Pizotifen in the Prophylaxis of Cyclical Vomiting

Salmon, M; Walters, DesmondD.

doi:10.1016/s0140-6736(85)91630-7

Cited by 19 publications

(8 citation statements)

References 1 publication

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“…Propranolol, pizotifen and barbiturates, which have been used as prophylactic therapy in CVS, have shown variable success. [13,15–17] The four children given propranolol and two given pizotifen in this series did not show any reduction in the number of attacks at all.…”

Section: Discussionmentioning

confidence: 60%

Cyclic vomiting syndrome in South‐East Asian children

Lee

Kaur

Boey

et al. 1998

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 60%

Cyclic vomiting syndrome in South‐East Asian children

Lee

Kaur

Boey

et al. 1998

J Paediatrics Child Health

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“…Prevention of attacks by use of medication is based on similarities of CVS with migraine and involves the use of pizotifen, cyproheptidine or a beta-blocker. Case reports have documented the success of these agents in some instances (27,28). Our earlier reports, however, highlighted the difficulties in achieving prophylaxis in those individuals who have more severe or frequent symptoms (29).…”

Section: Discussionmentioning

confidence: 87%

Precipitants and aetiology of cyclic vomiting syndrome

Withers¹,

Silburn²,

Forbes³

1998

SPAE

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Thirty-two patients aged 2-22 y with cyclic vomiting syndrome (CVS), and 64 age- and gender-matched controls were assessed to determine the nature, severity, precipitants and associated features of attacks and the incidence of potential aetiological factors. The mean age of onset was 3.5 y. Patients experienced a mean of nine attacks per year, of average duration 2.4 d, and two-thirds missed more than 10 d of school per year. Patients were more likely to have migraine and co-ordination difficulties, a past history of forceps delivery and gastroesophageal reflux than controls. Compared with controls, subjects had a higher incidence of psychological symptoms (38% compared with 19%) and migraine (37% compared with 9%). CVS is a chronic, disabling condition and is a migraine variant, with attacks usually precipitated by stress and intercurrent infections.

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“…10,11,13 5HT has long been implicated in the pathophysiology of migraine, and blockade of 5HT2 receptors has been shown to act prophylactically in abdominal migraine. 14,15,16 The diagnosis of abdominal migraine is made on history and normal physical examination. 1,6,17,18,19 However, diagnostic criteria for abdominal migraine have not been defined, 19,20 and Hockaday 21 has stated that; "the need for diagnostic caution cannot be over emphasized".…”

Section: Introductionmentioning

confidence: 99%

The VER as a Diagnostic Marker for Childhood Abdominal Migraine

Mortimer

Good

1990

Headache

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Abdominal migraine is a common childhood migraine equivalent, for which diagnostic criteria have not been defined. As in other children with migraine equivalents this leads to difficulties in diagnosis and determination of prevalence. By recording the fast wave activity (beta rhythmn) in the visual evoked response (VER) to red and white flash, the pattern stimulation, 27 out of 28 children with clinically diagnosed abdominal migraine revealed significant differences compared with normal controls, outside the attack phase. Comparisons with children diagnosed as migraine with or without aura revealed, from the VER findings of higher amplitude fast wave activity and the presence of paroxysmal sharp wave activity, that abdominal migraine appears to be a specific form of childhood migraine. We found that both clinically and electrophysiologically, abdominal migraine changes with age; older children exhibiting a shorter duration of abdominal pain during attacks, and less evidence of sharp wave activity in the VER.

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Pizotifen in the Prophylaxis of Cyclical Vomiting

Cited by 19 publications

References 1 publication

Cyclic vomiting syndrome in South‐East Asian children

Cyclic vomiting syndrome in South‐East Asian children

Precipitants and aetiology of cyclic vomiting syndrome

The VER as a Diagnostic Marker for Childhood Abdominal Migraine

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