PIXE Analysis in Different Stages of Psoriatic Skin

Kurz, Kathinka D.; Steigleder, G. K.; Bischof, W.; Gonsior, B.

doi:10.1111/1523-1747.ep12525385

Cited by 17 publications

(14 citation statements)

References 11 publications

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“…The presence of phosphorus in the environment would then result in aggravation of psoriatic lesions. Psoriatic changes also involve increased potassium levels possibly related to modified reaction of cells to steroid hormones [23]. The topical administration of steroids decreases the intensity of skin changes.…”

Section: Discussionmentioning

confidence: 99%

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

Tubek

2008

Biol Trace Elem Res

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The content of chemical elements in rainwater is a suitable indirect indicator of its presence in airborne dust, sometimes referred to as rain fallout. Rainwater is considered a suitable monitor for environmental or natural pollution. The yearly content of chemical elements in rainwater may be considered as a good indicator for determining the influence of these environmental factors on the human body. We decided to investigate the relationship between chemical elements in rainwater and the frequency of hospitalizations for arterial hypertension, chronic obstructive pulmonary disease, and psoriasis. There is a mild correlation between zinc and cadmium and cases of arterial hypertension. For obstructive pulmonary disease, there is a strong correlation with the content of potassium, calcium, iron, manganese, lead and nickel, and with chloride, sulfide, total nitrogen, and nitrites. There is also a mild correlation with magnesium, zinc, copper, cadmium and chromium, and with ammonium nitrogen. In cases of hospitalization for psoriasis, a correlation was revealed with such elements as potassium, ammonium nitrogen, and phosphorus.

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Section: Discussionmentioning

confidence: 99%

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

Tubek

2008

Biol Trace Elem Res

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“…Several groups have reported increased amount of iron in epidermis of psoriatic plaques compared to uninvolved epidermis or normal epidermis [48,49]. In contrast, another group found much less iron in psoriatic plaques than in normal skin [50]. Any conclusions drawn from those studies regarding total-body iron homeostasis must be tempered by the fact that neither were there measurements of iron stores in other tissues (particularly bone marrow) nor was there consideration of the possibility that increased losses through desquamation might be compensated by increased absorption.…”

Section: Role Of Desquamation In Nutritional Homeostasismentioning

confidence: 99%

Epidermal desquamation

Milstone¹

2004

Journal of Dermatological Science

125

103

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Epidermal desquamation, a continuous but insensible bodily activity, is largely ignored unless the rate or amount of scale production becomes abnormal. It is the last topic to be considered in any serious discussion of epidermal growth and differentiation, but is becoming an increasingly fertile ground for investigation. This review summarizes: (a) methods for measuring desquamation; (b) variables that affect normal desquamation; (c) mechanisms of desquamation; (d) the role of desquamation in nutritional homeostasis; and (e) the role of desquamation as a first line of defense. Consideration is given to whether desquamation might be harnessed to eliminate or remediate toxins that have accumulated in the body.

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“…However, the iron-deficit state could be a secondary condition or trigger a wide range of mucocutaneous alterations, such as erythroderma, exfoliative dermatitis, psoriasis, eczema, and many others [21]. Many authors have observed significantly low serum iron levels in psoriatic patients [22][23][24][25]. Recently, oxidative stress has been implicated in the etiopathology of psoriasis.…”

Section: Discussionmentioning

confidence: 99%

The Effects of FeCl3 and Fe–EDTA on the Development of Psoriasis

Shi

Yang

Chen

2010

Biol Trace Elem Res

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The effects of FeCl₃ and Fe-EDTA on the development of psoriasis were studied in the mouse model of vaginal epithelium and tail epidermis. The mitoses of vaginal epithelial cell in female mice of their estrogenic stage and the formation of granular cell layers in male mouse tail scale were observed. Mice were randomly divided into eight groups and treated with normal saline, methotrexate, and different doses of two iron forms, FeCl₃ and Fe-EDTA, respectively, for 10 days. To explore the influence of FeCl₃ and Fe-EDTA on the excretion of Cu, Fe, Zn, Ca, Mg, Mn, and Se, the concentration of those elements in liver and kidney was analyzed by atomic absorption spectrometry. The different doses of FeCl₃ or Fe-EDTA could obviously inhibit the mitoses of vaginal epithelial cell (p< 0.05) and promote the formation of granular cell layers in mice tail scale (p < 0.05). No statistically significant results were found between the groups of FeCl₃ and Fe-EDTA, and between experimental groups and methotrexate group acted as the positive control (p>0.05). Compared with the negative group, the concentrations of Cu, Fe, Zn, Ca, Mg, Mn, and Se in liver and kidney of experimental groups and positive control group were not significantly changed (p > 0.05). FeCl₃ and Fe-EDTA are as effective as methotrexate on inhibiting hyperplasia of epidermal cells and increasing the formation of granular cell layers, and the concentrations of Cu, Fe, Zn, Ca, Mg, Mn, and Se in liver and kidney of experimental groups and positive control group were not significantly changed compared with the negative group, possibly retarding the development of psoriasis.

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PIXE Analysis in Different Stages of Psoriatic Skin

Cited by 17 publications

References 11 publications

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

The Content of Elements in Rainwater and its Relation to the Frequency of Hospitalization for Arterial Hypertension, Chronic Obstructive Pulmonary Disease, and Psoriasis in Opole Voivodship, Poland During 2000–2002

Epidermal desquamation

The Effects of FeCl3 and Fe–EDTA on the Development of Psoriasis

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