Staphylococcus aureus isolated from dairy cows

et al. 2022

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Staphylococcus aureus frequently causes subclinical mastitis around the world with a high impact on the milk industry and public health. Essential oils (EO) are recognized antimicrobials that can be synergistic with antibiotics. The main objective of this study was to evaluate the essential oil (EO) of Melaleuca armillaris as an adjuvant of erythromycin (ERY) for the alternative treatment of bovine mastitis caused by S. aureus. The Minimum Inhibitory and Bactericidal Concentrations (MIC and MBC) of EO, ERY, and its combinations were established against S. aureus at different pHs (7.4, 6.5 and 5.0), emulating extra and intracellular conditions. Sensitive (N = 3) and resistant (N = 3) strains to ERY and S. aureus ATCC 29213 as control were used. Math models were applied to describe the antibacterial activity of EO and combinations EO-ERY. The EO was bactericidal against all the strains independently of the pH with a slight improvement in acid conditions. The synergism between EO and ERY was estimated by the Fractional Inhibitory Concentration Index (FIC) and by mathematical modeling of the bacterial killing data. Synergism was observed with ERY, where combinations had bactericidal activity also even with pH modification. M. armillaris EO is an interesting adjuvant for ERY, being a promissory option for further analysis of intracellular efficacy against S. aureus.

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“…The E index values vs. ERY concentration data was mathematically modeled using a sigmoid model similar to a maximum response model [27,53,54]. In this way we could analyzed deeply the effect of EO in the antimicrobial activity of ERY against S. aureus under the different conditions evaluated.…”

Section: Math Modelling Of E Indexmentioning

confidence: 99%

Erythromycin and <em>Melaleuca armillaris</em> Essential Oil Combination against <em>Staphylococcus aureus</em> Isolated from Dairy Cows

Buldain¹,

Castillo²,

Buchamer³

et al. 2022

Preprint

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Staphylococcus aureus frequently causes subclinical mastitis around the world with high impact in milk industry and public health. Essential oils (EO) are recognized antimicrobials that can be synergistic with antibiotics. The main objective of this study was evaluating the essential oil (EO) of Melaleuca armillaris as an adjuvant of erythromycin (ERY) for the alternative treatment of bovine mastitis caused by S. aureus. The Minimum Inhibitory and Bactericidal Concentrations (MIC and MBC) of EO, ERY, and its combinations were established against S. aureus at different pHs (7.4, 6.5 and 5.0), emulating extra and intracellular conditions. Sensible (N=3) and resistant (N=3) strains to ERY and S. aureus ATCC 29213 as control were used. Math models were applied to described the antibacterial activity of EO and combinations EO-ERY. The EO was bactericidal against all the strains independently of the pH with a slightly improvement in acid conditions. The synergism between EO and ERY was estimated by the Fractional Inhibitory Concentration Index (FIC) and by mathematical modeling of the bacterial killing data. Synergism was observed with ERY, where combinations had bactericidal activity also even with pH modification. M. armillaris EO is an interesting adjuvant for ERY, being a promissory option for further analysis of intracellular efficacy against S. aureus.

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PK/PD Approaches

Cited by 3 publications

References 48 publications

Modeling the Growth and Death of Staphylococcus aureus against Melaleuca armillaris Essential Oil at Different pH Conditions

Modeling the Growth and Death of Staphylococcus aureus against Melaleuca armillaris Essential Oil at Different pH Conditions

In vitro synergistic interaction between Melaleuca armillaris essential oil and erythromycin against Staphylococcus aureus isolated from dairy cows

Erythromycin and <em>Melaleuca armillaris</em> Essential Oil Combination against <em>Staphylococcus aureus</em> Isolated from Dairy Cows

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