PIXE analysis of some Nigerian anti-diabetic medicinal plants (II)

Olabanji, S.O.; Adebajo, AC; Omobuwajo, O.R.; Ceccato, D.; Buoso, M.C.; Moschini, G.

doi:10.1016/j.nimb.2013.06.052

Cited by 15 publications

(10 citation statements)

References 8 publications

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“…M. longistyla has been reportedly used for managing different ailments in traditional medicine [13,14,15,16,17,18]. In an ethnomedical survey carried out by us, the plant was mentioned as a memory enhancer.…”

Section: Resultsmentioning

confidence: 99%

“…It has long, arching stems that are about 4 m long [12]. M. longistyla has been used traditionally as an antihemorrhagic in Benin [13], as an antidiabetic in Nigeria and Côte d’Ivoire [14,15], as a contraceptive and for the restoration of fertility [16], for ulcers [17], and for diarrhea [18]. Fresh wildly-collected leaves are eaten as a vegetable by the Gourmantché, Aïzo, and Cotafon people in Benin [19].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Anticholinesterase Activities of Macrosphyra Longistyla (DC) Hiern Relevant in the Management of Alzheimer’s Disease

2019

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Macrosphyra longistyla has been used in many traditional systems of medicine for its anti-hemorrhagic, antidiabetic, anti-ulcer, and anti-diarrhea properties. The acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitions of the crude methanol extracts and its various partitioned fractions were determined by a modified method of Ellman. An evaluation of the antioxidant activity was carried out using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging, ferric reducing power, and nitric oxide scavenging assays. The total flavonoids were estimated based on the aluminum chloride method, while the total tannins and phenolics were estimated based on the vanillin–HCl and Folin–Ciocalteu method, respectively. The ethyl acetate fraction had the highest DPPH radical scavenging activity, and the highest ferric reducing power with a concentration providing 50% inhibition (IC50) of 0.079 mg/mL and 0.078 mg/mL, respectively, while the crude methanol extract had the highest nitric oxide scavenging activity with an IC50 of 0.008 mg/mL. The methanol extract had the highest phenolics and flavonoids contents, while the aqueous fraction had the highest tannin content. The crude methanol extract had the best AChE and BuChE inhibitory action, with an IC50 of 0.556 µg/mL and 5.541 µg/mL, respectively, suggesting that the plant had a better AChE inhibiting potential. A moderate correlation was observed between the phenolic content and DPPH radical scavenging, NO radical scavenging, and AChE inhibitory activities (r2 = 0.439, 0.430, and 0.439, respectively), while a high correlation was seen between the flavonoid content and these activities (r2 = 0.695, 0.724, and 0.730, respectively), and the ferric reducing antioxidant power correlated highly with the proautocyanidin content (r2 = 0.801). Gas chromatography mass spectrometry (GCMS) revealed decanoic acid methyl ester (24.303%), 11,14-eicosadienoic acid methyl ester (16.788%), linoelaidic acid (10.444%), pentadecanoic acid (9.300%), and 2-methyl-hexadecanal (9.285%). Therefore, we suggest that M. longistyla contain bioactive chemicals, and could be a good alternative for the management of Alzheimer’s and other neurodegenerative diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anticholinesterase Activities of Macrosphyra Longistyla (DC) Hiern Relevant in the Management of Alzheimer’s Disease

2019

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“…Herein, the elements content and presence of phytochemical in these two medicinal plants were carried out by employing proton induced X-ray emission (PIXE) and gas chromatography-mass spectroscopy (GC-MS) techniques and their possible roles as cardio-protective agents is discussed for the first time. Proton induced X-ray emission is one way simultaneous, reliable, sensitive, quantitative multi-elemental and nondestructive suitable for routine analysis due to minimal sample preparation and less turn over time and it was earlier used for this purpose several times [17,21] while GC has a key technological platform for identification of plants phytochemical. The main emphasize of this study is on finding plant based bioactive compounds and elements with focus on the impactful way to translate tradition knowledge of the therapeutic usage of ethnomedicinal plants in the treatment of diseases that could facilitate meaningful scientific data and public health benefits in the context of prevention, delaying and curing of cardiovascular diseases.…”

