PIXSIC, a Pixelated β+-Sensitive Probe for Radiopharmacological Investigations in Rat Brain: Binding Studies with [18F]MPPF

Balasse, Laure; Maerk, Julia; Pain, Frédéric; Genoux, Aurélie; Fieux, Sylvain; Morel, C.; Gisquet-Verrier, Pascale; Zimmer, Luc; Lanièce, P.

doi:10.1007/s11307-014-0785-5

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…The width of 610 µm was chosen close to PIXSIC dimensions. PIXSIC probe, with a 200 × 690 µm 2 section, produced consistent results compared to microPET in pharmacological studies without uptake modification attributable to tissue damages [28]. Consequently, we are confident that the implantation will not be a major limitation for the measurements.…”

Section: Discussionmentioning

confidence: 63%

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MAPSSIC, a Novel CMOS Intracerebral Positrons Probe for Deep Brain Imaging in Awake and Freely Moving Rats: A Monte Carlo Study

Ammour

Heymes

Bautista

et al. 2019

IEEE Trans. Radiat. Plasma Med. Sci.

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires

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Section: Discussionmentioning

confidence: 63%

“…The in vivo measurements and quantification procedure should follow the well validated one developed for PIXSIC described in [11,28]. In particular two probes are usually inserted, one in the region of interest and one in a reference tissue (for example the cerebellum for 18 F-MPPF or 11 Craclopride studies).…”

Section: Discussionmentioning

confidence: 99%

MAPSSIC, a Novel CMOS Intracerebral Positrons Probe for Deep Brain Imaging in Awake and Freely Moving Rats: A Monte Carlo Study

Ammour

Heymes

Bautista

et al. 2019

IEEE Trans. Radiat. Plasma Med. Sci.

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“…Good correlations have been reported between in vivo beta-microprobe measurements and ex vivo brain homogenate and in vivo microPET measurements of respectively D 2 and 5HT 1A target occupancy in rat brain. [56,57] The potential advantages of beta-microprobe are that the target occupancy could be measured in awake, non-anesthetized animals and simultaneous assessment of drug-induced changes in behavior is allowed, which are critical for drugs that act on CNS receptors. Nevertheless, the surgical implantation procedures might interfere with the neurochemistry and the pharmacokinetics and pharmacodynamics of the drug and tracer.…”

Section: Beta-microprobementioning

confidence: 99%

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients

Witte

Wong

Nederpelt

et al. 2015

Expert Opinion on Drug Discovery

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More scientific evidence is required for the rational selection and development of drug-candidates on the basis of in vitro estimates of drug-target binding kinetics. To elucidate the value of in vitro binding kinetics measurements, it is necessary to obtain information on system-specific properties which influence the kinetics of target occupancy and drug effect. Mathematical integration of this information enables the identification of drug-specific properties which lead to optimal target occupancy and drug effect in patients.

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Implantable CMOS pixel sensor for positron imaging in rat brain

Heymes

Ammour

Bautista

et al. 2018

Nuclear Instruments and Methods in Physics Research Section A:

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IMIC is a Monolithic Active Pixel Sensor prototype designed for the MAPSSIC project, which aims at developing wireless intracerebral probes dedicated to image positron-emitting source activity in the brain of awake and freely moving rats. Former experiments with the PIXSIC positron probe based on a passive sensor have validated the proof of concept, but have also shown limitations with regards to the probe robustness and to its transparency to annihilation photons. The IMIC circuit features a matrix of 16 × 128 active pixels of 30 × 50 µm 2 size and targets to overcome the PIXSIC probe drawbacks by exploiting a thin sensitive layer of 18 µm, still featuring an overall thickness close to 300 µm. Additionally, by using a low power (55 nW/pixel) in-pixel front-end architecture providing binary output, IMIC solves the challenge of implanting an active sensor in tissues where overheating is forbidden. The needle-shaped sensor 610 µm × 12000 µm was fabricated and tested in laboratory. The whole sensor dissipates 160 µW and its imaging capabilities were asserted with various sources : 55 Fe, 90 Sr and 18 F. These tests also demonstrated robust count-rate measurement with IMIC in the range 10-1000 counts/matrix/s. Finally, a dedicated setup qualitatively confirmed excellent insensitivity to 511 keV γ-rays. In this paper, we present the sensor requirements and its detailed design. We also discuss the first characterisation results and the outlook for the integration of IMIC into an implantable probe.

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PIXSIC, a Pixelated β+-Sensitive Probe for Radiopharmacological Investigations in Rat Brain: Binding Studies with [18F]MPPF

Abstract: These results demonstrate the ability of the PIXSIC device to record reliably the binding of PET ligands, with a high spatiotemporal resolution in anesthetized rodents. These first in vivo results are a key stage on the path to its implementation in awake freely moving animals.

Cited by 4 publications

References 10 publications

MAPSSIC, a Novel CMOS Intracerebral Positrons Probe for Deep Brain Imaging in Awake and Freely Moving Rats: A Monte Carlo Study

MAPSSIC, a Novel CMOS Intracerebral Positrons Probe for Deep Brain Imaging in Awake and Freely Moving Rats: A Monte Carlo Study

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients

Implantable CMOS pixel sensor for positron imaging in rat brain

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