Section: Elemental and Phytochemicals Profile In Ethno Medicinal Planmentioning

confidence: 99%

Elemental and Phytochemicals Profile in Ethno Medicinal Plants Used for Treating Cardiovascular Diseases by Mizo-Tribe of North Eastern India

2019

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Proton induced X-ray emission (PIXE) and gas chromatography-mass spectroscopy (GC-MS) were used to detect elements as well as phytochemicals in the Centella asiatica and Elsholtzia communis having possible roles for cardio-protections. Elements namely K, Cl, Ca, Fe, Mn, Zn and Cu were present in varying concentration with notable concentration of K, Cl and Fe. Phytochemicals such as stigmasterol, β-sitosterol, phytol and N-hexadeconic acid were detected in the C. asiatica while E. communis was found to contain β-carotene, β-sitosterol, phytol and N-hexadeconic acid. The study reveals that these two ethnomedicinal herbs are found to contain elements and phytochemical known for their cardio-protective roles.

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“…Contudo, Akinboro e Bakare 153 sugerem uma possível atividade mutagênica do extrato aquoso das folhas de O. gratissimum e Hernández et al 154 citam efeitos tóxicos agudos e significativos de hepatotoxicidade e nefrotoxicidade na dose 3 g/kg de extrato fluido das folhas dessa espécie. Apesar de sua comprovada atividade hipoglicêmica [109][110][111][112] , Olabanji et al 155 sugerem, para prevenir complicações, que pacientes diabéticos evitem o uso dessa espécie em razão da presença de arsênio (As), cromo (Cr) e cobre (Cu) nas suas folhas acima da recomendação diária de ingesta.…”

Section: Toxicidade De O Gratissimumunclassified

Ocimum gratissimum l.: uma revisão das atividades farmacológicas da espécie e do seu óleo essencial

Vilanova¹,

Luz²,

Silveira³

et al. 2019

Conexão Ci.

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Introdução: Ocimum gratissimum L. (alfavaca) é uma herbácea pertencente à Relação Nacional de Plantas Medicinais de Interesse ao SUS e muito utilizada na fitoterapia e por comunidades tradicionais brasileiras para tratamento de diversos males. Objetivo: Sistematizar e identificar as principais atividades farmacológicas cientificamente comprovadas e componentes químicos responsáveis pela propriedades biológicas. Materiais e métodos: Foi realizada uma revisão bibliográfica em bases de dados de periódicos e compiladas as informações sobre as propriedades farmacológicas, parte da planta utilizada, modo de uso e meios de extração dos metabólitos secundários dessa espécie. Resultados: O óleo essencial das folhas dessa espécie é o mais empregado nos estudos farmacológicos, destacando-se suas ações antimicrobianas (de amplo espectro contra bactérias Gram positivas e negativas e fungos). Esse vegetal de modo geral tem intensa atividade antioxidante, a qual inclusive é considerada a responsável por outras propriedades biológicas atribuídas a alfavaca. Conclusões: Apesar de suas várias propriedades farmacológicas cientificamente comprovadas, o uso prolongado dessa planta deve ser evitado ou monitorado pelos riscos de toxicidade. Palavras-chave: Atividade biológica; Planta medicinal; Compostos aromáticos.

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PIXE analysis of some Nigerian anti-diabetic medicinal plants (II)

Cited by 15 publications

References 8 publications

Antioxidant and Anticholinesterase Activities of Macrosphyra Longistyla (DC) Hiern Relevant in the Management of Alzheimer’s Disease

Antioxidant and Anticholinesterase Activities of Macrosphyra Longistyla (DC) Hiern Relevant in the Management of Alzheimer’s Disease

Elemental and Phytochemicals Profile in Ethno Medicinal Plants Used for Treating Cardiovascular Diseases by Mizo-Tribe of North Eastern India

Ocimum gratissimum l.: uma revisão das atividades farmacológicas da espécie e do seu óleo essencial

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